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| 1 | Panax ginseng natural populations: their past, current state and perspectives显示文摘瞄准:人参属人参,遗传和它 Primorye (俄国) 的自然人口的个体发生的结构的交配系统被调查。方法:基因差异用紧密相联的酶和荧光灯地基于的自动化放大碎片长度多型性(AFLP ) 和简单顺序被估计重复(SSR ) 标记。结果:在种类水平的全部的基因差异与紧密相联的酶是低的试金(0.023 ) ,和有 AFLP (0.255 ) 和 SSR (0.259 ) 的高度方法。它根据紧密相联的酶(>99%) 在人口以内被观察, AFLP (>85%) ,和 SSR (>73%) 试金。基因可变性分发的索引指出开拓殖民地在早 Holocene 在温暖的时期期间从南部的避难处由人参的 Sikhote-Alin 种。到异花受粉和自花传粉的人参植物的能力被显示出,人参属人参是容许的单性生殖的植物的假设被证实。人参的繁殖系统拥有授精进程的高粘性和稳定性帮助种类处于压力条件幸存。外部或内部的因素引起的骚乱能由于人参小卵或单性生殖的胚胎开发的形态基因的潜力被减少。因为一些生活阶段是不在的或很少发生,人参人口的生活阶段结构的分析证明所有他们不是完整成分的。结论:在所有 3 张人口,处女和年轻生产个人是占优势的。人口学习了的这个工具是可行的,自然人参人口的再介绍还是可能的。 | Yuri N ZHURAVLEV Olga G KOREN Galina D REUNOVA Tamara I MUZAROK Tatiyana Yu GORPENCHENKO Irina L KATS Yuliya A KHROLENKO | 2008 | Acta Pharmacologica Sinica2008，29，9： | 3 |
| 2 | Linagliptin alleviates fatty liver disease in diabetic db/db mice显示文摘AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independent to changes in the plasma glucose levels. CONCLUSION The DPP4 inhibitor linagliptin alleviates liver steatosis and structural changes in the hepatic microvasculature and lymphatic roots in a model of NAFLD in diabetic db/db mice. | Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov | 2016 | World Journal of Diabetes2016，7，19： | 2 |
| 3 | Structure and Deformational Behavior of Poly(vinylidene fluoride) Hard Elastic Films显示文摘 | Ivan D Viii B Viktor L Galina E | 2007 | Acta chimica slovenica2007，54，： | 1 |
| 4 | Development of a PCR test to diagnose Haemophilus parasuis infections显示文摘 | Oliveira S Galina L Pijoan C | | 0，，06： | 1 |
| 5 | Charac-terisation of a resource population of pigs screened for resis-tance to salmonellosis显示文摘 | P.M. van Diemen M B Kreukniet L Galina | | 0，，： | 1 |
| 6 | Genetic polymorphisms in the paraoxonase 1 gene and risk of ovarian epithelial carcinoma 显示文摘 | Galina L Wilkens LR Pamela J | 2008 | Cancer Epldem Biomar2008，17，8： | 1 |
| 7 | Development of a PCR test to diagnose Haemophilus parasuis in fections 显示文摘 | OLIVEIRA S GALINA L PIJOAN C | 2001 | Vet Di- agn Invest2001，13，6： | 1 |
| 8 | Naturally - farrowed, artificially - reared pigs as an alternative model forexperimental infection by Haemophilus parasuis显示文摘 | Oliveira S Galina L Blanco I | 2003 | Can J Vet Res2003，67，2： | 1 |
| 9 | Naturally-farrowed,artifi-cially-reared pigs as an alternative model for experimental infec-tion by Haemophilus parasuis显示文摘 | Oliveira S Galina L Blanco I | 2003 | Can J Vet Res2003，67，2： | 1 |
| 10 | Surface chemical modification of microfibrillated cellulose:improvement of barrier properties for packaging applications显示文摘 | Galina R Marianne L | | 0，，01： | 1 |
| 11 | Interaction between Streptococ-cus suis serotype 2 and porcine reproductive and respiratorysyndrome virus in specific pathogen-free piglets显示文摘 | Galina L Pijoan C Sitjar M | 1999 | The Veteri-nary Rrcord1999，134，3： | 1 |
| 12 | Development of a PCR test to diagnose Haemophilus parasuis infections 显示文摘 | OLIVEIRA S GALINA L PIJOAN C | 2001 | J Vet Diagn In- vest2001，13，6： | 1 |
| 13 | Highly efficient transient expression of functional recombinant antibodies in lettuce 显示文摘 | VALENTINE N GALINA E HYUNG-il L | 2005 | Plant Science2005，169，： | 1 |
| 14 | Development of a PCR test to diag nose Haemophilus parasuis infections显示文摘 | Oliveira S Galina L Pijoan C | 2001 | J Vet Diagn Invest2001，13，6： | 1 |
| 15 | Development of a PCR test to diagnose Haemophilus parasuis infections显示文摘 | Oliveira S Galina L Pijoan C | 2001 | J Vet Diagn Invest2001，13，6： | 1 |
| 16 | Comparison be- tween Haemophilus parasuis infection in colostrums- deprived and sow-reared piglets显示文摘 | Blanco I Galina P L Oliveira S | 2004 | Vet Mierobiol2004，103，12： | 1 |
| 17 | Development of a PCR test to diagnose Haernophilus parasuis infec- tions显示文摘 | Oliveira S Galina L and Pijoan C | 2001 | J Vet Diagnostic Invest2001，13，6： | 1 |
| 18 | Development of a PCR test to diagnose Haemophilus parasuls infections显示文摘 | Oliveira S Galina L Pijoan C | 2001 | Vet Diagn Invest2001，13，6： | 1 |
| 19 | Development of a PCR test to diag- aose Haemophilus parasuis infections显示文摘 | Oliveira S Galina L Pijoan C | 2001 | J Vet Diagn Invest2001，13，6： | 1 |
| 20 | Naturally-farrowed,artificial-ly-reared pigs as an alternative model for experimentalinfection by Haemophilus parasuis显示文摘 | Oliveira S Galina L Blanco I etal | 2003 | Can J Vet Res2003，67，2： | 1 |
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