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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Photocatalysed degradation of cyromazine in aqueous titanium dioxide suspensions : comparison with photolysis 显示文摘 | Gortailler G Valette J C Guillard C | 2001 | Journal of Photochemistry and Photobiology A : Chemistry2001，141，1： | 1 |
| 3 | Hypocholesterolaemic effect of fenugreek seeds in dogs 显示文摘 | Valette G Sauvaire Y Baccou JC | 1984 | Atherosderosis1984，50，： | 1 |
| 4 | Not Available显示文摘 | Cabanis C MM Janot G Valette | 1969 | Rev Hist Pharm (Paris)1969，19，： | 1 |
| 5 | Spectral-element analysis in Seismology显示文摘 | Chaljub E Komatitsch D VilotteJ P Capdeville y Valette B Festa G | 2007 | Advances in Geophysics2007，48，： | 1 |
| 6 | Photocatalysed degradation of cyromazine in aqueous titanium dioxide suspensions:comparison with photolysis显示文摘 | GOUTAILLER AU G VALETTE J C GUILLARD C | 2001 | Journal of Photochemistry and Photobiology A:Chemistry2001，141，1： | 1 |
| 7 | Hyperbaslc Media: Metalation of Ketimines; A Fast Convenient Synthesisof 1, 4- Diketones显示文摘 | Larcheveque M Valette G Cuvigny T | 1975 | Synthesis1975，，： | 1 |
| 8 | SSR126768A(4-chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxyben-zyl)-3--methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]--N-ethyl-N-(3-pyridylmethyl)-benzamide,hydrochloride):a new selective and orally active oxytocin receptor antagonist for the prevention of preterm显示文摘 | Serradeil-Le Gal C Valette G Foulon L | | 0，，1： | 1 |
| 9 | Conversion of phenol-based tars over olivine and sand in a biomass gasification atmosphere显示文摘 | NITSCH X COMMANDRE J M CLAVEL P MARTIN E VALETTE J VOLLE G | 2013 | Energy Fuels2013，27，9： | 1 |
| 10 | Hypocholesterolaemic effect of fenugreek seeds in dogs 显示文摘 | Valette G Sauvaire Y Baccou JC | 1984 | Atherosderosis1984，50，： | 1 |
| 11 | Application of data mining techniques for automat settings in emergency control at Hydro-Quebec显示文摘 | Huang J A Vanier G Valette A | 2003 | IEEE Power Engineering Society General Meeting2003，，4： | 1 |
| 12 | Seasonal variation in surface-subsurface water exchange and lateral hyporheic area of two stream-aquifer systems显示文摘 | WROBLICKY G J CAMPANA M E VALETT H M | | 0，，03： | 1 |
| 13 | Loss of OPAl perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis 显示文摘 | Olichon A Baricault L Gas N Guillou E Valette A Belenguer P and Lenacrs G | 2003 | J Biol Chem2003，278，： | 1 |
| 14 | Photoeatalysed Degradation of Cyromazine in Aqueous Titanium Dioxide Suspensions: Comparison with Photolysis显示文摘 | GORTAILLER G VALETTE J C GUILLARD C | 2001 | Journal of Photochemistry and Photobiology A: Chemistry2001，141，1： | 1 |
| 15 | Photocatalysed degradation of cyromazine in aqueous titanium dioxide suspensions: comparison with photolysis显示文摘 | GOUTAILLER G VALETTE J C GUILLARD C | | 0，，： | 1 |
| 16 | Seasonal variation in surface - subsurface water exchange and lateral hyporheic area of two stream-aquifer systems显示文摘 | Wroblicky G J Campana M E Valett H M | 1998 | Water Resources Research1998，34，3： | 1 |
| 17 | Photocatalysed degradation of cyromazine in aqueous titanium dioxide suspensions: comparison with photolysis 显示文摘 | GOUTAILLER G VALETTE J C GUILLARD C | 2001 | J Photochem Photobiol A : Chem2001，141，1： | 1 |
| 18 | Photocatalysed degradation of cyromazine in aqueous titanium dioxide suspensions:comparison with photolysis显示文摘 | Goutailler G Valette J C Guillard C | 2001 | J Photochem Photobiol A:Chem2001，141，1： | 1 |
| 19 | Photocatalysed degradation of cyromazine in aqueous titanium dioxide suspensions:comparison with photolysis显示文摘 | AU Goutailer G Valette J C Guillard C | 2001 | J Photochem photobiol A-Chem2001，141，1： | 1 |
| 20 | Hypocholesterolaemic effect of fenugreek seeds in dogs显示文摘 | Sauvaire Y Baccou JC | 1984 | Atherosderosis1984，50，： | 1 |
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