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| 1 | Undrained shear strength evaluation for hydrate-bearing sediment overlying strata in the Shenhu area, northern South China Sea显示文摘The undrained shear strength of shallow strata is a critical parameter for safety design in deep-water operations.In situ piezocone penetration tests(CPTU) and laboratory experiments are performed at Site W18-19 in the Shenhu area, northern South China Sea, where China's first marine hydrate exploitation operation is due to be located. The validation of the undrained shear strength prediction model based on CPTU parameters. Different laboratory tests, including pocket penetrometer, torvane, miniature vane and unconsolidated undrained triaxial tests, are employed to solve empirical cone coefficients by statistical and mathematical methods. Finally, an optimized model is proposed to describe the longitudinal distribution of undrained shear strength in calcareous clay strata in the Shenhu area. Research results reveal that average empirical cone coefficients based on total cone resistance, effective resistance, and excess-pore pressure are 13.8, 4.2 and 14.4, respectively. The undrained shear strength prediction model shows a good fit with the laboratory results only within specific intervals based on their compaction degree and gas-bearing conditions. The optimized prediction model in piecewise function format can be used to describe the longitudinal distribution of the undrained shear strength for calcareous clay within all depth intervals from the mud-line to the upper boundary of hydrate-bearing sediments(HBS). The optimized prediction result indicates that the effective cone resistance model is suitable for very soft to firm calcareous clays,the excess-pore pressure model can depict the undrained shear strength for firm to very stiff but gas-free clays,while the total cone resistance model is advantageous for evaluating the undrained shear strength for very stiff and gassy clays. The optimized model in piecewise function format can considerably improve the adaptability of empirical models for calcareous clay in the Shenhu area. These results are significant for safety evaluations of proposed hydrate exploitation projects. | Yanlong Li Gaowei Hu Nengyou Wu Changling Liu Qiang Chen Chen'an Li | 2019 | Acta Oceanologica Sinica2019，38，3： | 12 |
| 2 | Experimental studies on the P-T stability conditions and influencing factors of gas hydrate in different systems显示文摘The P-T stability conditions of gas hydrate in different systems (i.e., solution, silica sand, and marine sediment) were studied using multi-step decomposition method with our experimental equipment. The effects of different ions with various concentrations and sediment grains on the P-T stability conditions of gas hydrate were investigated. The results show that different ions have different influences on the phase equilibrium of gas hydrate. However, the influence of ions is in a similar trend: the larger the concentration, the bigger the P-T curve shifts to the left. For the silica sand, the influence of pore capillarity of coarse particles (> 460 μm) can be negligible. The P-T curve measured in coarse silica is in agreement with that in pure water. However, the influence of pore capillarity of fine particles (< 35 μm) is significant. The maximum reduction value of temperature is 1.5 K for methane hydrate under stable state. The sediment from the South China Sea significantly affects the P-T stability conditions of methane hydrate, with an average reduction value of 1.9 K within the experimental conditions. This is mainly the result of both the pore water salinity and the pore capillarity of sediment. Because the pore water salinity is keeping diluted by the fresh water released from hydrate dissociation, the measured P-T stability points fall on different P-T curves with the decreasing salinity. | LIU ChangLing YE YuGuang SUN ShiCai CHEN Qiang MENG QingGuo HU GaoWei | 2013 | Science China Earth Sciences2013，56，4： | 11 |
| 3 | Mechanical Properties of Methane Hydrate-Bearing Interlayered Sediments显示文摘The complex distribution of gas hydrate in sediments makes understanding the mechanical properties of hydrate-bearing sediments a challenging task.The mechanical behaviors of hydrate-bearing interlayered sediments are still poorly known.A series of triaxial shearing tests were conducted to investigate the strength parameters and deformation properties of methane hydrate-bearing interlayered sediments at the effective pressure of 1 MPa.The results indicate that the stress-strain curves of hydrate-bearing interlayered sediments are significantly different from that of hydrate-bearing sediments.The peak strength,Young's modulus,initial yielding modulus,and failure mode are deeply affected by the methane hydrate distribution.The failure behaviors and mechanism of strain softening and hardening patterns of the interlayered specimens are more complicated than those of the integrated specimens.This study compares the different mechanical behaviors between integrated and interlayered specimens containing gas hydrate,which can serve as a reference for the prediction and analysis of the deformation behaviors of natural gas hydrate reservoirs. | DONG Lin LI Yanlong LIU Changling LIAO Hualin CHEN Guoqi CHEN Qiang LIU Lele HU Gaowei | 2019 | Journal of Ocean University of China2019，18，6： | 11 |
