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| 1 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 2 | Automorphisms of certain unipotent groups显示文摘 | Gibbs J A | 1970 | J Algebra1970，14，： | 3 |
| 3 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 4 | Generation of cDNA probes directed by amino acid sequence: Cloning of urate oxidase 显示文摘 | Lee C C Wu X Gibbs R A | 1988 | Science1988，239，： | 2 |
| 5 | Long-term aeration management for improved N-removal via SND in a sequencing batch reactor显示文摘 | THIRD K A GIBBS B NEWLAND M | 2005 | Water Research2005，39，： | 1 |
| 6 | A tobamovirus of a green alga显示文摘 | Gibbs A Skotnicki A H Gardinek J | 1975 | Virology1975，64，2： | 1 |
| 7 | Structural evolution of extensional basin margins 显示文摘 | Gibbs A D | 1984 | Journal of Geological Society of London1984，141，4： | 1 |
| 8 | From where did the 2009 ~swine-origin~ influenza A vi- rus(H1N1)emerge?显示文摘 | Gibbs A J Armstrong JS Downie JC | 2009 | Virol J2009，6，： | 1 |
| 9 | Blockade of methamphet- amine-induced depression of tyrosine hydroxylase by GA- BA transaminase inhibitors显示文摘 | HOTEHKISS A GIBB J W | 1980 | Eur J Pharmaeol1980，66，2： | 1 |
| 10 | Using team-based learning to prepare medical students for future problem-based learning显示文摘 | Abdelkhalek N Hussein A Gibbs T | 2010 | Med Teach2010，32，2： | 1 |
| 11 | Contributing factorsin construction accidents 显示文摘 | HASLAM R A HIDE S A GIBB A G F | 2005 | Applied Ergonomics2005，36，40： | 1 |
| 12 | Re-engineering through pre-assembly: Client expectations and drivers 显示文摘 | GIBB A ISACK F | 2003 | Building Research & Information2003，31，2： | 1 |
| 13 | Deletion screening of the duchenne muscular dystrophy locus via multiplex DNA amplification 显示文摘 | CHAMBERLAIN J S GIBBS R A RANIER J E | 1988 | Nucleic Acids Res1988，16，23： | 1 |
| 14 | Insights into social insects from the genome of the honeybee Apis mellifera 显示文摘 | WEINSTOCK G M ROBINSON G E GIBBS R A | 2006 | Nature2006，443，： | 1 |
| 15 | Peripheral enhanced and spatial contrast uptake heterogeneity of primary breast tumors: quantitative assessment wit b dynamic MRI 显示文摘 | Mussurakis S Gibbs P Horsman A | 1998 | J Comput Assist Tomogr1998，22，： | 1 |
| 16 | The crystal structure of synthetic titanite CaTiOSiO4 and the domain textures of natural titanites显示文摘 | Speer J A Gibbs G V | 1976 | American Mineralogist1976，61，： | 1 |
| 17 | Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction - and phesphatidylinesitol-3-kinase-independent pathway 显示文摘 | Etgen G J Jr Fryburg D A Gibbs E M | 1997 | Diabetes1997，46，： | 1 |
| 18 | Structural interactions between Kisspeptin and GnRH neurons in the me- diobasal hypothalamus of the male rhesus monkey (Maeaca mulatta) as revealed by double immunofluoreseenee and eonfo-al microscopy 显示文摘 | Ramaswamy S Guerriero K A Gibbs R B | 2008 | Endocrinology2008，149，9： | 1 |
| 19 | Production and characterization of bioactive peptides from soyhydrolysate and soy-fermented food显示文摘 | Gibbs BF Zougman A Masse R | 2004 | Food Research International2004，37，2： | 1 |
| 20 | Calcium-based sorbents for simultaneous NOx/SOx reduction in a down-fired furnace显示文摘 | Patsias A A Nimmo W Gibbs B M | 2005 | Fuel2005，84，1415： | 1 |
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