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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat显示文摘OBJECTIVE:To study on effects of Lichong decoction on expression of apoptosis-controlling genes,Bcl-2 and Bcl-2-associated X protein(Bax) mRNAs in hysteromyoma tissue of the hysteromyoma model rat.METHODS:Fifty Wistar female rats were randomly divided into a normal group,a model group,a Lichong decoction group,a Guizifuling capsule group and a Mifepristone group.The hysteromyoma rat model was established by intraperitoneal injection of exogenous estrin and progestogens.Pathological examination of uterine tissue,uterine coefficient and uterine transverse diameter were made under optic microscope and expressions of Bcl-2 and Bax mRNAs in uterine tissue in the groups were detected with real-time fluorescent quantitative polymerase chain reaction(PCR) technique.RESULTS:After treatment,under microscope it was found that in the Lichong decoction group myometrium thinned,muscle fiber slightly overgrowth or long and thin,regular arrangement,inserting phenomenon of inner circular muscle and external longitudinal muscle was occasionally or not seen in the Lichong decoction group.The uterine coefficient and the uterine transverse diameter significantly decreased(P<0.01),and Bcl-2 mRNA expression significantly decreased(P<0.01) and Bax mRNA expression significantly increased in hysteromyoma tissue(P<0.01) in the Lichong decoction group as compared with the model group.CONCLUSION:Therapeutic effects of Lichong decoction on hysteromyoma is related with decrease of Bcl-2 mRNA expression and increase of Bax mRNA expression. | Donghua Li Xin Xu Ruiya Qian Jianguo Geng Yan Zhang Xiaolei Xie Yasong Wang Xiaoli Zou | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 24 |
| 3 | Emodin protects rat liver from CCl_4-induced fibrogenesis via inhibition of hepatic stellate cells activation显示文摘AIM:To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl4) in rats and to further explore the underlying mechanisms.METHODS: Rat models of experimental hepatic fibrosis were established by injection with CCl4; the treated rats received emodin via oral administration at a dosage of 20 mg/kg twice a week at the same time. Rats injected with olive oil served as a normal group. Histopathological changes were observed by hematoxylin and eosin staining. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and hepatic hydroxyproline content were assayed by biochemical analyses. The mRNA and protein relevant to hepatic stellate cell (HSC) activation in the liver were assessed using real-time reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, western blotting and enzyme-linked immunosorbent assay.RESULTS: The degree of hepatic fibrosis increased markedly in the CCl4 group compared to the normal group (P<0.01), and decreased markedly in the emodin group compared to the CCl4 group according to METAVIR scale (P<0.01) compared with those in the normal control group (51.02±10.64 IU/L and 132.28±18.14 IU/L). The activities of serum ALT and AST were significantly higher in rats injected with CCl4 (289.25±68.84 IU/L and 423.89±35.67 IU/L, both P<0.05). The activities of serum ALT and AST were significantly reduced by administration of emodin (176.34±47.29 IU/L and 226.1±44.52 IU/L, both P<0.05). Compared with the normal controls (54.53±13.46 mg/g), hepatic hydroxyproline content was significantly higher in rats injected with CCl4 (120.27±28.47 mg/g, P<0.05). Hepatic hydroxyproline content was significantly reduced in the rats treated with emodin at 20 mg/kg (71.25±17.02 mg/g, P<0.05). Emodin signif icantly protected the liver from injury by reducing serum AST and ALT activities and reducing hepatic hydroxyproline content. The mRNA levels of transforming growth factor-β1 (TGF-β1), Smad4 and α-SMA in liver tissues were significantly down-regulated in SD rats that received emodin treatment. Furthermore, significant down-regulation of serum TGF-β1 protein levels and protein expression of Smad4 and α-SMA in liver tissues was also observed in the rats. Emodin inhibited HSC activation by reducing the abundance of TGF-β1 and Smad4.CONCLUSION: Emodin protects the rat liver from CCl4-induced fibrogenesis by inhibiting HSC activation. Emodin might be a therapeutic antifibrotic agent for the treatment of hepatic fibrosis. | Miao-Xian Dong Yan Jia Ying-Bo Zhang Cheng-Chong Li Yu-Tao Geng Li Zhou Xue-Yan Li Ji-Cheng Liu Ying-Cai Niu | 2009 | World Journal of Gastroenterology2009，15，38： | 22 |