| 4 | Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)-associated endonuclease 9(CRISPR/Cas9) system has emerged as a promising technology for specific genome editing in many species. Here we constructed one vector targeting eight agronomic genes in rice using the CRISPR/Cas9 multiplex genome editing system. By subsequent genetic transformation and DNA sequencing, we found that the eight target genes have high mutation efficiencies in the T_0 generation. Both heterozygous and homozygous mutations of all editing genes were obtained in T_0 plants. In addition, homozygous sextuple, septuple, and octuple mutants were identified. As the abundant genotypes in T_0 transgenic plants, various phenotypes related to the editing genes were observed. The findings demonstrate the potential of the CRISPR/Cas9 system for rapid introduction of genetic diversity during crop breeding. | Lan Shen Yufeng Hua Yaping Fu Jian Li Qing Liu Xiaozhen Jiao Gaowei Xin Junjie Wang Xingchun Wang Changjie Yan Kejian Wang | 2017 | Science China(Life Sciences)2017，60，5： | 11 |
| 5 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 6 | Influence of foraminifera on formation and occurrence characteristics of natural gas hydrates in fine-grained sediments from Shenhu area, South China Sea显示文摘Marine gas hydrates accumulate primarily in coarse-grained, high-permeability layers; however, highly saturated natural gas hydrates have been discovered in the fine-grained sediments of Shenhu area, South China Sea(SCS). This may be explained by key factors, such as the great abundance of foraminifera shells. In this paper, by analyzing the SCS foraminifera structure and performing hydrate formation experiments in the foraminifera shells, the contribution of foraminifera to hydrate accumulation in the SCS was investigated from a microscopic point of view. Simulations of hydrate formation were carried out in both pure SCS foraminifera shells and the host sediments. Pore structures in typical foraminifera were studied by use of micro-focus X-ray computed tomography(CT) and scanning electron microscopy(SEM). Hydrate growth and occurrence characteristics in the foraminifera shells were observed in-situ. The results showed that the presence of foraminifera significantly enhanced the effective porosity of the SCS sediments. Moreover, while the hydrates grew preferentially in the chambers of the coarse-grained foraminifera by adhering to the inner walls of the foraminifera shells, no apparent hydrate accumulation was observed in the fine-grained or argillaceous matrix. These findings provide a basis for further studies on the accumulation mechanism of hydrates and physical properties of hydrate reservoir in the South China Sea. | LI ChengFeng HU GaoWei ZHANG Wei YE YuGuang LIU ChangLing LI Qing SUN JianYe | 2016 | Science China Earth Sciences2016，59，11： | 7 |
| 7 | Cathodic micro-arc electrodeposition of yttrium stabilized zirconia (YSZ) coatings on FeCrAl alloy显示文摘The formation of ceramic coatings on metal substrate by cathodic electrolytic deposition (CELD) has received more attention in recent years. But only thin filmscan be prepared via CELD. Yttrium stabilized zirconia (YSZ) ceramic coatings were deposited on FeCrAI alloy by a novel technique--cathodic micro-arc electrodeposition (CMED).The result shows that, when a high pulse electric field is applied to the cathode which was pre-deposited with a thin YSZ film, dielectric breakdown occurs and micro-arc discharges appear. Coatings with reasonably thickness of-300μm and crystalline structure can be deposited on the cathode by utilizing the energy of the micro-arc. The thickness of the as-deposited coating is dominated by the voltage and the frequency. Y2O3 is co-deposited with ZrO2 when Y(NO3)3 was added to the electrolyte, which stabilize t-phase, t′-phase and c-phase of ZrO2 at room temperature. The amount of the m-ZrO2 in the coating is diminished by increasing the concentration of Y(NO3)3 in the electrolyte.This report describes the processing of CMED and studies the microstructure of the deposited YSZ coatings. | YANGXiaozhan HEYedong WANGDeren GAOWei | 2003 | Chinese Science Bulletin2003，48，8： | 5 |
