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| 1 | Clinical importance of aspirin and clopidogrel resistance显示文摘Aspirin and clopidogrel are important components of medical therapy for patients with acute coronary syndromes, for those who received coronary artery stents and in the secondary prevention of ischaemic stroke. Despite their use, a significant number of patients experience recurrent adverse ischaemic events. Interindividual variability of platelet aggregation in response to these antiplatelet agents may be an explanation for some of these recurrent events, and small trials have linked 'aspirin and/or clopidogrel resistance', as measured by platelet function tests, to adverse events. We systematically reviewed all available evidence on the prevalence of aspirin/clopidogrel resistance, their possible risk factors and their association with clinical outcomes. We also identified articles showing possible treatments. After analyzing the data on different laboratory methods, we found that aspirin/clopidogrel resistance seems to be associated with poor clinical outcomes and there is currently no standardized or widely accepted definition of clopidogrel resistance. Therefore, we conclude that specific treatment recommendations are not established for patients who exhibit high platelet reactivity during aspirin/clopidogrel therapy or who have poor platelet inhibition by clopidogrel. | Gergely Feher Andrea Feher Gabriella Pusch Katalin Koltai Antal Tibold Beata Gasztonyi Elod Papp Laszlo Szapary Gabor Kesmarky Kalman Toth | 2010 | World Journal of Cardiology2010，2，7： | 36 |
| 2 | Comments on “The severity of non-alcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota”显示文摘Non-alcoholic fatty liver disease(NAFLD)has a rising prevalence worldwide.It is characterized with lipid deposition in hepatocytes that is unrelated to alcohol consumption.Insulin resistance and oxidative damage plays a key role in its pathogenesis.[1]NAFLD is a complex disease,classified in simple steatosis(SS)and non-alcoholic steatohepatitis(NASH).Lifestyle changes and treatment of hyperinsulinaemia could reverse SS.However,20-30%of NAFLD patients develop to NASH,which could lead to liver fibrosis,cirrhosis and cancer.[2] | Anna Egresi Krisztina Hagymási Gabriella Lengyel | 2016 | Hepatoma Research2016，2，1： | 29 |
| 3 | EFFECTS OF ACUPUNCTURE ON IMMUNE RESPONSE RELATED TO OPIOID-LIKE PEPTIDES显示文摘Experimental research has recently shown that acupuncture induces the formation of opioid-like peptides (OLPs) in animals. In order to provide further evidence, we tested the β-endorphin levels and other parameters (VIP, lymphocyte subsets, NK cells and monocyte phagocytosis) in a group of 90 patients suffering from various painful disorders treated with acupuncture. Zusanli (St 36) and Hegu (LI 4) acupoints were selected. A homogeneous group of 30 subjects was used as control. Evaluation of the above