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| 1 | Antibacterial activities of some plant extracts alone and in combination with different antimicrobials against multidrug-resistant Pseudomonas aeruginosa strains显示文摘Objective:To evaluate the possible in vitro interaction between ethanolic extracts of Rhus coriaria[R.coriaria)(seed),Sacropoterium spinosum(S.spinosum)(seed),Rosa damascena(R. damascene)(flower) and certain known antimicrobial drugs including oxytetracycline HCl, penicillin C,cephalexin,sulfadimethoxine as sodium,and enr of loxacin.This synergy study was carried out against 3 clinical strains of multidrug-resistant Pseudomonas aeruginosa (P.aeruginosa).Methods:Evaluation of synergy interaction between plant extracts and antimicrobial agents was carried out using microdilution method.Results:The results of this study showed that there is a decrease in the MIC in case of combination of ethanolic plant extracts and test antimicrobial agents.The most interesting result was that the combination between R. coriaria and these antibiotics,showed a high decrease in minimum inhibitory concentration(MIC), and a strong bactericidal activity against these strains.Conclusions:These results may indicate that combinations between R.coriaria extract and these antibiotics could be useful in fighting emerging drug-resistance P.aeruginosa,which may due to that R.coriaria extract contain natural inhibitors working by different mechanisms or inhibiting efflux pumps.Now we have experiments underway leading to the identification of the active molecules present in R.coriaria.Further,in vivo experiments are needed to confirm pseudomonal protection. | Ghaleb Adwan Bassam Abu-Shanab Kamel Adwan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 4 |
| 2 | Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans显示文摘Objective:To evaluate the antimicrobial activity of ethanolic extract of Ecballium elaterium(E. elaterium)fruits alone against Staphylococcus aureus(S.aureus) strains and Candida albicans(C.albicans)strains,or in combination with penicillin against Staphylococcus areus strains. Methods:Evaluation of the antimicrobial activity or synergy interaction was carried out using microdilution method.Results:The results showed that ethanolic extract of E.elaterium fruits has antimicrobial activity against methicillin resistant S.aureus(MRSA),methicillin sensitive S. aureus(MSSA) and C.albicans.This extract showed a significant decrease in minimum inhibitory concentrations(MIC)of penicillin against both MRSA and MSSA strains.Fractional inhibitory concentration index(FIC)between penicillin and ethanolic extract of E.elaterium fruits against these test strains was less than 0.5.Conclusions:This study suggests that ethanolic extract of E.elaterium fruits has antimicrobial activity against S.aureus and C.albicans and there is a possibility of concurrent use of penicillin and E.elaterium extract in combination in the treatment of infections caused by MRSA and MSSA strains.A wider study is needed to identify the effective components,the mode of action and the possible toxic effect in vivo of these ingredients. | Ghaleb Adwan Yousef Salameh Kamel Adwan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 3 |
| 3 | Assessment of antifungal activity of herbal and conventional toothpastes against clinical isolates of Candida albicans显示文摘Objective:To detect the anticandidal activity of nine toothpastes containing sodium fluoride, sodium monofluorophosphate and herbal extracts as an active ingredients against 45 oral and non oral Candida albicans(C.albicans) isolates.Methods:The antifungal activity of these toothpaste formulations was determined using a standard agar well diffusion method.Statistical analysis was performed using a statistical package,SPSS windows version 15,by applying mean values using one-way ANOVA with post-hoc least square differences(LSD) method.A P value of less than 0.05 was considered significant.Results:All toothpastes studied in our experiments were effective in inhibiting the growth of all C.albicans isolates.The highest anticandidal activity was obtained from toothpaste that containing both herbal extracts and sodium fluoride as active ingredients, while the lowest activity was obtained from toothpaste containing sodium monofluorophosphate as an active ingredient.Antifungal activity of Parodontax toothpaste showed a significant difference(P<0.001) against C.albicans isolates compared to toothpastes containing sodium fluoride or herbal products.Conclusions:In the present study,it has been demonstrated that toothpaste containing both herbal extracts and sodium fluoride as active ingredients are more effective in control of C.albicans,while toothpaste that containing monofluorophosphate as an active ingredient is less effective against C.albicans.Some herbal toothpaste formulations studied in our experiments,appear to be equally effective as the fluoride dental formulations and it can be used as an alternative to conventional formulations for individuals who have an interest in naturally-based products.Our results may provide invaluable information for dental professionals. | Ghaleb Adwan Yousef Salameh Kamel Adwan Ali Barakat | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 3 |