| 8 | Thermal performances of non-equidistant helical-coil phase change accumulator for latent heat storage显示文摘Helical-coil is a common structure of heat exchanger unit in phase change heat accumulator and usually has the equal coil pitch between adjacent coils.Its thermal performances Thus,could be improved by improving the uniformity was of unit the phase change material(PCM)temperature distribution.flow a novel non-equidistant helical-coil made structure heat proposed area in this study.Its coil pitch match decreased along the direction of heat transfer fluid,which the exchange in that volume increase to the decreasing temperature difference between was the heat transfer and fluid and PCM.The structure was optimized using numerical simulation.helical-coil temperature An heat experimental accumulator system was developed the experiment results indicated latent the proposed non-equidistant uniformity more effective than equidistant helical-coil for heat storage.The of the distribution was also confirmed by simulation results. | ZHANG GaoWei HU Peng LIU MingHou | 2017 | Science China(Technological Sciences)2017，60，5： | 5 |
| 9 | A high over-potential binder-free electrode constructed of Prussian blue and MnO2 for high performance aqueous supercapacitors显示文摘Extending the potential window of aqueous supercapacitors (SCs) up to 2.0 V is still a great challenge.Based on their good dynamic structural reversibility and open framework structure,the coordination superamolecular networks (CSNs) exhibit rapid charge/discharge ability and excellent cycle stability.As a typical coordination superamolecular network (CSN),Prussian blue (denoted as CSN-PB),which self-assembled by the CN-ligand and iron ions is firstly in-situ grown on carbon cloth,followed by electro-deposition of MnO2 to form CSN-PB/MnO2 composite electrode.Benefiting from synergistic effect of the constituent components,as well as the open framework structure of CSN-PB,this composite electrode reaches a high potential window of 1.4 V (vs.Ag/AgCl) and delivers a good specific capacitance of 315.3 F·g^-1 in aqueous electrolyte.An aqueous asymmetric device,constructed with CSN-PB/MnO2 composite as cathode and activated carbon as anode,can work in a stable potential window of 2.4 V,exhibits a high energy density of 46.13 Wh·kg^-1 and excellent cycling stability with 85.5% capacitance retention after 20,000 cycles.This work provides a new concept of high dynamic structural reversibility from CSNs to increase the cell voltage of asymmetric SCs for further boosting energy density. | Gaowei Zhang Hua Yao Feng Zhang Zitao Gao Qiujun Li Yangyi Yang Xihong Lu | 2019 | Nano Research2019，12，5： | 5 |
| 10 | Retraction Note to:SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion显示文摘The authors have retracted this article1.After the publication of this article,it came to the authors attention that in order to support the conclusions of the study,the authors should have used primary T cells instead of T-cell lines.In addition,there are concerns that the flow cytometry methodology applied here was flawed.These points resulted in the conclusions being considered invalid. | Xinling Wang Wei Xu Gaowei Hu Shuai Xia Zhiping Sun Zezhong Liu Youhua Xie Rong Zhang Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，8： | 5 |
| 11 | Characteristics of authigenic pyrite and its sulfur isotopes influenced by methane seep at Core A, Site 79 of the middle Okinawa Trough显示文摘The anaerobic oxidation of methane(AOM) has strongly developed at Core A, Site 79 of the middle Okinawa Trough, East China Sea, and a large amount of authigenic pyrite is preserved in the surface sediment. In this study, we analyze the characteristics of the authigenic pyrite and its sulfur isotopic values. The authigenic pyrite is stripy and tubular, and there were foraminifera compartments filled with pyrite. The pyrite is extracted using chromium reduction, and the values of ? 34 S are found to lie between ?41.20‰ and 8.92‰ V-CDT. The bulk pyrite tends to be more enriched in 34 S with increasing depth. Particularly, the ? 34 S value of the pyrite lies between ?32.73‰ and ?41.20‰ V-CDT above 278 cmbsf, but it quickly increases below this depth(?21.49‰–8.92‰ V-CDT). At the same time, the total sulfur content of the pyrite shows an abrupt increase above 100 cmbsf but is otherwise stable between 1.04% and 0.55% below 100 cmbsf. The stable and negative values of ? 34 S and the decreasing values of total sulfur above 278 cmbsf indicate reduced AOM activities in 17.18–5.3 ka. In addition, the increasing ? 34 S and pyrite content indicate strong AOM development and methane seep below 278 cmbsf in 18.8–17.18 ka. In particular, the highest positive value of ? 34 S occurring in 18.78 ka indicates the most intense AOM activity. The shallow sulfate-methane interface(SMI) and high methane flux below marine sediments also strongly support this activity. | WANG Meng CAI Feng LI Qing LIANG Jie YAN GuiJing DONG Gang WANG Feng SHAO HeBin HU GaoWei | 2015 | Science China Earth Sciences2015，58，12： | 4 |
