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您的检索式：作者名="GAO Yangping"
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| 1 | Flight dynamics characteristics of canard rotor/wing aircraft in helicopter flight mode显示文摘The aerodynamic layout of the Canard Rotor/Wing(CRW) aircraft in helicopter flight mode differs significantly from that of conventional helicopters. In order to study the flight dynamics characteristics of CRW aircraft in helicopter mode, first, the aerodynamic model of the main rotor system is established based on the blade element theory and wind tunnel test results. The aerodynamic forces and moments of the canard wing, horizontal tail, vertical tail and fuselage are obtained via theoretical analysis and empirical formula. The flight dynamics model of the CRW aircraft in helicopter mode is developed and validated by flight test data. Next, a method of model trimming using an optimization algorithm is proposed. The flight dynamics characteristics of the CRW are investigated by the method of linearized small perturbations via Simulink. The trim results are consistent with the conventional helicopter characteristics, and the results show that with increasing forward flight speed, the canard wing and horizontal tail can provide considerable lift,which reflects the unique characteristics of the CRW aircraft. Finally, mode analysis is implemented for the linearized CRW in helicopter mode. The results demonstrate that the stability of majority modes increases with increasing flight speed. However, one mode that diverges monotonously,and the reason is that the CRW helicopter mode has a large vertical tail compared to the conventional helicopter. The results of the dynamic analysis provide optimization guidance and reference for the overall design of the CRW aircraft in helicopter mode, and the model developed can be used for control system design. | Honggang GAO Ao HE Zhenghong GAO Yang NA Yangping DENG | 2019 | Chinese Journal of Aeronautics2019，32，7： | 3 |
| 2 | A generalized anisotropic failure criterion for geomaterials显示文摘 | Gao Zhiwei Zhao Jidong Yao Yangping | 2010 | International Journal of Solids and Structures2010，47，31： | 1 |
| 3 | Electroacupuncture stimulating Neixiyan(EX-LE5)and Dubi(ST35)alleviates osteoarthritis in rats induced by anterior cruciate ligament transaction via affecting DNA methylation regulated transcription of miR-146a and miR-140-5p显示文摘OBJECTIVE:To explore whether electroacupuncture(EA could alleviate osteoarthritis(OA)through affecting the DNA methylation regulated transcription of miR-146a and mi R-140-5p.METHODS:Sixty male eight-week-old Sprague-Dawley rats were divided into three groups:normal group(normal healthy rats;no treatment),model group(OA rats;no treatment)and EA group(OA rats treated with EA).Safranin O staining and modified Mankin’s score were performed to evaluate the histopathological alterations and degeneration of cartilage 8 weeks after 8 consecutive weeks of treatment.Quantitative real time polymerase chain reaction(qR T-PCR)assay was employed to evaluate the expression of miR-146a in the cartilage tissue and miR-140-5p in the synovium tissue,respectively.The bisulfite sequencing analysis and quantitative methylation specific PCR(qMSP)were used to analyze the status of methylation in the regulatory regions of miR-146a and miR-140-5p.Chromatin immunoprecipitation(ChIP)assay were performed to assess the binding of nuclear factor-kappa B(NF-κB)and signal transducer and activator of transcription 3(SMAD-3)in the regulatory regions of miR-146a and miR-140-5p.Western blot analysis was performed to detect the expressions of DNA Methyltransferase 1(DMNT1),DNA Methyltransferase 3A(DMNT3A),and DNA Methyltransferase 3A(DMNT3b),NF-κB,SMAD3 levels.RESULTS:Our results showed that EA treatment significantly upregulated miR-146a and miR-140-5p expressions.qMSP analysis showed that EA significantly decreased methylation levels of miR-140-5p regulated region and miR-146a promoter in OA cartilage and synovium.Bisulfite DNA sequencing(BDS)and ChI P analysis showed that EA significantly increased binding affinity of SMAD3 and NF-kB on the hypermethylated miR-140 regulatory region and miR-146a promoter,respectively.Western Blot analysis demonstrated that EA also significantly decreased expressions of methylation related proteins-DMNT1,DMNT3a,and DMNT3b as well as NF-κB and SMAD3.CONCLUSIONS:Electroacupuncture stimulating Neixiyan(EX-LE5)and Dubi(ST35)may alleviate OA via affecting the DNA methylation regulated transcription of miR-146a and miR-140-5p. | DING Luobin WANG Huajun LI Yao LI Jia LI Ling GAO Yangping GUAN Jian GENG Weiqiang | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 0 |
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