| 4 | Synergistic effects of plant extracts and antibiotics on Staphylococcus aureus strains isolated from clinical specimens显示文摘Objective:This study has been done to evaluate the interaction between water extracts of Psidium guajava, Rosmarinus officinalis,Salvia fruticosa,Majorana syriaca,Ocimum basilucum,Syzygium aromaticum,Laurus nobilis,and Rosa damascena alone and then synergy testing of these extracts with known antimicrobial agents including oxytetracycline HCl,gentamicin sulfate,penicillin G,cephalexin and enrofloxacin.This study was conducted against five S.aureus isolates;one is Methicillin -resistant Staphylococcus aureus(MRSA) and 4 Methicillin - sensitive Staphylococcus aureus(MSSA).Methods:Evaluation of the interaction between plant extracts and different antimicrobial agents has been done using well - diffusion and microdilution methods. Results:The results of the conducted experiments using well - diffusion method demonstrate that these plants showed in vitro interactions between antimicrobial agents and plant extracts were additive,while using microdilution method showed synergistic effects with significant reduction in the MICs of the test antibiotics against these strains of S.aureus.This change in MIC was noticed in all plant extracts against test antibiotics including these plants showed weak antibacterial activity by well diffusion method.Synergism effect was occurred in both sensitive and resistant strains but the magnitude of minimum fold reduction of inhibitory concentration in resistant strains especially MRSA strain was higher than the sensitive strains.Coclusion:This study probably suggests the possibility of concurrent use of these antimicrobial drugs and plant extracts in combination in treating infections caused by S.aureus strains or at least the concomitant administration may not impair the antimicrobial activity of these antibiotics. | Ghaleb Adwan Mohammad Mhanna | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，3： | 3 |
| 5 | The diverse functions of Krtippel-like factors g and 5 in epithelial biology and pathobiology 显示文摘 | McConnell BB Ghaleb AM Nandan MO | 2007 | Bioessays2007，29，6： | 1 |
| 6 | Haploinsufficiency of Kruppel like factor 4 promotes adenomatous polyposis coil dependent intestinal tumorigenesis 显示文摘 | Ghaleb AM McConnell BB Nandan MO | 2007 | Cancer Res2007，67，15： | 1 |
| 7 | Recent sedimentary history of anthropogenic impacts on the Culiacan River Estuary, northwestern Mexico: geochemical evidence from organic matter and nutrients显示文摘 | A.C Ruiz-Fernández C Hillaire-Marcel B Ghaleb M Soto-Jiménez F Páez-Osuna | 2002 | Environmental Pollution2002，，3： | 1 |
| 8 | Haploinsufficiencyof Kruppel-like factor 4 promotes adenomatous polyposis coli de-pendent intestinal tumorigenesis显示文摘 | Ghaleb AM Mcconnell BB Nandan MO | 2007 | Cancer Res2007，67，15： | 1 |
| 9 | Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene显示文摘 | Amr M. Ghaleb Beth B. McConnell Klaus H. Kaestner Vincent W. Yang | 2010 | Developmental Biology2010，，2： | 1 |
| 10 | Transcriptional profiling of the cell cycle checkpoint gene kruppel - like factor 4 reveals a global inhibitory function in macromolecular biosynthesis 显示文摘 | Whitney EM Ghaleb AM Chen X | 2006 | Gene Expr2006，13，： | 1 |
| 11 | p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells 显示文摘 | Aneja R Ghaleb AM Zhou J | 2007 | Cancer Res2007，67，： | 1 |
| 12 | Notch inhibitsexpression of the Kruppel-like factor 4 tumor suppressor in the in-testinal epithelium显示文摘 | Ghaleb AM Aggarwal G Bialkowska AB | 2008 | Mol Cancer Res2008，6，12： | 1 |
| 13 | Critical appraisal of tocilizumab in the treatment of moderate to severe rheumatoid arthritis显示文摘 | Linda L Hushaw Ray Sawaqed Ghaleb Sweis | 2010 | Ther Clin Risk Manag2010，6，： | 1 |
| 14 | Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake 显示文摘 | Alexandre Marin Hao Sun Ghaleb A Husseini | 2002 | J Controlled Release2002，84，2： | 1 |
| 15 | Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles显示文摘 | Ghaleb A Husseini Natalya Y Rapoport Douglas A Christensen | 2002 | J Colloid Interface Sci2002，24，4： | 1 |
| 16 | Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer显示文摘 | Patel NV Ghaleb AM Nandan MO | 2010 | Cancer Epidemiol Biomarkers Prev2010，19，10： | 1 |
| 17 | Measure- ment and analysis of ambiguity functions of off-air signals for passive coherent location显示文摘 | Griffiths H D Baker C J Ghaleb H | 2003 | Electronics Letters2003，39，13： | 1 |
| 18 | Translocation of soil organic matter following reservoir impoundment in boreal systems: Implications for in situ productivity 显示文摘 | Houel S Louchouarn P Lucotte M Canuel R Ghaleb B | 2006 | Limnol Oceanogr2006，51，3： | 1 |
| 19 | U-Series Dating by the TIMS Technique of Land Snarls from Paleosols in the Canary Islands显示文摘 | GHALEB B | 1995 | Qua ternary Research1995，44，： | 1 |
| 20 | Recent sedimentary history of anthropogenic impacts on the Culiacan River Estuary, northwestern Mexico: geochemical evidence from organic matter and nutrients显示文摘 | RUIZ- FERNA' NDEZ A C HILLARIRE-MARCEL C GHALEB B | 2002 | Environ Pollu2002，118，： | 1 |
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