| 4 | Atomically dispersed Au_1 catalyst towards efficient electrochemical synthesis of ammonia显示文摘Tremendous efforts have been devoted to explore energy-efficient strategies of ammonia synthesis to replace Haber–Bosch process which accounts for 1.4% of the annual energy consumption. In this study,atomically dispersed Au_1 catalyst is synthesized and applied in electrochemical synthesis of ammonia under ambient conditions. A high NH_4^+ Faradaic efficiency of 11.1% achieved by our Au_1 catalyst surpasses most of reported catalysts under comparable conditions. Benefiting from efficient atom utilization, an NH_4^+ yield rate of 1,305 lg h^(-1) mg_(Au)^(-1) has been reached, which is roughly 22.5 times as high as that by supported Au nanoparticles. We also demonstrate that by employing our Au_1 catalyst, NH4+can be electrochemically produced directly from N_2 and H_2 with an energy utilization rate of 4.02 mmol kJ^(-1). Our study provides a possibility of replacing the Haber–Bosch process with environmentally benign and energy-efficient electrochemical strategies. | Xiaoqian Wang Wenyu Wang Man Qiao Geng Wu Wenxing Chen Tongwei Yuan Qian Xu Min Chen Yan Zhang Xin Wang Jing Wang Jingjie Ge Xun Hong Yafei Li Yuen Wu Yadong Li | 2018 | Science Bulletin2018，63，19： | 22 |
| 5 | Pathways of China's PM;air quality 2015–2060 in the context of carbon neutrality显示文摘Clean air policies in China have substantially reduced particulate matter(PM;) air pollution in recent years,primarily by curbing end-of-pipe emissions.However,reaching the level of the World Health Organization(WHO) guidelines may instead depend upon the air quality co-benefits of ambitious climate action.Here,we assess pathways of Chinese PM;air quality from 2015 to 2060 under a combination of scenarios that link global and Chinese climate mitigation pathways(i.e.global 2℃-and 1.5℃-pathways,National Determined Contributions(NDC) pledges and carbon neutrality goals) to local clean air policies.We find that China can achieve both its near-term climate goals(peak emissions) and PM;air quality annual standard(35 μg/m;) by 2030 by fulfilling its NDC pledges and continuing air pollution control policies.However,the benefits of end-of-pipe control reductions are mostly exhausted by 2030,and reducing PM;exposure of the majority of the Chinese population to below 10 μg/m;by 2060 will likely require more ambitious climate mitigation efforts such as China’ s carbon neutrality goals and global1.5℃-pathways.Our results thus highlight that China’s carbon neutrality goals will play a critical role in reducing air pollution exposure to the level of the WHO guidelines and protecting public health. | Jing Cheng Dan Tong Qiang Zhang Yang Liu Yu Lei Gang Yan Liu Yan Sha Yu Ryna Yiyun Cui Leon Clarke Guannan Geng Bo Zheng Xiaoye Zhang Steven JDavis Kebin He | 2021 | National Science Review2021，8，12： | 23 |
| 6 | Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation显示文摘化疗经常被知道导致严重的胃肠的道毒性,但是内在的机制仍然保持不清楚。这研究作为一个代表性的代理人认为广泛地应用的细胞毒素的代理人是 irinotecan (CPT-11 ) 并且证明治疗从说明混合物的限制剂量的肠的毒性的肠导致双海滨 DNA 的巨大的版本。明确地,通过 exosome 分泌物释放的 self-DNA 进入天生的有免疫力的房间的 cytosol 并且激活 AIM2 (在黑瘤 2 不在) inflammasome。这导致成熟 IL-1 和 IL-18 分泌物并且导致肠的 mucositis 和迟了发作的腹泻。有趣地,在 AIM2 缺乏的老鼠或由象镇静药那样的一个药理学禁止者,没有影响 CPT-11 的 anticancer 功效, AIM2 发信号的废除显著地减少导致药的腹泻的发生。这些调查结果提供化疗怎么触发引起肠的毒性的天生的有免疫力的回答的机械学的卓见,并且揭示维持反瘤效果,但是围绕联系不利煽动性的反应的新化疗政体。 | Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu | 2017 | Cell Research2017，27，6： | 18 |
