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279篇 您的检索式:作者名="GAUTAM M"
    题名 作者 年代 出处 被引量
1Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition.Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar 2015World Journal of Gastroenterology2015,21,43:36
2Antiarthritic effects of Ajuga bracteosa Wall ex Benth.in acute and chronic models of arthritis in albino rats显示文摘Objective:To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats.Methods: The antiarthritic activity of 70%ethanolic extract of Ajuga bracteosa(EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund's adjuvant(CFA)-induced chronic immunological arthritis in albino rats.Results:EEAB showed a significant(P<0.05) and dose dependent inhibitory effect against acute and chronic models of arthritis.EEAB exhibited better antiarthritic activity than the standard aspirin.Conclusions: EEAB exhibits a significant and promising antiarthritic activity against acute and chronic arthritis and supports the traditional use of Ajuga bracteosa for rheumatism and other inflammatory diseases.Gaurav Kaithwas Raju Gautam Sanjay M Jachak Arvind Saklani 2012Asian Pacific Journal of Tropical Biomedicine2012,2,3:3
3Comparative study of cere- brospinal fluid adenosine deaminase activity in patients with men ingitis显示文摘Gautam N Aryal M Bhatta N 2007Nepal Med Coll2007,9,2:1
4p53-Immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats显示文摘Li Y Chopp M Zhang ZG Zaloga C Niewenhuis L Gautam S 1994Stroke1994,25,4:1
5Web crawlers:Evaluation adaptive algorithms显示文摘FILIPPO M GAUTAM P PADMINI S 2004ACM Transaction on Internet Technology2004,4,4:1
6Repeat needle biopsies combined with clinical observation are safe and accurate in the management of a solitary pulmonary nodule显示文摘Welker JA Alattar M Gautam S 2005Cancer2005,103,3:1
7Diagnostic utility of adenosine deaminase(ADA) activity in pleural fluid and serum of tuberculotus and non-tuberculous respiratory disease patients显示文摘Lamsal M Gautam N Bhatta N 0,,:1
8Cardiogenic shock complicating acute,myocardial infarction-a review显示文摘Dubey L Sharma S Gautam M 2011Acta Cardiol2011,66,6:1
9Gamma irradiation of municipal sludge for safe disposal and agricultural use显示文摘GAUTAM S SHAH M R SABHARWAL S 2005Water Environment Research2005,77,5:1
10Expression of monocyte chemoattractant protent-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat显示文摘Kim J S Gautam S C Chopp M 1995Neuroimmunol1995,56,2:1
11Role of C-Reactive Protein in HIV Infection:A Pilot Study显示文摘Chaudhary M Kashyap B Gautam H 0,,02:1
12Origin assessment of domestic and imported beef sold in the Korean markets using stable carbon and oxygen isotopes显示文摘BONG Y-S GAUTAM M K LEE K-S 0,,01:1
13Cardiogenic shock compli- cating acute myocardial infarction-a review显示文摘Dubey L Sharma S Gautam M 2011Acta Cardio12011,66,6:1
14Women in medicine: stress and solutions 显示文摘Gautam M 2001Western Journal of Medicine2001,174,:1
15Multisystem failure due to three coexisting autoimmune diseases显示文摘Pillai A Gautam M Williamson H 2009Internal Medicine2009,48,10:1
16Prevalence of endometritis during the postpartum period and its impact on subsequent reproductive performance in two Japanese dairy herds显示文摘Gautam G Nakao T Yusuf M 2009Animal reproduction science2009,116,34:1
17Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase - containing neurons afrer focal cerebral ischemia in rat 显示文摘Zhang ZG Chopp M Gautams S 1994Brain Res1994,654,:1
18Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat显示文摘Zhang ZG Chopp M Gautam S 1994Brain Res1994,654,1:1
19Comparison of interviewed and non-interviewed non-Hodgkin's lymphoma (NHL) patients in the San Francisco Bay Area显示文摘Holly EA Gautam M Bracci PM 2002Ann Epidemiol2002,12,6:1
20Association of CD36 gene variants rs1761667 (G > A) and rs1527483 (C > T) with Type 2 dia- betes in Noah Indian population显示文摘Banerjee M Gautam S Saxena M 2010International Journal of Diabe- tes Mellitus2010,2,3:1
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