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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Assessment of interactions of diverse ternary mixtures in an estrogen receptor-alpha reporter assay显示文摘 | Charles GD Gennings C Zaeharewski TR | 2002 | Toxicol Appl Pharmacol2002，180，1： | 1 |
| 3 | The solid regenerative circulation of leftover bits and pieces of magnesiumalloy显示文摘 | Yasumasa C Mamoru M Gen I | 2004 | Materia2004，43，4： | 1 |
| 4 | In-situ Ti-TiB metal-matrlx composite prepared by a reactive pressing process 显示文摘 | Ma Z Y Tjong S C Gen L | 2000 | Scripta Mater2000，42，4： | 1 |
| 5 | An automatic diagnosis method for the knee meniscus tears in MR images显示文摘 | K(o)se C Gen(c)alio(g)lu O (S)evik U | | 0，，02： | 1 |
| 6 | Randomized trial compa- ring daily interruption of sedation and nursing-implemented seda- tion algorithm in medical intensive care unit patients 显示文摘 | De wit M Gennings C Jenvey WI | 2008 | Crit Care2008，12，3： | 1 |
| 7 | Multistage productiondistribution under uncertain demands with integrated discreteparticle swarm optimization and extended prioritybasedhybrid genetic algorithm显示文摘 | Jamrus T Chien C F Gen M | 2015 | Fuzzy Optim DecisMaking2015，，： | 1 |
| 8 | Multirow machine layout problem in fuzzy environment using genetic algorithms 显示文摘 | Gen M Ida K Cheng C | 1995 | Computers and Industrial Engineering1995，29，1： | 1 |
| 9 | Children(s) and Adults'Conceptualization and Evaluation of Lying and Truth telling显示文摘 | Fen Xu Yang C Luo Gen yue Fu Kang Lee | | 0，，04： | 1 |
| 10 | The North American Study for the Treatment of Refratory Ascites 显示文摘 | Sanyal AJ Genning C Reddy KR | 2003 | Gastroenterology2003，124，3： | 1 |
| 11 | Adsorption ofarsenic from water using activated neutralized red mud 显示文摘 | Gen^-Fuhrmun H Tjell J C McConchie D | 2004 | Environmental Science and Technology2004，38，8： | 1 |
| 12 | Network modeling and evolu- tionary optimization for scheduling in manufacturing显示文摘 | Lin L Hao X C Gen M | 2012 | Jour- nal of Intelligent Manufacturing2012，23，6： | 1 |
| 13 | An approach for assessing estrogen receptor-mediated interactions in mixtures of three chemicals: a pilot study 显示文摘 | CHARLES G D GENNINGS C ZACHAREWSKI T R | 2002 | Toxicol Sci2002，68，： | 1 |
| 14 | Evaluation of whether the ACE gene I/D polymorphism constitutes a risk factor for chronic obstructive pulmonary disease in the Turkish population显示文摘 | Ayada C Toru U GenO | 2014 | Genet Mol Res2014，13，10： | 1 |
| 15 | Toxicological interactions among arsenic, cadmium, chromium, and lead in human kerationocytes 显示文摘 | Bae DS Gennings C Carter WH Jr | 2001 | Toxicol Sci2001，63，1： | 1 |
| 16 | An approach for assessing estrogen receptor-mediated interactions in mixtures of three chemicals: a pilot study显示文摘 | Charles GD Gennings C Zacharewski TR | 2002 | Toxicol Sci2002，68，： | 1 |
| 17 | In the QTL region surrounding porcine MHC gene order is conserved with human genome显示文摘 | Gen Renard C Cabau C | | 0，，： | 1 |
| 18 | Assessment o liver hydatid cyst cases-10 years experience in Turkey显示文摘 | Mergen H Gen H Tavusbay C | 2007 | Trop Doct2007，37，1： | 1 |
| 19 | The vitamin D3 analog,ILX-23-7553,enhances the responseto adriamycin and irradiation in MCF-7 breast tumor cells显示文摘 | Chaudhry M Sundaram S Gennings C | 2001 | Cancer Chemother Pharmacol2001，47，5： | 1 |
| 20 | The North American study for the treatment of refratory ascitcs显示文摘 | Sanyal AJ Genning C Reddy KR | 2003 | Gastroenterology2003，124，3： | 1 |
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