| 7 | Combination of serum inhibin B and follicle-stimulating hormone levels can not improve the diagnostic accuracy on testicular sperm extraction outcomes in Chinese non-obstructive azoospermic men显示文摘 | HUANG Xiang BAI Quan YAN Li-ying ZHANG Qiu-fang GENG Li QIAO Jie | 2012 | Chinese Medical Journal2012，，16： | 17 |
| 8 | Improved grey prediction model based on exponential grey action quantity显示文摘With the passage of time, it has become important to investigate new methods for updating data to better fit the trends of the grey prediction model. The traditional GM(1,1) usually sets the grey action quantity as a constant. Therefore, it cannot effectively fit the dynamic characteristics of the sequence, which results in the grey model having a low precision. The linear grey action quantity model cannot represent the index change law. This paper presents a grey action quantity model, the exponential optimization grey model(EOGM(1,1)), based on the exponential type of grey action quantity; it is constructed based on the exponential characteristics of the grey prediction model. The model can fully reflect the exponential characteristics of the simulation series with time. The exponential sequence has a higher fitting accuracy. The optimized result is verified using a numerical example for the fluctuating sequence and a case study for the index of the tertiary industry's GDP. The results show that the model improves the precision of the grey forecasting model and reduces the prediction error. | YIN Kedong GENG Yan LI Xuemei | 2018 | Journal of Systems Engineering and Electronics2018，29，3： | 14 |
| 9 | Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrheapredominant irritable bowel syndrome显示文摘BACKGROUND Visceral hypersensitivity is considered to play a vital role in the pathogenesis of irritable bowel syndrome(IBS). Neurotrophins have drawn much attention in IBS recently. Brain-derived neurotrophic factor(BDNF) was found to mediate visceral hypersensitivity via facilitating sensory nerve growth in pre-clinical studies. We hypothesized that BDNF might play a role in the pathogenesis of diarrhea-predominant IBS(IBS-D).AIM To investigate BDNF levels in IBS-D patients and its role in IBS-D pathophysiology.METHODS Thirty-one IBS-D patients meeting the Rome IV diagnostic criteria and 20 ageand sex-matched healthy controls were recruited. Clinical and psychological assessments were first conducted using standardized questionnaires. Visceral sensitivity to rectal distension was tested using a high-resolution manometry system. Colonoscopic examination was performed and four mucosal pinch biopsies were taken from the rectosigmoid junction. Mucosal BDNF expression and nerve fiber density were analyzed using immunohistochemistry. Mucosal BDNF mRNA levels were quantified by quantitative real-time polymerase chain reaction. Correlations between these parameters were examined.RESULTS The patients had a higher anxiety score [median(interquartile range), 6.0(2.0-10.0) vs 3.0(1.0-4.0), P = 0.003] and visceral sensitivity index score [54.0(44.0-61.0)vs 21.0(17.3-30.0), P < 0.001] than controls. The defecating sensation threshold[60.0(44.0-80.0) vs 80.0(61.0-100.0), P = 0.009], maximum tolerable threshold[103.0(90.0-128.0) vs 182.0(142.5-209.3), P < 0.001] and rectoanal inhibitory reflex threshold [30.0(20.0-30.0) vs 30.0(30.0-47.5), P = 0.032] were significantly lower in IBS-D patients. Intestinal mucosal BDNF protein [3.46 E-2(3.06 E-2-4.44 E-2) vs3.07 E-2(2.91 E-2-3.48 E-2), P = 0.031] and mRNA [1.57(1.31-2.61) vs 1.09(0.74-1.42), P = 0.001] expression and nerve fiber density [4.12 E-2(3.07 E-2-7.46 E-2) vs1.98 E-2(1.21 E-2-4.25 E-2), P = 0.002] were significantly elevated in the patients.Increased BDNF expression was positively correlated with abdominal pain and disease severity and negatively correlated with visceral sensitivity parameters.CONCLUSION Elevated mucosal BDNF may participate in the pathogenesis of IBS-D via facilitating mucosal nerve growth and increasing visceral sensitivity. | Yu Zhang Geng Qin De-Rong Liu Yan Wang Shu-Kun Yao | 2019 | World Journal of Gastroenterology2019，25，2： | 14 |