| 12 | An aqueous zinc-ion hybrid super-capacitor for achieving ultrahigh-volumetric energy density显示文摘Zinc-ion hybrid super-capacitors are regarded as promising safe energy storage systems,However,the relatively low volumetric energy density has become the main bottlenecks in practical applications of portable electronic devices,In this work,the zinc-ion hybrid super-capacitor with high volumetric energy density and superb cycle stability had been constructed which employing the high-density threedimensional graphene hydrogel as cathode and Zn foil used as anode in 1 mol/L ZnSO4 electrolyte.Benefiting from the abundant ion transport paths and the abundant active sites for graphene hydrogel with high density and porous structure,the zinc-ion hybrid super-capacitor exhibited an extremely high volumetric energy density of 118.42 Wh/L and a superb power density of 24.00 kW/L,as well as an excellent long cycle life(80% retention after 30,000 cycles at 10 A/g),which was superior to the volumetric energy density of the reported zinc-ion hybrid super-capacitors.This device,based on the fast ion adsorption/deso rption on the capacitor-type graphene cathode and reversible Zn^(2+) plating/stripping on the battery-type Zn anode,which will inspire the development of zinc-ion hybrid super-capacitor in miniaturized devices. | Li Zhang Dandan Wu Gaowei Wang Yongtai Xu Hongxia Li Xingbin Yan | 2021 | Chinese Chemical Letters2021，32，2： | 4 |
| 13 | From Phage lambda to human cancer: endogenous molecular-cellular network hypothesis显示文摘 | Gaowei Wang Xiaomei Zhu Leroy Hood Ping Ao | 2013 | Frontiers of Electrical and Electronic Engineering in China2013，8，1： | 4 |
| 14 | Similar Single-Difference Model and Its Algorithm for Solving GPS Monitoring Deformation Directly at Single Epoch显示文摘A new similar single-difference mathematical model (SS-DM) and its corresponding algorithmare advanced to solve the deformationof monitoring point directly in singleepoch. The method for building theSSDM is introduced in detail, and themain error sources affecting the accu-racy of deformation measurement areanalyzed briefly, and the basic algo-rithm and steps of solving the deform-ation are discussed.In order to validate the correctnessand the accuracy of the similar single-difference model, the test with fivedual frequency receivers is carried outon a slideway which moved in plane inFeb. 2001. In the test,five sessions areobserved. The numerical results oftest data show that the advanced mod-el is correct. | YUXuexiang XUShaoquan GAOWei LüWeicai | 2003 | Geo-Spatial Information Science2003，6，4： | 4 |
| 15 | Integrative Multi-Spectral Sensor Device for Far-Infrared and Visible Light Fusion显示文摘红外线、可见的轻图象熔化技术是在最近的年里的多传感器熔化技术的研究的一个热点。存在因为使用二个照相机,红外线、可见的轻熔化技术需要登记在熔化前。然而,登记技术的申请效果还得被改进。因此,一台新奇综合多光谱的传感器设备为红外线、可见的轻熔化被建议,并且由使用横梁 splitter 棱柱,从一样的透镜的同轴的轻事件被投射到红外线的费用联合设备(电荷耦合器件) 和可见轻电荷耦合器件分别地。在这篇论文,建议传感器设备的成像机制与信号获得和熔化的过程被学习。模拟实验,包含眼的系统,信号获得,和信号熔化的全部进程,基于成像效果模型被构造。另外,优秀评估索引被采用分析模拟结果。试验性的结果证明建议传感器设备有效、可行。 | Tiezhu QIAO Lulu CHEN Yusong PANG Gaowei YAN | 2018 | Photonic Sensors2018，8，2： | 3 |
| 16 | Geochemical constraints on the methane seep activity in western slope of the middle Okinawa Trough, the East China Sea显示文摘Anaerobic oxidation of methane and sulfate reduction was studied in the pore waters of four cores at two stations of the middle Okinawa Trough. Pore water vertical distributions of sulfate, methane, sulfide, total alkalinity, ammonium, and phosphate were determined in this study. Our results show strong linear sulfate concentration gradients of 6.83 mmol/L m?1 in Core A and 5.96 mmol/L m?1 in Core C, which were collected from two stations. Concurrent variations of methane, total alkalinity and hydrogen sulfide all exhibit steep increases with depth at both cores, which indicate active methane seep activities around two stations. Pore water ammonium and phosphate concentrations reveal minor influences of organic matter degradation on sulfate reduction at two stations. Sulfate methane interface(SMI) was extrapolated from linear sulfate profiles in methane seep cores. Shallower SMI depths(A: 4.9 mbsf; C: 5.4 mbsf) indicate strong methane fluxes and active anaerobic oxidation of methane in the underlying sediments. | LI Qing CAI Feng LIANG Jie SHAO HeBin DONG Gang WANG Feng YANG ChuanSheng HU GaoWei | 2015 | Science China Earth Sciences2015，58，6： | 3 |
