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| 1 | Targeting the tumor stroma in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common and deadly cancers worldwide. In ninety percent of the cases it develops as a result of chronic liver damage and it is thus a typical inflammationrelated cancer characterized by the close relation between the tumor microenvironment and tumor cells. The stromal environment consists out of several cell types, including hepatic stellate cells, macrophages and endothelial cells. They are not just active bystanders in the pathogenesis of HCC, but play an important and active role in tumor initiation, progression and metastasis. Furthermore, the tumor itself influences these cells to create a background that is beneficial for sustaining tumor growth. One of the key players is the hepatic stellate cell, which is activated during liver damage and differentiates towards a myofibroblast-like cell. Activated stellate cells are responsible for the deposition of extracellular matrix, increase the production of angiogenic factors and stimulate the recruitment of macrophages. The increase of angiogenic factors(which are secreted by macrophages, tumor cells and activated stellate cells) will induce the formation of new blood vessels, thereby supplying the tumor with more oxygen and nutrients, thus supporting tumor growth and offering a passageway in the circulatory system. In addition, the secretion of chemokines by the tumor cells leads to the recruitment of tumor associated macrophages. These tumor associated macrophages are key actors of cancer-related inflammation, being the main type of inflammatory cells infiltrating the tumor environment and exerting a tumor promoting effect by secreting growth factors, stimulating angiogenesis and influ-encing the activation of stellate cells. This complex interplay between the several cell types involved in liver cancer emphasizes the need for targeting the tumor stroma in HCC patients. | Femke Heindryckx Pär Gerwins | 2015 | World Journal of Hepatology2015，7，2： | 16 |
| 2 | Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis显示文摘 | Gerwins P Skoldenberg E Claesson-Welsh L | 2004 | Critical Reviews in Oncoy/Hematol2004，34，： | 1 |
| 3 | Function of fibroblast growth factor and VEGF and their receptors in angiogenesis显示文摘 | Skoidenberg E Claesson Welsh L | 2000 | Crit Rev Oncol Hematol2000，34，3： | 1 |
| 4 | Activation of mitogen-activated protein kinases in experimental cerebral ischemia显示文摘 | Lennmyr F Karlsson S Gerwins P | 2002 | Acta Neurol Scand2002，106，6： | 1 |
| 5 | A new mechanism of blood vessel growth-hope for new treatment strategies显示文摘 | Kilarski WW Gerwins P | 2009 | Discov Med2009，8，： | 1 |
| 6 | Activa-tion of mitogen activated Protein kinases in experi-mental cerebral ischemia 显示文摘 | Lennmyr F Karlsson S Gerwins P | 2002 | Acta Neurol Scand2002，106，6： | 1 |
| 7 | Activation of mitogen activated Protein kinases in experimental cere- bral ischemia显示文摘 | Lennmyr F Karlsson S Gerwins P | 2002 | Acta Neurol Scand2002，106，6： | 1 |
| 8 | Activation of mitogen-activated protein kinases in experimental cerebral ischemia显示文摘 | Lennmyr F Karlsson S Gerwins P | 2002 | Acta Neurol Scand2002，106，6： | 1 |
| 9 | Activation Of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide 显示文摘 | Nick JA Avdi N J Gerwins P | 1996 | J Immunol1996，156，12： | 1 |
| 10 | Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis显示文摘 | Gerwins P Skoldenberg E ClaessonWelsh L | 2000 | Crit Rev Oncol Hematol2000，34，3： | 1 |
| 11 | Cloning,expression analysis and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases 显示文摘 | LIGOS J M Gerwin N Fernandez P | 1998 | Biochemical and Biophysical Research Communication1998，249，： | 1 |
| 12 | Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis 显示文摘 | Skoldenberg E Claesson WL | 2000 | Crit Rev Oncol Hematol2000，34，3： | 1 |
| 13 | ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line显示文摘 | Gerwins P Fredholm BB | 1992 | J Biol Chem1992，267，16： | 1 |
| 14 | Function of fibroblast growth factor and VEGF and their receptor in angionesis显示文摘 | GERWINS P SKOIDENBERG E CLAESSON W I | 2000 | Crit Rev Oncol Hematol2000，34，3： | 1 |
| 15 | MEK kinase 1, a substrate for DEVD-Directed caspases,is involved in genotoxin-induced apoptosis 显示文摘 | Widmann C Gerwins P gohnson NL | 1998 | Mol Cell Biol1998，18，4： | 1 |
| 16 | Activation of mitogen-activated protein kinases in e xperimental cerebral ischemia显示文摘 | Lennmyr F Karlsson S Gerwins P | 2002 | Acta Neurol Scand2002，106，6： | 1 |
| 17 | Cloning of a novel mitogen-activated protein kinase kinase kinase,MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway显示文摘 | Gerwins P Black C L Johnson G L | 1997 | J Biol Chem1997，272，： | 1 |
| 18 | MEK kinase 1, a substrate for DEVDdirected caspases, is involved in genotoxininduced apoposis显示文摘 | WIDMANN C GERWINS P JOHNSON N L | 1998 | Mol Cell Biol1998，18，4： | 1 |
| 19 | Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis显示文摘 | Gerwins P Skoldenberg E Claesson Welsh L | 2000 | Crit Rev Oncol Hematol2000，34，3： | 1 |
| 20 | Activation of mitogen-activated protein kinases in experimental cerebral ischemia显示文摘 | Lennmyr F Karlsson S Gerwins P | 2002 | Acta Neurol Scand2002，106，6： | 1 |
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