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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Why benchmark-quality computations are needed to reproduce 1-adamantyl cation NMR chemical shifts accurately显示文摘 | Harding M E Gauss J Schleyer P | 2011 | J Phys Chem A2011，115，11： | 1 |
| 3 | Radioactive forcing since preindustrial times due to ozone changes in troposphere and the lower stratosphere显示文摘 | Gauss M Myhre G Isaksen I S A | 2006 | Atmospheric Chemistry and Physics2006，6，： | 1 |
| 4 | Radiative forcing since preindustrial times due to ozone change in the troposphere and the lower stratosphere显示文摘 | Gauss M Myhre G Isaksen I SA | 2006 | Atmospheric Chemistry and Physics2006，6，3： | 1 |
| 5 | Interob- server agreement for the detection of atherosclerotie plaque in coronary CT angiography: comparison of two low dose image acquisition protocols with standard retrospectively ECG-gated reconstruction 显示文摘 | SCHUHBACK A MARWAN M GAUSS S | 2012 | Eur Radiol2012，22，7： | 1 |
| 6 | Cerebral blood flow velocities in extremely low birth weight infants with hypotension and infants with normal blood pressure显示文摘 | LIGHTBURN M H GAUSS C H WILLIAMS D K | 2009 | J Pediatr2009，154，6： | 1 |
| 7 | Structure and regulation of the neu- trophil respiratory burst oxidase: comparison with nonphago- cyte oxidases显示文摘 | Quinn M T Gauss K A | 2004 | J Leukoc Biol2004，76，4： | 1 |
| 8 | Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases显示文摘 | Quinn M T Gauss K A | 2004 | J Leukoc Biol2004，76，4： | 1 |
| 9 | Fresh air in the 21st century 显示文摘 | PRATHER M GAUSS M BERNTSEN T | 2003 | Geophysical Research Letters2003，30，： | 1 |
| 10 | Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model显示文摘 | Beck-Broichsitter M Gauss J Packhaeuser CB | 2009 | Int J Pharm2009，367，12： | 1 |
| 11 | Type 1 interferons suppress accelerated osteoelastogenesis and prevent loss of bone mass during systemic inflammatory responses to Pneumocystis lung in- fection显示文摘 | Wilkison M Gauss K Ran Y | 2012 | Am J Pathol2012，181，1： | 1 |
| 12 | Analysis of the mouse proteome (I) Brain proteins: separation by two-di- mensional electrophoresis and identification by mass spec- trometry and genetic variation显示文摘 | Gauss C Kalkum M Lowe M | 1999 | Electrophoresis1999，20，3： | 1 |
| 13 | Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to pneumocystis lung infection显示文摘 | Wilkison M Gauss K Ran Y | 2012 | Am J Pathol2012，181，1： | 1 |
| 14 | Velocity ratio measurements of a gyrotron electron beam显示文摘 | Gauss W C Basten M A Kreischer K E | 1991 | J Appl Phys1991，69，7： | 1 |
| 15 | Encephalopathy and rhabdo- myolysis induced by iotrolan during epiduroscopy 显示文摘 | Mizuno J Gauss T Suzuki M | 2007 | Can J An- aesth2007，54，1： | 1 |
| 16 | The effects of intraabdominally insufflated carbon dioxide on hepatic blood flow during laparoscopic surgery assessed by transesophageal echocardiography显示文摘 | Rainer Meierhenrich M D Albrecht Gauss | 2005 | Anesth Analg2005，100，： | 1 |
| 17 | Encephalopathy and rhabdomyolysis induced by iotrolan during epiduroscopy 显示文摘 | Mizuno J Gauss T Suzuki M | 2007 | Can J Anesth2007，54，1： | 1 |
| 18 | Structure and regulation of the neutrophil respiratory burst oxidase:comparison with nonphagocyte oxidases显示文摘 | Quinn M T Gauss K A | 2004 | J Leukoc Biol2004，76，4： | 1 |
| 19 | Fostriecin: Chemistry and Biology 显示文摘 | Lewy D S Gauss C M Soenen D R | 2002 | Curr Med Chem2002，9，： | 1 |
| 20 | The effect of propofol and desflurane anaesthesia on human hepatic blood flow; a pilot study显示文摘 | Meierhenrich R Gauss A Mühling B | 2010 | Anaesthesia2010，65，11： | 1 |
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