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| 1 | Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis显示文摘The nonalcoholic fatty liver disease(NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD encompasses a wide histological spectrum ranging from benign simple steatosis to non-alcoholic steatohepatitis(NASH). Sustained inflammation in the liver is critical in this process. Hepatic macrophages, including liver resident macropaghes(Kupffer cells), monocytes infiltrating the injured liver, as well as specific lymphocytes subsets play a pivotal role in the initiation and perpetuation of the inflammatory response, with a major deleterious impact on the progression of fatty liver to fibrosis. During the last years, Th17 cells have been involved in the development of inflammation not only in liver but also in other organs, such as adipose tissue or lung. Differentiation of a na?ve T cell into a Th17 cell leads to pro-inflammatory cytokine and chemokine production with subsequent myeloid cell recruitment to the inflamed tissue. Th17 response can be mitigated by T regulatory cells that secrete anti-inflammatory cytokines. Both T cell subsets need TGF-β for their differentiation and a characteristic plasticity in their phenotype may render them new therapeutic targets. In this review, we discuss the role of the Th17 pathway in NAFLD progression to NASH and to liver fibrosis analyzing different animal models of liver injury and human studies. | Carla Melisa Chackelevicius Sabrina Eliana Gambaro Claudio Tiribelli Natalia Rosso | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Comparison of PM_(10) concentrations and metal content in three different sites of the Venice Lagoon: An analysis of possible aerosol sources显示文摘The Venice Lagoon is exposed to atmospheric pollutants from industrial activities, thermoelectric power plants, petrochemical plants, incinerator, domestic heating, ship traffic, glass factories and vehicular emissions on the mainland. In 2005, construction began on the mobile dams (MOSE), one dam for each channel connecting the lagoon to the Adriatic Sea as a barrier against high tide. These construction works could represent an additional source of pollutants. PM 10 samples were taken on random days between 2007 and 2010 at three different sites: Punta Sabbioni, Chioggia and Malamocco, located near the respective dam construction worksites. Chemical analyses of V, Cr, Fe, Co, Ni, Cu, Zn, As, Mo, Cd, Sb, Tl and Pb in PM 10 samples were performed by Inductively coupled plasma-quadrupole mass spectrometry (ICP-QMS) and results were used to identify the main aerosol sources. The correlation of measured data with meteorology, and source apportionment, failed to highlight a contribution specifically associated to the emissions of the MOSE construction works. The comparison of the measurements at the three sites showed a substantial homogeneity of metal concentrations in the area. Source apportionment with principal component analysis (PCA) and positive matrix factorization (PMF) showed that a four principal factors model could describe the sources of metals in PM 10 . Three of them were assigned to specific sources in the area and one was characterised as a source of mixed origin (anthropogenic and crustal). A specific anthropogenic source of PM 10 rich in Ni and Cr, active at the Chioggia site, was also identified. | Daniele Contini Franco Belosi Andrea Gambaro Daniela Cesari Angela Maria Stortini Maria Chiara Bove | 2012 | Journal of Environmental Sciences2012，24，11： | 4 |
| 3 | Growth factors and the kidney in diabetes mellitus显示文摘 | Gambaro G Baggio B | 1998 | Crit Rev Clin Lab Sci1998，35，1： | 1 |
| 4 | Seasonal evolution of gas-phase PCB concentrations in the Venice Lagoon area 显示文摘 | Manodori L Gambaro A Moret I | 2006 | Chemosphere2006，62，3： | 1 |
| 5 | The seasonal variations of dimethyl sulphide and carbon disulphide in surface water of the Venice Lagoon显示文摘 | Ivo Moret Andrea Gambaro | 2000 | Marine Chemistry2000，71，： | 1 |
| 6 | Middle distillates from hydrocracking of FT waxes:Composition,characteristics and emission properties 显示文摘 | CALEMMA V GAMBARO C PARKER W O | 2010 | Catalysis Today2010，149，： | 1 |
| 7 | Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease):a Padua Medical School discovery in the 1930s显示文摘 | Gambaro G Feltrin GP Lupo A | | 0，，04： | 1 |
| 8 | Friction stir welding of dissimilar A1 6013-T4 to X5CrNil8-10 stainless steel 显示文摘 | UZUN H DALLE DONNE C ARGAGNOTTO A GHIDINI T GAMBARO C | 2005 | Materials & Design2005，26，： | 1 |
| 9 | Direct determina- tion of levoglucosan at the picogram per milliliter level in Ant- arctic ice by high-performance liquid chromatography/electros- pray ionization triple quadrupole mass spectrometry显示文摘 | Gambaro A Zangrando R Gabrielli P | 2008 | Analyt- ical Chemistry2008，80，5： | 1 |
| 10 | Association studies of genetic polymorphisms and complex disease显示文摘 | Gambaro G Anglani F D'Angelo A | 2000 | Lancet2000，355，： | 1 |
| 11 | Friction stir welding of dissimilar A1 6013-T4 to X5CrNil8-10 stainless steel显示文摘 | UZUN H DONNE C D ARGAGNOTTO A GHIDINI T GAMBARO C | 2005 | Materials and Design2005，26，： | 1 |
| 12 | Treatment with a glyeosaminoglycan formulation ameliorates experimental diabetic nephropathy 显示文摘 | Gambaro G Venturini AP Noonan DM | 1994 | Kidney Int1994，46，： | 1 |
| 13 | Ischemic preconditioning and the risk of acute kidney injury显示文摘 | FERRARO PM GAMBARO G | 2012 | Kidney Int2012，82，2： | 1 |
| 14 | The role of glycosaminoglycans and sulodexide in the treatment of diabetic nephropathy显示文摘 | Abaterosso C Gambaro G | | 0，，： | 1 |
| 15 | Crystals, Randall's plaques and renal stones: do bone and atherosclerosis teach us something? 显示文摘 | GAMBARO G D'ANGELO A FABRIS A | 2004 | J Nephrol2004，17，6： | 1 |
| 16 | Precocious activation of genes of the renin-angiotensin system and the fibrogenic cascade in IgA glomerulonephritis 显示文摘 | Del Prete D Gambaro G Lupo A | 2003 | Kidney Int2003，64，： | 1 |
| 17 | Endoluminal Fundoplication (ELF) for GERD Using EsophyX: a 12-Month Follow-up in a Single-Center Experience显示文摘 | Alessandro Repici Uberto Fumagalli Alberto Malesci Roberta Barbera Camilla Gambaro Riccardo Rosati | 2010 | Journal of Gastrointestinal Surgery2010，，1： | 1 |
| 18 | Glycosaminoglycan therapy prevents TGF-betal over expression and patho- logic changes in renal tissue of long-term diabetic rats 显示文摘 | Ceol G Gambaro G Sauer U | 2000 | J Am Soe Nephrology2000，11，12： | 1 |
| 19 | Precocious activation of genes of the renin-angiotensin system and the fibrogenic cascade in IgA glomerulonephritis显示文摘 | Del Prete D Gambaro G Lupo A | 2003 | Kidney Int2003，64，1： | 1 |
| 20 | Combined treatment with renin-angiotensin system blockers and polyunsaturated fatty acids in proteinuric IgA nephropathy:a randomized controlled trial显示文摘 | Ferraro PM Ferraccioli GF Gambaro G | 2009 | Nephrol Dial Transplant2009，24，： | 1 |
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