parameters was made with 3 series of blood tests before treatment, 30 minutes and 24 hours after acupuncture treatment. In the acupuncture group, the following results were achieved: 1) A considerable increase in β-endorphin levels remained high even 24 hours after acupuncture treatment. In addition, we demonstrated an inverted correlation between β-endorphins and VIP; 2) 30 minutes after acupuncture session, 80% of the treated patients showed a significant increase of CD3 and CD4 values and an increase of CD8 24 hours after stimulation; 3) Monocyte phagocytosis was increased in 45% of the treated subjects 30 minutes from starting treatment, and in 100% of them after 24 hours. The percentage of NK cells was also increased in 40% of cases after 30 minutes, and in 50% after 24 hours. However, in the control group, no such significant changes in immune parameters were found. | FILOMENA PETTI ALFIO BANGRAZI ALDO LIGUORI GABRIELLA REALE FLORA IPPOLITI | 1998 | Journal of Traditional Chinese Medicine1998，18，1： | 20 |
| 4 | 葛根素、齐墩果酸及其配伍对T2DM大鼠氧化应激和炎症反应的影响显示文摘目的:观察葛根素、齐墩果酸及其配伍对2型糖尿病大鼠血糖、血脂、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、糖基化终末产物(AGEs)、超敏C反应蛋白(hs-CRP)及胰腺病理组织学的影响。方法:以高糖、高脂饮食联合链脲佐菌素(30 mg.kg-1)ip法建立2型糖尿病大鼠模型,随机分为模型(M)组、二甲双胍(D)组(100 mg.kg-1.d-1)、葛根素(P)组(30 mg.kg-1.d-1)、齐墩果酸(OA)组(10 mg.kg-1.d-1)、葛根素+齐墩果酸(POA)组(40 mg.kg-1.d-1),同期设正常对照组(K)。各治疗组分别ig给予相应药物治疗。治疗前及治疗2,4,6周分别测定各组大鼠空腹血糖(FBG)及餐后2 h血糖(P2hPG),并于给药6周后,测定大鼠总胆固醇(CHOL)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),hs-CRP,血清SOD,MDA,AGEs水平,光镜下观察胰腺病理组织学变化。结果:M组大鼠FBG,P2hPG,CHOL,TG,LDL-C,hs-CRP,MDA,AGEs较K组升高,HDL-C和血清SOD水平明显下降,有统计学差异,对胰腺胰岛细胞有一定损伤。各治疗组大鼠FBG,P2hPG,CHOL,TG,LDL-C,hs-CRP,MDA,AGEs较M组降低,HDL-C和血清SOD水平增加,对胰腺胰岛细胞损伤有不同程度改善。POA组LDL-C水平较P组、OA组降低明显(P<0.05),对胰腺胰岛细胞损伤明显改善。结论:葛根素、齐墩果酸及其配伍可改善实验性2型糖尿病大鼠的糖、脂代谢,其作用机制可能与抗氧化、抑制炎症反应有关。其中葛根素配伍齐墩果酸在降低LDL-C水平、改善胰岛细胞结构方面优于单纯葛根素、齐墩果酸。 | 王会敏 田炜 喇孝瑾 高秀娟 韩婷 王亚 田震亚 Hegyi Gabriella 陈震 李继安 | 2013 | 中国实验方剂学杂志2013，19，15： | 20 |
| 5 | Genomic and genetic alterations influence the progression of gastric cancer显示文摘Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity (LOH), microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric cancer.In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma. | Stefania Nobili Lorenzo Bruno Ida Landini Cristina Napoli Paolo Bechi Francesco Tonelli Carlos A Rubio Enrico Mini Gabriella Nesi | 2011 | World Journal of Gastroenterology2011，17，3： | 17 |
| 6 | 芙蓉统和排碧阶底界全球层型剖面的牙形刺生物地层显示文摘寒武系芙蓉统和排碧阶全球层型剖面——湖南花垣排碧剖面底界界线层的牙形刺生物地层,由下至上划分为Westergaardodina tetragonia带、Westergaardodina matsushitai带和Westergaardodina bicuspidate 3个牙形刺带,可与该界线层的三叶虫带进行很好对比;同时讨论了芙蓉统和排碧阶底界划在牙形刺Westergaardodina mat-sushitai带和Westergaardodina bicuspidata带之间的合理性;此外,还将该牙形刺分带与华北和东北地区寒武系牙形刺带进行了对比。 | 祁玉平 王志浩 Gabriella Bagnoli | 2004 | 地层学杂志2004，28，2： | 16 |
