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| 1 | Optimal dual antiplatelet therapy strategy in elderly patients with acute coronary syndrome显示文摘One out of three hospitalizations for acute coronary syndrome(ACS)involve nowadays elderly patients,carrying together a significant burden of comorbidities and a higher risk of complications.In particular,both ischemic and haemorrhagic risk are markedly enhanced in advanced age,and strictly interconnected,challenging the management of dual antiplatelet therapy(DAPT)in these patients.The recent development of several therapeutic options in terms of duration and combination of antiplatelet agents have offered a wider spectrum of opportunities for a more individualized approach in the management of DAPT after an ACS,although the criteria for the selection of the most appropriate strategy in each patient still lack validation.In particular,dose-adjustment,early aspirin discontinuation,laboratory-driven tailoring and shorter or extended DAPT have been addressed with promising safety and efficacy results.The present review provides an updated overview on the emerging evidencefrom randomized clinical trials and subanalyses dedicated to the management of DAPT in elderly patients presenting with ACS. | Monica Verdoia Rocco Gioscia Giuseppe De Luca | 2021 | Journal of Geriatric Cardiology2021，18，3： | 4 |
| 2 | Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice显示文摘 | Rachel A. Gioscia‐Ryan Thomas J. LaRocca Amy L. Sindler Melanie C. Zigler Michael P. Murphy Douglas R. Seals | 2014 | J Physiol2014，，12： | 1 |
| 3 | PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction显示文摘 | EDWARS A G REES M L GIOSCIA R A | | 0，，23： | 1 |
| 4 | PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction显示文摘 | Edwards AG Rees ML Gioscia RA | 2009 | J Physiol2009，587，23： | 1 |
| 5 | Optimization of the pharmacological therapy in patients with polyvascular disease: A multidisciplinary approach显示文摘The recent shift of the concept of cardiovascular disease as a chronic progressive condition,potentially involving multiple districts,has driven attention to the optimal management of patients with concomitant coronary and peripheral artery disease,representing a subset of patients with an increased risk of events and impaired survival.Recent pharmacological achievements in terms of antithrombotic therapy and lipid-lowering drugs allow multiple therapeutical combinations,thus requiring optimizing the treatment in a tailored fashion according to patients’risk profiles.Nevertheless,data dedicated to this specific subset of patients are still modest.We summarize currently available strategies and indications for the management of antithrombotic and lipid-lowering drugs in patients with the poly-vascular disease. | Rocco Gioscia Claudio Castagno Monica Verdoia Barbara Conti Enzo Forliti Andrea Rognoni | 2023 | World Journal of Cardiology2023，15，4： | 0 |
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