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| 1 | Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer显示文摘 | Yuji Maehata Shotaro Nakamura Kiyoshi Fujisawa Motohiro Esaki Tomohiko Moriyama Kouichi Asano Yuta Fuyuno Kan Yamaguchi Issei Egashira Hyonji Kim Motonobu Kanda Minako Hirahashi Takayuki Matsumoto | 2012 | Gastrointestinal Endoscopy2012，，1： | 10 |
| 2 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 3 | Genetic analysis is helpful for the diagnosis of small bowel ulceration显示文摘The widespread use of capsule endoscopy and balloonassisted endoscopy has provided easy access for detailed mucosal assessment of the small intestine. However, the diagnosis of rare small bowel diseases, such as cryptogenic multifocal ulcerous stenosing enteritis(CMUSE), remains difficult because clinical and morphological features of these diseases are obscure even for gastroenterologists. In an issue of this journal in 2017, Hwang et al reviewed and summarized clinical and radiographic features of 20 patients with an established diagnosis of CMUSE. Recently, recessive mutations in the PLA2G4A and SLCO2A1 genes have been shown to cause small intestinal diseases. The small bowel ulcers in each disease mimic those in the other and furthermore those found in nonsteroidal anti-inflammatory drug-induced enteropathy. These recent and novel findings suggest that a clinical diagnosis exclusively based on the characteristics of small bowel lesions is possibly imprecise. Genetic analyses seem to be inevitable for the diagnosis of rare small bowel disorders such as CMUSE. | Junji Umeno Takayuki Matsumoto Atsushi Hirano Yuta Fuyuno Motohiro Esaki | 2018 | World Journal of Gastroenterology2018，24，28： | 2 |
| 4 | Respiratory muscle strength after hung resection with special reference to age procedures of thoracotomy显示文摘 | Nomori H Horio H Fuyuno G | 1996 | Eur J Cardiothorac Surg1996，10，： | 1 |
| 5 | Preoperative respiratory muscle training:assessment in thoracic surgery patient with special reference to postoperative pulmonary complications显示文摘 | Nomori H Kobayashi R Fuyuno G | 1994 | Chest1994，105，6： | 1 |
| 6 | Preoperative respiratory muscle training: assessment in thoracic surgery pa- tients with special reference to postoperative pulmonary com- plications 显示文摘 | Nomori H Kobayashi R Fuyuno G | 1994 | Chest1994，105，： | 1 |
| 7 | Contacting metastasis of a fibrous tumor of the pleura显示文摘 | Nomori H Horio H Fuyuno G | 1997 | Eur J Cardiothorac Surg1997，12，6： | 1 |
| 8 | Cash for papers : putting a premium on publication 显示文摘 | Fuyuno I | 2006 | Nature2006，，7095： | 1 |
| 9 | Intrapulmonary hematoma surrounding the stapled line after video-assisted thoracoscopic bullectomy for spontaneous pneumotharax显示文摘 | Horioh Nomori H Fuyuno G | 1999 | Kyobu Geka1999，52，6： | 1 |
| 10 | Protein 1 Clara cell protein serum levels in healthy subjects and patients with bac terial pneumonia显示文摘 | Nomo RIH Horio H Fuyuno G | 1995 | Am J Respir crit Care Med1995，152，2： | 1 |
| 11 | Respiratory muscle strength after lung resection with special reference to age pro- cedures of thoracotomy显示文摘 | Nomori H Horio H Fuyuno G | 1996 | Fur J Cardiol Thorac Surg1996，10，35： | 1 |
| 12 | Respiratory muscle strength after lung resection with special reference to age procedures of tho- racotomy显示文摘 | Nomori H Horio H Fuyuno G | 1996 | Eur J Cardiothorac Surg1996，10，5： | 1 |
| 13 | Limited axillary thoracotomy vs video-assisted thoracoscopic surgery for spontaneous pneumothorax显示文摘 | Horio H Nomori H Fuyuno G | 1998 | Surg Endosc1998，12，： | 1 |
| 14 | Respiratory muscle strength after lung resection with special reference to age and procedures of thoracotomy显示文摘 | Nomori H Horio H Fuyuno G | 1996 | European Journal of Cardio-thoracic Surgery1996，10，5： | 1 |
| 15 | Impact of additional pleurodesis in video-assisted thoracoscopic bullectomy for primary spontaneous pneumothorax显示文摘 | Horio H Nomori H Fuyuno G | 2002 | Surg Endosc2002，16，： | 1 |
| 16 | Protein 1 (Clara cell protein) serum levels in healthy subjects and patients with bacterial pneumonia显示文摘 | HORIO H FUYUNO G | 1995 | Am J Respir Crit Care Med1995，152，2： | 1 |
| 17 | Respiratory muscle strength after lung resection with special reference to age procedures of thoracotomy显示文摘 | Nomori H Horio H Fuyuno G | 1996 | Eur J Cardiothorac Surg1996，10，5： | 1 |
| 18 | Limited axillary thoracotomy vs video-assisted thoracoscopic surgery for spontaneous pneumothorax显示文摘 | H. Horio H. Nomori G. Fuyuno R. Kobayashi K. Suemasu | 1998 | Surgical Endoscopy1998，，9： | 1 |
| 19 | Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer显示文摘 | Yuji Maehata Shotaro Nakamura Kiyoshi Fujisawa Motohiro Esaki Tomohiko Moriyama Kouichi Asano Yuta Fuyuno Kan Yamaguchi Issei Egashira Hyonji Kim Motonobu Kanda Minako Hirahashi Takayuki Matsumoto | 2012 | Gastrointestinal Endoscopy2012，，1： | 1 |
| 20 | Contacting metastasis of a fibrous tumor of the pleura显示文摘 | Nomori H Horio H Fuyuno G | 1997 | Eur J Cardiothorac surg1997，12，6： | 1 |
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