| 7 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 8 | Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives显示文摘Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice. | Roberta Gaziano Gabriella Moroni Cristina Buè Martino Tony Miele Paola Sinibaldi-Vallebona Francesca Pica | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 11 |
| 9 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 10 | From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting显示文摘Fecal calprotectin(FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases(IBD). Many different methods of assessment have been developed and different cutoffs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome(IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD. In IBD patients a correlation with both mucosal healing and histology was found, and there is increasing evidence that FC assessment can be helpful in monitoring disease activity and response to therapy as well as in predicting relapse, post-operative recurrence or pouchitis. Recently, its use in the context of a treat-to-target approach led to a better outcome than clinically-based therapy adjustment in patients with early Crohn's disease. In conclusion, FC measurement represents a cheap, safe and reliable test, easy to perform and with a good reproducibility. The main concerns are still related to the choice of the optimal cut-off, both for differentiating IBD from IBS, and for the management of IBD patients. | Maria Gloria Mumolo Lorenzo Bertani Linda Ceccarelli Gabriella Laino Giorgia Di Fluri Eleonora Albano Gherardo Tapete Francesco Costa | 2018 | World Journal of Gastroenterology2018，24，33： | 8 |
| 11 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 12 | Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion显示文摘瞄准:为了决定是否增加了,并且详细描述对在老鼠模型上在肝的外科期间测量抗氧化剂防卫合适的方法,肝的血流能引起氧化应力和 hepatocyte 损坏。方法:在戊巴比妥钠昏迷状态,侧面的左和肝的中间的脑叶被抓紧让 45 min 让全部的血供给通过另外的脑叶流动。全部的抗氧化剂地位,谷胱甘肽过氧化物酶和超级氧化物 dysmutase 活动,以及 diene 的集中结合,免费 sulphydril 组织,捐赠 H 能力和肝样品的减少的力量被决定。肝的 Chemiluminescent 紧张也被测量。金属离子(艾尔, Ca, Cu, Fe, Mg, Mn, Zn ) 并且肝的 P 和 S 集中与诱导地联合的血浆被决定光排放分光计和 Se 内容被阴极的的脱衣的 voltammetry 测量。结果:谷胱甘肽过氧化物酶和肝的超级氧化物 dysmutase 活动与在假冒的操作的组观察的那些相比在充血组显著地减少了。全部的抗氧化剂地位的水平在充血组也是显著地更低的。捐赠 H 能力,减少的力量和免费 sulphydril 组集中显示出一样的趋势。重要关联(P<0.05 ) 在非特定的抗氧化剂活动在变化之间被发现。这指向了抗氧化剂防卫系统的同时的活动。当 Ca, Fe, Mg, Se 和 P 离子的层次在充血期间是更高的时,艾尔, Cu, Mn, Zn,和 S 比在假冒的操作的组在充血组是更低的。结论:氧化应力在 ischaemia-reperfusion 期间是为未经触动的肝脑叶的损害的主要因素之一。 | LászlóVáli Gabriella Taba KláraSzentmihályi HedvigFébel TímeaKurucz Zsolt Pallai PéterKupcsulik AnnaBlázovics | 2006 | World Journal of Gastroenterology2006，12，7： | 6 |
| 13 | 通莲汤对胃癌MGC803细胞周期及NF-κBs信号通路的影响显示文摘目的:研究通莲汤对胃癌MGC803细胞形态、生长周期的调节作用及细胞核转录因子κB(NF-κB)信号通路的影响,以探讨该方抑制胃癌细胞增殖的机制.方法:将MGC803细胞以1×104个细胞/孔的密度接种于96孔细胞培养板,以含5%胎牛血清DMEM培养液培养,37℃,5%饱和湿度的CO2培养箱孵育,细胞贴壁24 h,分别加入浓度为25~800 mg·L-倍比梯度的通莲汤提取液,以10 ~ 160 mg·L-1倍比浓度的氟脲嘧啶为阳性对照组,孵育48 h后,倒置显微镜下观察细胞形态,MTT比色法检测细胞增殖变化,曲线拟合法计算通莲汤和氟脲嘧啶50%抑制浓度(IC50);以两者48 h IC50浓度处理细胞48 h,流式细胞技术(FCM)测定细胞周期,Western blot法测定细胞IκB激酶β(IKKβ),NF-κB,phosph-NF-κB蛋白水平.结果:通莲汤和氟脲嘧啶48 h IC50值分别为192.74 mg.L-1,23.61 mg·L-1;与空白对照组相比,通莲汤显著影响MGC803细胞周期中G2期,氟脲嘧啶显著影响MGC803细胞周期中G1期(P<0.05);通莲汤和氟脲嘧啶均能显著抑制IKKβ与NF-κB的蛋白表达.结论:通莲汤抑制MGC803细胞生长与抑制细胞于G2期,下调NF-κB通路中IKKβ,NF-κB蛋白的表达有关. | 王亚 贾永森 喇孝瑾 田炜 韩炳生 李继安 郝小惠 Hegyi Gabriella | 2013 | 中国实验方剂学杂志2013，19，22： | 6 |