| 10 | Binding Activity Difference of Anti-CD20 scFv-Fc Fusion Protein Derived from Variable Domain Exchange显示文摘Two novel engineered antibody fragments binding to antigen CD20 were generated by fusing a murine IgM-type anti-CD20 single-chain Fv fragment (scFv) to the human IgG1 CH2 (i.e., Cγ2) and CH3 (i.e., Cγ3) domains with the human IgG1 hinge (i.e. Hγ). Given the relationship between structure and function of protein, the 3-D structures of the two engineered antibody fragments were modeled using computer-aided homology modeling method. Furthermore, the relationship between 3-D conformation and their binding activity was evaluated theoretically. Due to the change of active pocket formed by CDRs, the HL23 (VH-Linker-VL-Hγ-Cγ2-Cγ3) remained its activity because of its preserved conformation, while the binding activity of the LH23 (VL-Linker-VH-Hγ-Cγ2-Cγ3) was impaired severely. Experimental studies by flow cytometry and fluorescence microscopy showed that HL23 possessed significantly superior binding activity to CD20-expressing target cells than LH23. That is to say, the order of variable regions could influence the binding activity of the fusion protein to CD20+ cell lines, which was in accordance with the theoretical results. The study highlights the potential relationship between the antibody binding activity and their 3-D conformation, which appears to be worthwhile in providing direction for future antibody design of recombinant antibody. | Shusheng Geng Jiannan Feng Yan Li Yingxun Sun Xin Gu Ying Huang Yugang Wang Xianjiang Kang Hong Chang Beifen Shen | 2006 | Cellular & Molecular Immunology2006，3，6： | 13 |
| 11 | Impact of Long-Term Atrazine Use on Groundwater Safety in Jilin Province, China显示文摘The long-lasting application of representative herbicide atrazine (ATR) has given rise to the accumulation of its residues in the groundwater. To investigate the impact of long-term ATR use on groundwater safety, the residues of ATR and its metabolites, desethylatrazine (DEA), deisopropylatrazine (DIA) and hydroxyatrazine (HA) were monitored in groundwater and top soil at the major corn growing region of Qian'an and Gongzhuling in Jilin Province, China. The residues of the target compounds were analyzed by UPLC-MS/MS. The limits of detection (LODs) of ATR, DEA, DIA, and HA were 0.5, 0.5, 5, and 0.5 ng L-1 in groundwater and 0.33, 0.33, 3.3, and 0.33 μg kg-1 in soil. The target compounds were found in 94% of groundwater samples and 100% of soil samples. The compounds detected most frequently in groundwater were ATR (89%), DEA (64%) and HA (17%), whereas in soil were ATR (97%), DEA (36%) and HA (97%). DIA was not detected in any determined groundwater and soil sample. Average residues were 106.8 ng L-1 for ATR, 0.9 ng L-1 for DEA and 0.3 ng L-1 for HA in groundwater, whereas 11.1 μg kg-1 for ATR, 0.4 μg kg-1 for DEA and 7.8 μg kg-1 for HA in soil. ATR residues detected in groundwater samples were below standards for drinking water quality (GB5749-2006, 2 μg L-1), while the total residues of ATR and its chloro-s-triazine metabolites (DEA and DIA) were below current WHO (World Health Organization) guideline value (GV, 0.1 mg L-1). In addition, concentrations of HA in groundwater were determined below current WHO GV (0.2 mg L-1). The results indicated that ATR is safe to be used in Jilin Province under the current application scheme. However, total residues of ATR and DEA were detected in nearly all wells, thus, it is necessary to pay attention on groundwater monitoring for ATR and its metabolites. | GENG Yue MA Jing JIA Ran XUE Li-qin TAO Chuan-jiang LI Chong-jiu MA Xiao-dong LIN Yan | 2013 | Journal of Integrative Agriculture2013，12，2： | 13 |
