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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | 肾包膜下种植建立人前列腺癌异种移植动物模型显示文摘目的 采用肾包膜下种植方案建立人前列腺癌异种移植动物模型.方法 15只SCID雄鼠按随机表分组法随机分为3组,每组5只.应用组织重组技术,将人前列腺癌新鲜组织和新出生BALB/c雄鼠精囊间质(SVM)在体外重组,显微外科条件下种植于SCID鼠肾包膜下,4周后观察肿瘤种植率并称重、计算体积.检测血清前列腺特异性抗原(PSA)值.用细胞角蛋白(CK)8/18、波形蛋白(vimentin)单克隆抗体特异标记人前列腺上皮和基质成纤维细胞,用P63单克隆抗体标记上皮基底膜证实其是否为前列腺癌组织.另将人前列腺癌新鲜组织单独种植于SCID鼠肾包膜下作为对照.结果 15只SCID鼠78只次组织种植中无一只死亡.4周后,重组种植组成瘤率为100%(39/39),单独种植组为94.1%(37/39),差异无统计学意义(P>0.05).新生瘤体为实体状、不规则、黄/白色,隆出肾脏表面和(或)嵌入肾实质.重组种植组瘤体生长旺盛,单独种植组瘤体较为平坦,肿瘤大小及重量在两组间差异有统计学意义[(9.7±3.1)mm^3比(6.8±2.0)mm^3;(12.1±3.6)μg比(8.2±2.2)μg,均P<0.01].重组种植组血清PSA值高于单独种植组,但两组间差异无统计学意义(P>0.05).CK8/18、vimentin单抗标记证实新生瘤体为人源性前列腺组织,P63单抗标记显示上皮基底膜消失证实为前列腺癌.结论 肾包膜下种植可高效率建立人前列腺癌异种移植动物模型.本模型含有肿瘤基质成分,可为体内研究前列腺癌发病和病程演变中间质-上皮细胞相互作用提供技术平台. | 孙宏斌 WANG Hong Renea A Taylor Gall P Risbridger | 2010 | 中华医学杂志2010，90，30： | 4 |
| 3 | Real-Time Three-Dimensional Echocardiography: A Novel Technique to Quantify Global Left Ventricular Mechanical Dyssynchrony显示文摘 | S Kapetanakis M T. Kearney A Siva N Gall M Cooklin M J. Monaghan | 2005 | Circulation2005，，7： | 3 |
| 4 | Real-Time Three-Dimensional Echocardiography: A Novel Technique to Quantify Global Left Ventricular Mechanical Dyssynchrony显示文摘 | S Kapetanakis M T. Kearney A Siva N Gall M Cooklin M J. Monaghan | 2005 | Circulation2005，，： | 2 |
| 5 | Design and validation of a microarray for detection, hemagglutinin subtyping, and pathotyping of avian influenza viruses显示文摘 | Gall A Hoffmann B Harder T | 2009 | J Clin Microbiol2009，47，2： | 1 |
| 6 | Oxidized LDL and its compound lysophosphatidylcholine potentiate Ang K- induced vasoconstiction by stimulation of RhoA显示文摘 | Galle J Mameghani A Bolz SS | 2003 | J Am Soc Nephrol2003，14，6： | 1 |
| 7 | Estimating genetic change from selection显示文摘 | GALL G A E BAKAR Y FAMULA T | 1993 | Aquaculture1993，111，： | 1 |
| 8 | Development and worldwide distribution of the Anglo Nubian goat显示文摘 | Stemmer A Marianna S S Gall C | 2009 | Tropical and Subtropical Agroecosystems2009，11，1： | 1 |
| 9 | Vitamin D levels and mor- tality in type 2 diabetes 显示文摘 | Joergensen C Gall MA Schmedes A | 2010 | Diabetes Care2010，33，10： | 1 |
| 10 | The auxili-like phosphoprotein Swa2p is required for clathrin function in yeast显示文摘 | GALL W E HIGGINBOTHAM M A CHEN C Y | 2000 | Curr Biol2000，10，： | 1 |
| 11 | Molecular variation in the nucleoprotein gene(ORF7) of the porcine reproductive and respiratory syndrome virus (PRRSV)显示文摘 | Le Gall A L Legeay O Bourhy H | 1998 | Virus Research1998，54，1： | 1 |
| 12 | New chemotherapeutic strategies in eolorectal caneer显示文摘 | Moehler M Teufel A Galle PR | 2005 | Recent Results Cancer Res2005，165，： | 1 |
| 13 | An Investigation of Relationships between Communication Style and Leader Member Exchange 显示文摘 | Yrle A C Hartman S Galle W P | 2002 | Journal of Communication Management2002，6，1： | 1 |
| 14 | Gas-exchange and chlorophyll fluorescence measure- ments in grapevine leaves in the field显示文摘 | Gall A Flexas J | 2010 | Methodologies and Results in Grapevine Research2010，，： | 1 |
| 15 | Thermal processing of polycrystalline Ni-Ti shape memory alloys 显示文摘 | FRICK C P ORTEGA A M TYBER J MAKSOUND A E M MAIER H J LIU Y N GALL K | 2005 | Materials Science and Engineering A2005，405，12： | 1 |
| 16 | Sequential FDG-PET and induction chemotherapy in locally advanced adenocarcinoma of the Oesophago-gastricjunction (AEG): the Heidelberg Imaging pro-gram in Cancer of the oesophago-gastric junction during Neoadju- rant treatment: HICON trial显示文摘 | Lorenzen S yon Gall C Stange A | 2011 | BMC Cancer2011，11，： | 1 |
| 17 | Glomerular structure and function in proteinuric type 2 ( non - insulin - dependent) dia- betic patients显示文摘 | Osterby R Gall MA Schmitz A | 1993 | Diabetologia1993，36，10： | 1 |
| 18 | Oxidized low-density lipo- protein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKC alpha显示文摘 | Fleming I Mohamed A Galle J | 2005 | Cardiovasc Res2005，65，4： | 1 |
| 19 | Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA显示文摘 | Leslie A Kavanagh D Honeyborne I Pfafferott K Edwards C Pillay T Hilton L Thobakgale C Ramduth D Draenert R Le Gall S Luzzi G Edwards A Brander C Sewell A K Moore S Mullins J Moore C Mallal S Bhardwaj N Yusim K Phillips R Klenerman P Korber B Kiepiela P Walker B Goulder P | 2005 | J Exp Med2005，201，6： | 1 |
| 20 | Purification and characterization of a new K-carrageenase from a marine Cytoph- aga-like bacterium显示文摘 | POTIN P SANSEAU A LE GALL Y | 1991 | Eur J Biochem1991，201，： | 1 |
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