| 14 | 啤酒麦汁的糖组成及啤酒酵母糖代谢的特征显示文摘麦汁中可发酵性糖包括果糖、葡萄糖、蔗糖、麦芽糖以及麦芽三糖,啤酒发酵过程中酵母对5种可发酵性糖进行吸收代谢,最终生成酒精和CO2。本试验测定了麦汁浸出物中5种糖的含量,并对发酵过程中糖的变化进行了跟踪,通过对糖的吸收机理进行分析,提出了快速发酵酵母的选育策略,可供啤酒快速发酵参考。 | 李红 Gabriella Farkas Kun Szilard 王君伟 闫素娟 金玮鋆 褚洁洁 | 2015 | 酿酒科技2015，，6： | 6 |
| 15 | 代平颗粒对2型糖尿病大鼠血糖、血脂水平及骨骼肌Glut4 mRNA,IRS-1 mRNA表达的影响显示文摘目的:观察中药代平颗粒对2型糖尿病大鼠骨骼肌葡萄糖转运蛋白4(Glut4)、胰岛素受体底物1(IRS-1)基因表达的影响,初步探讨其降低血糖的分子机制。方法:雄性SD大鼠分为正常对照组(8只,普通饲料),其余大鼠采用高脂饲料喂养联合链脲佐菌素(STZ)尾静脉注射的方法造成2型糖尿病成膜大鼠(32只),分为模型组(M)、二甲双胍组(Met)、代平颗粒低剂量组(DL),代平颗粒高剂量组(DH),每组8只。经药物干预4周后检测各组大鼠空腹血糖(FBG)、血脂、空腹胰岛素(FINS)并计算胰岛素敏感指数(ISI),采用实时荧光定量PCR技术检测大鼠骨骼肌Glut4 mRNA,IRS-1 mRNA表达水平。结果:给药后4周,与M组FBG:(20.55±5.50)mmol·L-1,ISI:(-6.05±0.29)比较,Met组FBG(14.75±3.90)mmol·L-1和DH组FBG(11.21±2.95)mmol·L-1均显著下降(P<0.01),Met组ISI(-5.37±0.38)和DH组ISI(-5.38±0.37)均显著升高(P<0.01);M组Glut4 mRNA(0.63±0.13)和IRS-1 mRNA(0.68±0.17)表达量分别为N组的63.3%,67.8%(P<0.01);与M组比较,Met组Glut4 mRNA(0.95±0.19)表达量升高了31%(P<0.01),IRS-1 mRNA(0.88±0.24)表达量无显著升高,DH组Glut4 mRNA(1.19±0.15)和IRS-1 mRNA(1.24±0.22)表达量,分别升高了88.9%,82.4%(P<0.01)。结论:代平颗粒具有降低2型糖尿病大鼠FBG效果,其作用机制之一与增加组织胰岛素敏感性,上调2型糖尿病大鼠骨骼肌中Glut4 mRNA和IRS-1 mRNA的表达,促进骨骼肌对葡萄糖的摄取和利用有关。 | 张艳萍 郭志义 吴范武 Hegyi Gabriella 刘志霞 高秀娟 喇孝谨 柳月娟 崔鹏 李继安 | 2012 | 中国实验方剂学杂志2012，18，13： | 6 |
| 16 | Management of cholelithiasis in Italian children:A national multicenter study显示文摘AIM:To evaluate the management of Italian children with cholelithiasis observed at Pediatric and Surgical Departments linked to Italian Society of Pediatric Gastroenterology Hepatology and Nutrition. METHODS: One-hundred-eighty children (90 males, median age at diagnosis 7.3 years; range, 0-18 years) with echographic evidence of cholelithiasis were enrolled in the study; the data were collected by an anonymous questionnaire sent to participating centers. RESULTS: One hundred seventeen patients were treated with ursodeoxycholic acid; in 8 children dissolution of gallstones was observed, but the cholelithiasis recurred in 3 of them. Sixty-five percent of symptomatic children treated became asymptomatic. Sixty-four patients were treated with cholecystectomy and in only 2 cases a postoperative complication was reported. Thirty- four children received no treatment and were followed with clinical and echographic controls; in no case thedevelopment of complications was reported. CONCLUSION: The therapeutic strategies were extremely heterogeneous. Ursodeoxycholic acid was ineffective in dissolution of gallstones but it had a positive effect on the symptoms. Laparoscopic cholecystectomy was confirmed to be an efficacy and safe treatment for pediatric gallstones. | Claudia Della Corte Diego Falchetti Gabriella Nebbia Marisa Calacoci Maria Pastore Ruggiero Francavilla Matilde Marcellini Pietro Vajro Raffaele Iorio | 2008 | World Journal of Gastroenterology2008，14，9： | 6 |