| 12 | Seroepidemiological Investigation of Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China显示文摘Objective Lyme disease and Human granulocytic anaplasmosis are tick‐borne diseases caused by Borrelia burgdorferi and Anaplasma phagocytophilum respectively. We have investigated infection and co-infection of the two diseases in the population of forest areas of eight provinces in China by measuring seroprevalence of antibodies against B. burgdorferi and A. phagocytophilum. Methods Forest areas in 8 provinces were chosen for investigation using whole sampling and questionnaire survey methods. 3 669 serum samples from people in the forest areas were tested for the presence of antibodies by indirect immunofluorescent assay (IFA). Results Seroprevalence against B. burgdorferi was 3% to 15% and against A. phagocytophilum was 2% to 18% in the study sites in the 8 provinces in China. We also found co-infection of B. burgdorferi and A. phagocytophilum in 7 of the 8 provinces (the exception being the Miyun area in Beijing). The seroprevalence for both B. burgdorferi and A. phagocytophilum was significantly higher among people exposed to ticks than among people who were not exposed to ticks. Conclusion We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces. | HAO Qin GENG Zhen HOU Xue Xia TIAN Zhen YANG Xiu Jun JIANG Wei Jia SHI Yan ZHAN Zhi Fei LI Guo Hua YU De Shan WANG Hua Yong XU Jian Guo WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 13 |
| 13 | Soil respiration is driven by fine root biomass along a forest chronosequence in subtropical China显示文摘Aims Soil respiration(Rs)is a major process controlling soil carbon loss in forest ecosystems.However,the underlying mechanisms leading to variation in Rs along forest successional gradients are not well understood.In this study,we investigated the effects of biotic and abiotic factors on Rs along a forest successional gradient in southeast China.Methods We selected 16 plots stratified by forest age,ranging from 20 to 120 years.In each plot,six shallow collars and six deep collars were permanently inserted into the soil.Shallow and deep collars were used to measure Rs and heterotrophic respiration(Rh),respectively.Autotrophic soil respiration(Ra)was estimated as the difference between Rs and Rh.Litter layer respiration(R_(L))was calculated by subtracting soil respiration measured in collars without leaf litter layer(R_(NL))from Rs.Rs was measured every 2 months,and soil temperature(ST)and soil volumetric water content(SVWC)were recorded every hour for 19 months.We calculated daily Rs using an exponential model dependent on ST.Daily Rs was summed to obtain cumulative annual Rs estimates.Structural equation modelling(SEM)was applied to identify the drivers of Rs during forest succession.Important Findings Rs showed significant differences among three successive stages,and it was the highest in the young stage.Ra was higher in the young stage than in the medium stage.Cumulative annual Rs and Ra peaked in the young and old stages,respectively.Cumulative annual Rh and respiration measured from soil organic matter(R_(SOM))decreased,whereas R_(L)increased with forest age.The SEM revealed that cumulative annual Rs was influenced by fine root biomass and SVWC.Our results indicated that the dominant force regulating Rs on a seasonal scale is ST;however,on a successional scale,belowground carbon emerges as the dominant influential factor. | Chao Wang Yinlei Ma Stefan Trogisch Yuanyuan Huang Yan Geng Michael Scherer-Lorenzen Jin-Sheng He | 2017 | Journal of Plant Ecology2017，10，1： | 13 |
