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| 1 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 2 | 人体子宫内膜血管内皮生长因子的研究显示文摘目的 :对人体子宫内膜增殖期 (n =3)、分泌期 (n =6 )和增生过长 (n =6 )标本 ,进行VEGF的免疫定位和半定量测定 ,了解雌激素对子宫内膜VEGF的影响。方法 :研究组用免疫组织化学方法 ,对照组用无关的免疫球蛋白代替第一及第二抗体 ,用辅助视频图像分析系统进行计算。结果 :增殖期VEGF在腺体 (P <0 .0 0 1)和间质 (P <0 .0 1)的浓度 ,明显高于分泌期和子宫内膜增生过长 ,总的看来 ,腺体的VEGF高于间质。结论 :雌激素提高子宫内膜的VEGF的含量 ,并与增殖晚期新的血管形成和血管通透性增加有关。此外 ,子宫内膜增生过长的腺体VEGF并不升高 ,提示人体子宫内膜的腺体生长和血管生成调节是不同的。 | 胡珈瑞 陈兴会 Ghosh D | 2001 | 武汉大学学报(医学版)2001，22，2： | 3 |
| 3 | Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis:are the effects molecular weight dependent显示文摘 | Ghosh P Guidolin D | | Seminars in Arthritis and Rheumatism0，，： | 2 |
| 4 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 5 | Adsorption of methylene blue on kaolinite显示文摘 | GHOSH D BHATTACHARYYA K G | 2002 | Appl Clay Sci2002，20，： | 2 |
| 6 | Delineation of prognostic biomarkers in prostate cancer显示文摘 | Dhanasekaran SM Barrrette TR Ghosh D | | 0，，： | 2 |
| 7 | European evidence-based Consensus on the management of ulcerative colitis: Current management显示文摘 | S.P.L. Travis E.F. Stange M. Lémann T. ?resland W.A. Bemelman Y. Chowers J.F. Colombel G. D'Haens S. Ghosh P. Marteau W. Kruis N.J.McC. Mortensen F. Penninckx M. Gassull | 2008 | Journal of Crohn’s and Colitis2008，，1： | 2 |
| 8 | Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats显示文摘 | R Maiti D Jana U.K Das D Ghosh | 2004 | Journal of Ethnopharmacology2004，，1： | 2 |
| 9 | Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function显示文摘 | Ghosh D Konishi T | 2007 | Asia Pac J Clin Nutr2007，16，2： | 1 |
| 10 | TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha 显示文摘 | Ghosh T K Mickelson D J Solberg J C | 2007 | Immunopharmacol2007，7，： | 1 |
| 11 | Characteristics of humic substances in cultivated and natural forest soils of Sikkim显示文摘 | Martin D Srivastava P C Ghosh D | 1998 | Geoderma1998，84，： | 1 |
| 12 | Stimulation of activated sludge cultures for enhanced heavy metal removal显示文摘 | Chang D Fukushi K Ghosh S | 1995 | Water Environment Research1995，67，5： | 1 |
| 13 | Approximation methods in multidisciplinary analysis and optimization: a panel discussion 显示文摘 | Simpson T W Booker A J Ghosh D | 2004 | Structural and Multidisciplinary Optimization2004，27，5： | 1 |
| 14 | Comparative study of precipitation behavior and texture formation in continu- ously annealed Ti and Ti + Nb added interstitial -free high -strength steels 显示文摘 | Ghosh P Ray R K Ghosh C and Bhattacharjee D | 2008 | Scripta Materialia2008，58，： | 1 |
| 15 | Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin 显示文摘 | Salzman NH Ghosh D Huttner KM | 2003 | Nature2003，，422： | 1 |
| 16 | Optimum stacking pattern for multi-stream plate-fin heat exchanger through a genetic algorithm显示文摘 | Ghosh S Ghosh I Pratihar D K | 2011 | International Journal of Thermal Sci- ence2011，50，2： | 1 |
| 17 | Auditor Tenure and Perceptions of Audit Quality 显示文摘 | Ghosh A Moon D | 2005 | The Accounting Review2005，80，02： | 1 |
| 18 | A comparative study of oral tramadol andibuprofen in postoperative pain in operations of lower abdomen显示文摘 | Banerjee M Bhaumik D J Ghosh A K | 2011 | J Indian MedAssoc2011，109，62： | 1 |
| 19 | Whole-genome characterization of human group C rotaviruses:Identification of two lineages in the VP3 gene显示文摘 | Yamamoto D Ghosh S Kuzuya M | 2011 | J Gen Virol2011，92，： | 1 |
| 20 | Approximationmethods in multidisciplinary7 analysis and optimization: a panel discussion显示文摘 | SIMPSON T W BOOKER A J GHOSH D | 2004 | Structural and Multidisciplinaiy Optimization2004，27，5： | 1 |
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