| 17 | 消除葡萄糖效应提高酵母降糖速度的研究显示文摘葡萄糖阻遏效应是造成啤酒发酵缓慢的原因之一,利用葡萄糖结构类似物可以筛选出抗葡萄糖阻遏效应的菌株,从而提高酵母的发酵速度,常见的葡萄糖结构类似物有2-脱氧-D-葡萄糖和N-乙酰基-D-葡糖胺。本试验以降糖速度为发酵速度指标,利用固体培养以及液体发酵的方法来选择合适的葡萄糖结构类似物,并用紫外诱变法筛选出降糖速度快的突变菌株28号,通过遗传稳定性试验研究了所选菌株的稳定性。 | 李红 Gabriella Farkas Kun Szilard 褚洁洁 闫素娟 金玮鋆 | 2015 | 酿酒科技2015，，7： | 6 |
| 18 | Carbon-Isotope Excursions Recorded in the Cambrian System,South China:Implications for Mass Extinctions and Sea-Level Fluctuations显示文摘Cambrian carbonates with abundant fossils of agnostoid trilobites deposited on the southern slope(Jiangnan slope belt) of the Yangtze Platform and in the Jiangnan deepwater basin are well exposed in the Wangcun Section of western Hunan, South China, and in the Duibian A Section of western Zhejiang, southeastern China, respectively. To better understand the response of carbon-isotope excursions to depositional environment changes, mass extinctions and eustatic events, we collected 530 carbonate samples in fresh roadcut exposures of the two measured sections for analysis of carbon and oxygen isotopic compositions. Data of δ13 C from the Wangcun Section, western Hunan, South China, demonstrate that the Cambrian carbon-isotope profile includes three remarkable positive excursions CPEwc-1, 2, 3 in the Upper Series 2, in the Lower and in the Middle Furongian Series. Three distinctive negative excursions CNEwc-1, 2, 3 were separately tested in the Lower Terreneuvian Series, Lower Series 3 and in the Upper Furongian Series. Similarly, in the corresponding horizons in the Duibian A Section, Zhejiang Province, southeastern China, three positive excursions CPEdb-1, 2, 3 and three negative excursions CNEdb-1, 2, 3 also have been discovered. We interpret these significant carbon-isotope excursions as being associated with enhanced biogenic productivity, mass extinctions and eustatic events. | Jingxun Zuo Shanchi Peng Yuping Qi Xuejian Zhu Gabriella Bagnoli Huaibin Fang | 2018 | Journal of Earth Science2018，29，3： | 6 |
| 19 | Endoscopic mucosal resection for high-grade dysplasia and intramucosal carcinoma in Barrett's esophagus: An Italian experience显示文摘AIM: To evaluate endoscopic mucosal resection (EMR)in patients with high-grade dysplasia (HGD) and/or intramucosal cancer (IMC) in Barrett's esophagus (BE).METHODS: Between June 2000 and December 2003,39 consecutive patients with HGD (35) and/or IMC (4)underwent EMR. BE >30 mm was present in 27 patients.In three patients with short segment BE (25.0%), HGDwas detected in a normal appearing BE. Lesions had a mean diameter of 14.8±10.3 mm. Mucosal resection was carried out using the cap method.RESULTS: The average size of resections was 19.7±9.4×14.6±8.2 mm. Histopathologic assessment postresection revealed 5 low-grade dysplasia (LGD) (12.8%),27 HGD (69.2%), 2 IMC (5.1%), and 5 SMC (-12.8%).EMR changed the pre-treatment