| 14 | A modified protocol with rituximab and intravenous immunoglobulin in emergent ABO-incompatible liver transplantation for acute liver failure显示文摘BACKGROUND: The established procedure for ABO-incompatible liver transplantation(ABO-I LT) was too complicated to be used in case of emergency. We developed a protocol consisting of rituximab and intravenous immunoglobulin(IVIG) for ABO-I LT in patients with acute liver failure(ALF).METHODS: The data from 101 patients who had undergone liver transplantation(LT) for ALF were retrospectively analyzed.The patients were divided into two groups: ABO-compatible liver transplantation group(ABO-C LT, n=66) and ABO-I LT group(n=35). All the patients in the ABO-I LT group received a single dose of rituximab(375 mg/m2) and IVIG(0.4 g/kg per day) at the beginning of the operation. IVIG was administered for 10 consecutive days after LT. Plasma exchange, splenectomy and graft local infusion were omitted in the protocol.Quadruple immunosuppressive therapy including basiliximab,corticosteroids, tacrolimus and mycophenolatemofetil was used to reinforce immunosuppression.RESULTS: The 3-year cumulative patient survival rates in the ABO-I LT and ABO-C LT groups were 83.1% and 86.3%,respectively(P>0.05), and the graft survival rates were 80.0%and 86.3%, respectively(P>0.05). Two patients(5.7%) suffered from antibody-mediated rejection in the ABO-I LT group.Other complications such as acute cellular rejection, biliary complication and infection displayed no significant differences between the two groups.CONCLUSIONS: The simplified treatment consisting of rituximab and IVIG prevented antibody-mediated rejection for LT of blood-type incompatible patients. With this treatment, the patients did not need plasma exchange, splenectomy and graft local infusion. This treatment was safe and efficient for LT of the patients with ALF. | Tian Shen Bing-Yi Lin Jun-Jun Jia Zhuo-Yi Wang Li Wang Qi Ling Lei Geng Sheng Yan Shu-Sen Zheng | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 11 |
| 15 | Ultrasound-guided continuous adductor canal block for analgesia after total knee replacement显示文摘 | Zhang Wei Hu Yan Tao Yan Liu Xuebing Wang Geng | 2014 | Chinese Medical Journal2014，，23： | 11 |
| 16 | Technical and environmental efficiency of hog production in China—A stochastic frontier production function analysis显示文摘This article analyses the technical and environmental efficiency of hog production in China using data from the China Agricultural Product Cost-Benefit Compilation(NDRC 2005–2013) and the First National Census of Pollution: Manual of Discharge Coefficient of Livestock and Poultry Industry(IEDA and NIES 2009). The empirical results show a great variation in environmental efficiency, ranging from 0.344 to 0.973 with a mean value of 0.672 that declines over time. Southwest China is found to be the most environmentally efficient region, while the Northeast and the Northwest are the least efficient. Another finding is that technical and environmental efficiencies are highly correlated in hog production; the most environmentally efficient regions are usually found to have high technical efficiency, and vice versa. In addition, we computed the output elasticities with respect to each factor input. The results show that feed is the most efficient input, with an output elasticity of approximately 0.551, which is much higher than the elasticity of the nitrogen surplus, other capital or labour. The output elasticity with respect to the nitrogen surplus is 0.287 on average. Finally, the scale elasticity in hog production is slightly higher than 1. | ZHOU Ying-heng ZHANG Xiao-heng TIAN Xu GENG Xian-hui ZHANG Peng YAN Bin-jian | 2015 | Journal of Integrative Agriculture2015，14，6： | 11 |
