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| 1 | Antiplatelet therapy in patients receiving aortic bioprostheses: a report of clinical and instrumental safety显示文摘 | di Marco F Grendene S Feltrin G | 2007 | J Thorac Card iovasc Surg2007，133，6： | 1 |
| 2 | Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease):a Padua Medical School discovery in the 1930s显示文摘 | Gambaro G Feltrin GP Lupo A | | 0，，04： | 1 |
| 3 | 显示文摘 | Caminiti R Feltrin A | 1992 | J Mol Struct1992，257，： | 1 |
| 4 | Antiplatelet therapy in patients receiving aortic bioprostheses:A report of clinical and instrumental safety显示文摘 | Marco F Grendene S Feltrin G | 2007 | J Thorac Cardiovasc Surg2007，133，6： | 1 |
| 5 | Damage identification using modal data: experiences on a prestressed concrete bridge显示文摘 | Huth O Feltrin G Maeck J | 2005 | Journal of Structural Engineering ASCE2005，131，12： | 1 |
| 6 | Fractal analysis of lumbar vertebral cancellous bone architecture显示文摘 | Feltrin GP Macchi V Saccavini C | 2001 | Clin Anat2001，14，6： | 1 |
| 7 | 显示文摘 | Feltrin KL Little TJ Meyer JH | 2004 | Am J Physiol2004，287，： | 1 |
| 8 | Antioxidant activities of flavonol derivative from the lesves and stem bark of scutia buxifolia reiss显示文摘 | Boligon A A Pereira R P Feltrin A C | 2009 | Bioresource Technology2009，100，24： | 1 |
| 9 | Antioxidant activities of flavonol derivatives from the leaves and stem bark of Scutia buxifolia Reiss显示文摘 | Aline Augusti Boligon Romaiana Picada Pereira Andriéli Cassel Feltrin Michel Mansur Machado Vanessa Janovik Jo?o Batista Teixeira Rocha Margareth Linde Athayde | 2009 | Bioresource Technology2009，，24： | 1 |
| 10 | Predictive modelling of prospectivity for Pb-Zn deposits in the Lawn Hill Region, Queensland, Australia显示文摘 | Feltrin L | 2008 | Ore Geology Reviews2008，34，： | 1 |
| 11 | Role of ulnar nerve sonography in leprosy neuropathy with electrophysiologic correlation 显示文摘 | Elias J Jr Nogueira-Barbosa MH Feltrin LT | 2009 | J Ultrasound Med2009，28，9： | 1 |
| 12 | Medullary sponge kidney (Lenarduzzi - Cacchi- Ricci disease ): a Padua Medical School discovery in the 1930s 显示文摘 | Gambaro G Feltrin GP Lupo A | 2006 | Kidney Int2006，69，4： | 1 |
| 13 | Effects of varying combinations of intraduodenal lipid and carbohydrate on antropyloroduodenal motility,hormone release,and appetite in healthy males显示文摘 | Seimon RV Feltrin KL Meyer JH | 2009 | Am J Physiol Regul Integr Comp Physiol2009，296，4： | 1 |
| 14 | Duraplasty with biosynthetic cellulose: an experimental study 显示文摘 | Feltrin L T Fontes P T | 1997 | J Neurosurg1997，86，1： | 1 |
| 15 | Design of viscous dampers targeting multiple cable modes显示文摘 | F. Weber G. Feltrin M. Ma?lanka W. Fobo H. Distl | 2009 | Engineering Structures2009，，11： | 1 |
| 16 | Duraplasty withbiosynthetic cellulose: an experimental study 显示文摘 | Mello LR Feltrin LT Fontes Neto PT | 1997 | J Neurosurg1997，86，1： | 1 |
| 17 | Cycle energy control of magnetorheological dampers on cables显示文摘 | F Weber H Distl G Feltrin M Motavalli | 2009 | Smart Materials and Structures2009，，1： | 1 |
| 18 | Effects of the phases of the menstrual cycle on gastric emptying, glycemia,plasma GLP-1 and insulin, and energy intake in healthy lean women显示文摘 | Brennan IM Feltrin KL Nair NS | 2009 | Am J Physiol Gastrointest Liver Physiol2009，297，3： | 1 |
| 19 | Essential oil composition, antioxidant and antimicrobial activities of Guazzuma Ulmifolia from Brazil 显示文摘 | Aline Augusti Boligon Andrieli Cassel Feltrin Amanda Leitao Gindri | 2013 | Medicinal and Aromatic Plants2013，2，3： | 1 |
| 20 | Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate显示文摘BACKGROUND The epiphyseal growth plate is an important anatomical segment localized on the ends of a long bone.Despite the abovementioned atractive reasons for alendronate’s use,few data on the effect of alendronate during epiphyseal growth exist.AIM Verify the effect of alendronate on the growth epiphyseal plate,and compare its effect with the size of the femur during the double-staining of the immunolocalization of transforming growth factor-β1(TGF-β1)and bone morphogenetic protein-2(BMP2)in endochondral ossifing in specimens that have received alendronate.METHODS Forty newborn rats were randomly divided into two groups:a control group(were given applications of 1 mg/kg physiologic saline)and a group that received Alendronate(a dose of 2.5 mg/kg).These groups were then divided into two subgroups for euthanasia in two and 12 d of life.After euthanasia,the femurs were removed,and the femoral bones were measured linearly between the apex of the greater trochanter until the lower intercondylar midlle face to verify the probable bone growth between 3 and 12 d in control and alednroanto treated rats.Posteriorly,the surgical pieces were also sent to the histopathology laboratory to produce histological slides.The obtained slides were stained with hematoxylin and eosin to measure each of the cartilage zones in endochondral development.and other slides were immunohistochemically tested for anti-TGF-β1 and BMP-2 antibodies to investigate the immunolocalization of these proteins in the epiphyseal plaque area.RESULTS On the third day,some diferences between the control group and specimens treated with alendronate were verified.Macroscopiccaly,we found similarities in size between the femoral bones when we compared the control group with the specimens that received alendronate.On the 12^th day,the bone size of the mice receiving the drug was significantly smaller than those of the control group.These results coincide with changes in the TGF-β1 and BMP-2 expression.In the specimens that received alendronate,the TGF-β1 was expressed in some sites of trabecular bone that was neoformed,peripherally to the bone marrow area.The BMP-2 was also positive in proliferative chondrocytes and hypertrofic chondrocytes.On the 12^th day,all layers of chondrocytes exhibited positivity for BMP-2 in the specimens that received alendronate.In the interface between the trabecular bone and cartilage,an area of disorganized bone deposition was evident.Neoformed bone also appeared to be different at 12 d.In the control group,BMP-2 was positive in an intense area of bone trabeculae,whereas the alendronate-treated group showed TGF-β1 positive trabeculae and a greater bone area.CONCLUSION Alendronate alters the immunolocalization of TGF-β1 and BMP-2 simultaneously,a condition that changes the usual histological aspects of the cartilage zone and impairs epiphysis growth and femur growth. | Juliana Souza Vieira Emanuelle Juliana Cunha Juliana Feltrin de Souza Luis Henrique Koeler Chaves Jessica Lakes de Souza Allan Fernando Giovanini | 2020 | World Journal of Experimental Medicine2020，10，1： | 1 |
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