| 17 | Restoring After Central Nervous System Injuries:Neural Mechanisms and Translational Applications of Motor Recovery显示文摘Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are leading causes of long-term disability.It is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated limb.Previous studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote recovery.However,the ability to increase plasticity in the injured brain is restricted and difficult to improve.Therefore,over several decades,researchers have been prompted to enhance the compensation by the unaffected hemisphere.Animal experiments have revealed that regrowth of ipsilateral descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor function.In addition,several clinical treatments have been designed to restore ipsilateral motor control,including brain stimulation,nerve transfer surgery,and brain–computer interface systems.Here,we comprehensively review the neural mechanisms as well as translational applications of ipsilateral motor control upon rehabilitation after CNS injuries. | Zhengrun Gao Zhen Pang Yiming Chen Gaowei Lei Shuai Zhu Guotao Li Yundong Shen Wendong Xu | 2022 | Neuroscience Bulletin2022，38，12： | 3 |
| 18 | Simulation of the Accumulation Process of Biogenic Gas Hydrates in the Shenhu Area of Northern South China Sea显示文摘Objective Previous work has largely discussed the relations between sediment structures and accumulation of gas hydrates in the Shenhu area of South China Sea,but has not documented why the gas hydrates occurred at the seafloor topographic highs.Many gas hydrate exploration examples abroad also indicate that the saturation of | LIAO Jing GONG Jianming Lü Wanjun WU Nengyou YUE Baojing LUAN Xiwu HU Gaowei | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 3 |
| 19 | Cathodic micro-arc electro-deposition of ZrO_2 coatings in an aqueous solution containing colloidal particles显示文摘By a novel technique-cathodic micro-arc electro-deposition(CMED),ZrO2 coatings were deposited on an FeCrAl alloy.Experimental results show that the necessary conditions for obtaining ZrO2 coatings are to apply a pulse peak voltage over a critical value and add moderate amounts of ZrO2 colloidal particles and Zr(NO3)4 in the equeous solution.The as-deposited coatings are porous because hydrogen,water,and other vapors are generated and released from the coatings to the solution during the spark reaction.The coatings contain monoclinic and tetragonal crystalline ZrO with certain degree of amorphous structure.The processing parameters and mechanism of CMED were discussed. | YANGXiaozhan GAOWei 等 | 2002 | Rare Metals2002，21，3： | 2 |
| 20 | Effect of Methane Gas on Acoustic Characteristics of Hydrate-Bearing Sediment–Model Analysis and Experimental Verification显示文摘Gas leakage is an important consideration in natural systems that experience gas hydrate accumulation.A number of velocity models have been created to study hydrate-bearing sediments,including the BGTL theory,the weighted equation,the Wood equation,the K-T equation,and the effective medium theory.In previous work,we regarded water as the pore fluid,which meant its density and bulk modulus values were those of water.This approach ignores the presence of gas,which results in a biased calculation of the pore fluid's bulk modulus and density.To take into account the effect of gas on the elastic wave velocity,it is necessary to recalculate the bulk modulus and density of an equivalent medium.Thus,a high-pressure reactor device for simulating leakage systems was developed to establish the relationship between wave velocity and hydrate saturation in methane-flux mode.A comparison of the values calculated by the velocity model with the experimental data obtained in this study indicates that the effective medium theory(EMT,which considers gas effects)is more applicable than other models.For hydrate saturations of 10%–30%,the result ranges between EMT-B(homogenous gas distribution)and EMT-B(patchy gas distribution).For hydrate saturations of 30%–60%,the results are similar to those of the EMT-B(homogenous gas distribution)mode,whereas hydrate saturations of 60%–70%yield results similar to those of the EMT-A mode.For hydrate saturations greater than 80%,the experimental results are similar to those of the EMT-B mode.These results have significance for hydrate exploitation in the South China Sea. | BU Qingtao HU Gaowei LIU Changling DONG Jie XING Tongju SUN Jianye LI Chengfeng MENG Qingguo | 2021 | Journal of Ocean University of China2021，20，1： | 2 |
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