| 17 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 18 | Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3显示文摘Modiled citrus pectin (MCP) is a carbohydrate enriched complex, which has been implicated in cancer treatment and prevention. However, the effects of MCP on urinary bladder cancer (UBC) are unknown. In this study, MCP was first tested in T24 and J82 human UBC cells and showed the inhibition of cell viability by the sulforhodamine B (SRB) assay. The MCP-treated UBC cells exhibited G2/M phase arrest with the decrease of Cyclin B1 and phosphorylated Cdc2. Caspase-3 was also activated, leading to the cleavage of Caspase-3 and PARP. We further explored the possible molecular mechanisms upon MCP treatment in UBC cells. Reduction of galectin-3 was observed and followed with the inactivation of Akt signaling pathway. Of note, galectin-3 knockdown by RNA interference recapitulated the MCP-mediated anti-proliferation, cell cycle arrest and apoptosis. Moreover, oral administration of MCP to the T24 xenograft-bearing nude mice inhibited the tumor growth significantly (P<0.05). Quantification analysis of immunohistochemistry staining for Ki67 and cleaved Caspase-3 confirmed the decrease of proliferation index (P<0.05) and the increase of apoptosis index (P<0.01) in 700 mg/kg MCP-fed UBC xenografts. Using the information from TCGA database, we revealed that the overexpression of galectin-3 was associated with high tumor grade with lymph node metastasis, poor overall survival in UBC patients. Considering the remarkable inhibitory effects of MCP on UBC cell proliferation and survival in vitro and in vivo mainly through galectin-3, which is upregulated in UBCs, MCP may become an attractive agent, as a natural dietary fiber, for prevention and therapy of UBCs. | Tian Fang Dan-dan Liu He-ming Ning Dan Liu Jing-ya Sun Xiao-jing Huang Yu Dong Mei-yu Geng Shi-feng Yun Jun Yan Rui-min Huang | 2018 | Acta Pharmacologica Sinica2018，39，12： | 10 |
| 19 | Lower Es3 in Zhanhua Sag, Jiyang Depression: a case study for lithofacies classification in lacustrine mud shale显示文摘湖相页岩油气重点关注富含Ⅰ或Ⅱ_1型有机质纹层状灰质岩相,因此,泥页岩岩相划分除了应考虑矿物组分、层理构造之外,还应特别重视有机质类型及丰度的差异。以济阳坳陷沾化凹陷沙三下亚段(Es_3~下)湖相泥页岩为例,综合利用岩心描述、薄片、电镜、核磁及测井等资料进行岩相类型划分、特征分析及识别方法研究。首先,从层理构造、岩性角度区分泥页岩岩相,并考虑将有机质信息融入到岩相分类中,提出了'构造+岩性+有机质'三重信息结合的湖相泥页岩岩相划分方案。然后,针对岩相三重信息分别进行识别研究,利用测井变量最优滤波分析获得的敏感测井数据三维交会可提高岩性识别精度,同时鉴于曲线分形对层理构造有较好的指示,将敏感无铀伽马曲线分形维数作为交会变量,优化了岩相构造识别方法。最后,通过测井反演的有机碳含量(TOC)、热解烃(S_2)地化参数,进一步可得到氢指数(HI),借助氢指数-最大热解峰温度(HI-T_(max))图版能够识别不同岩相中的有机质类型。由此综合建立的湖相泥页岩岩相测井精细分析方法,能够准确地提取泥页岩岩相中构造、岩性、有机质三种信息,为在连续井筒中识别有效页岩储层与寻找油气甜点提供了依据。 | Yan Jian-Ping He Xu Hu Qin-Hong Liang Qiang Tang Hong-Ming Feng Chun-Zhen Geng Bin | 2018 | Applied Geophysics2018，15，2： | 10 |
| 20 | The construction of a genetic linkage map of non-heading Chinese cabbage (Brassica campestris ssp.chinensis Makino)显示文摘Non-heading Chinese cabbage(Brassica campestris ssp.chinensis Makino) is one of the most important vegetables in eastern China.A genetic linkage map was constructed using 127 doubled haploid(DH) lines,and the DH population was derived from a commercial hybrid 'Hanxiao'(lines SW-13 × L-118).Out of the 614 polymorphic markers,43.49% were not assigned to any of the linkage groups(LGs).Chi-square tests showed that 42.67% markers were distorted from expected Mendelian segregation ratios,and the direction of distorted segregation was mainly toward the paternal parent L-118.After sequentially removing the markers that had an interval distance smaller than 1 cM from the upper marker,the overall quality of the linkage map was increased.Two hundred and sixty-eight molecular markers were mapped into 10 LGs,which were anchored to the corresponding chromosome of the B.rapa reference map based on common simple sequence repeat(SSR) markers.The map covers 973.38 cM of the genome and the average interval distance between markers was 3.63 cM.The number of markers on each LG ranged from 18(R08) to 64(R07),with an average interval distance within a single LG from 1.70 cM(R07) to 6.71 cM(R06).Among these mapped markers,169 were sequence-related amplified polymorphism(SRAP) mo-lecular markers,50 were SSR markers and 49 were random amplification polymorphic DNA(RAPD) markers.With further saturation to the LG,the current map offers a genetic tool for loci analysis for important agronomic traits. | Yan Cheng Jianfeng Geng Jingyi Zhang Qian Wang Qingyu Ban Xilin Hou | 2009 | Journal of Genetics and Genomics2009，36，8： | 9 |
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