diagnosis in 10 patients (25.6%). Three patients with SMC underwehtsurgery.Histology of the surgical specimen revealed 1 T0N0 and 2 T1N0 lesions. The remaining two patients were cancer free at 32.5 and 45.6 mo, respectively. A metachronous lesion was detected after 25 mo in one patient with HGD. Intra-procedural bleeding, controlled at endoscopy,occurred in four patients (10.3%). After a median followup of 34.9 mo, all patients remained in remission.CONCLUSION: In the medium term, EMR is effective and safe to treat HGD and/or IMC within BE and is a valuable staging method. It could become an alternative to surgery. | Massimo Conio Alessandro Repici Renzo Cestari Sabrina Blanchi Gabriella Lapertosa Guido Missale Domenico Della Casa Vincenzo Villanacci Pier Gigi Calandri Rosangela Filiberti | 2005 | World Journal of Gastroenterology2005，11，42： | 6 |
| 20 | Right ventricular septal pacing: Safety and efficacy in a long term follow up显示文摘AIM: To evaluate the safety and efficacy of the permanent high interventricular septal pacing in a long term follow up, as alternative to right ventricular apical pacing. METHODS: We retrospectively evaluated:(1) 244 patients(74 ± 8 years; 169 men, 75 women) implanted with a single(132 pts) or dual chamber(112 pts) pacemaker(PM) with ventricular screw-in lead placed at the right ventricular high septal parahisian site(SEPTAL pacing);(2) 22 patients with permanent pacemaker and low percentage of pacing(< 20%)(NO pacing);(3) 33 patients with high percentage(> 80%) right ventricular apical pacing(RVA). All patients had a narrow spontaneous QRS(101 ± 14 ms). We evaluated New York Heart Association(NYHA) class, quality of life(Qo L), 6 min walking test(6MWT) and left ventricular function(end-diastolic volume, LV-EDV; end-systolic volume, LVESV; ejection fraction, LV-EF) with 2D-echocardiography. RESULTS: Pacing parameters were stable duringfollow up(21 mo/patient). In SEPTAL pacing group we observed an improvement in NYHA class, Qo L score and 6MWT. While LV-EDV didn't significantly increase(104 ± 40 m L vs 100 ± 37 m L; P = 0.35), LV-ESV slightly increased(55 ± 31 m L vs 49 ± 27 m L; P = 0.05) and LV-EF slightly decreased(49% ± 11% vs 53% ± 11%; P = 0.001) but never falling < 45%. In the RVA pacing control group we observed a worsening of NYHA class and an important reduction of LV-EF(from 56% ± 6% to 43% ± 9%, P < 0.0001).CONCLUSION: Right ventricular permanent high septal pacing is safe and effective in a long term follow up evaluation; it could be a good alternative to the conventional RVA pacing in order to avoid its deleterious effects. | Eraldo Occhetta Gianluca Quirino Lara Baduena Rosaria Nappo Chiara Cavallino Emanuela Facchini Paolo Pistelli Andrea Magnani Miriam Bortnik Gabriella Francalacci Gabriele Dell’Era Laura Plebani Paolo Marino | 2015 | World Journal of Cardiology2015，7，8： | 5 |
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