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| 1 | High-density circulating fluidized bed gasifier for advanced IGCC/IGFC-Advantages and challenges显示文摘Coal-fired Integrated Gasification Combined Cycle(IGCC)and Integrated coal Gasification Fuel-cell Combined cycle(IGFC)are being developed as high-efficiency electric power generation technology.However,the highest theoretical gross thermal efficiency of the conventional IGCC/IGFC is still below 52%.In order to obtain higher power generation efficiency,an advanced IGCC(A-IGCC)or advanced IGFC(A-IGFC)system making use of the exergy recuperation concept by recycling waste heat from gas turbine or fuel cells for steam gasification of coal and biomass was proposed in our laboratory.Corresponding to this system,a novel high-density triple-bed combined circulating fluidized bed(TBCFB)gasifier,composed of a downer pyrolyzer,a bubbling fluidized bed char gasifier,and a riser combustor,was proposed to replace traditional gasifiers such as the entrained flow bed gasifier.The new system is expected to more effectively utilize the waste heat from gas turbines or fuel cells and the heat produced by the combustion of the unreacted char in the riser combustor for pyrolysis and gasification of coal and biomass.In this short review,the advantages and future challenges in the development of high-density TBCFB gasifier are presented and discussed. | Guoqing Guan Chihiro Fushimi Atsushi Tsutsumi Masanori Ishizuka Satoru Matsuda Hiroyuki Hatano Yoshizo Suzuki | 2010 | Particuology2010，8，6： | 17 |
| 2 | Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity,recapitulating key features of FUS proteinopathy显示文摘Mutations in the fused in sarcoma/translocated in liposarcoma(FUS/TLS)gene have been associated with amyotrophic lateral sclerosis(ALS).FUS-positive neuropathology is reported in a range of neurodegenerative diseases,including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology(FTLDU).To examine protein aggregation and cytotoxicity,we expressed human FUS protein in yeast.Expression of either wild type or ALS-associated R524S or P525L mutant FUS in yeast cells led to formation of aggregates and cytotoxicity,with the two ALS mutants showing increased cytotoxicity.Therefore,yeast cells expressing human FUS protein recapitulate key features of FUSpositive neurodegenerative diseases.Interestingly,a significant fraction of FUS expressing yeast cells stained by propidium iodide were without detectable protein aggregates,suggesting that membrane impairment and cellular damage caused by FUS expression may occur before protein aggregates become microscopically detectable and that aggregate formation might protect cells from FUS-mediated cytotoxicity.The N-terminus of FUS,containing the QGSY and G rich regions,is sufficient for the formation of aggregates but not cytotoxicity.The C-terminal domain,which contains a cluster of mutations,did not show aggregation or cytotoxicity.Similar to TDP-43 when expressed in yeast,FUS protein has the intrinsic property of forming aggregates in the absence of other human proteins.On the other hand,the aggregates formed by FUS are thioflavin T-positive and resistant to 0.5%sarkosyl,unlike TDP-43 when expressed in yeast cells.Furthermore,TDP-43 and FUS display distinct domain requirements in aggregate formation and cytotoxicity. | Kazuo Fushimi Charles Long Neha Jayaram Xiaoping Chen Liming Li Jane Y.Wu | 2011 | Protein & Cell2011，2，2： | 4 |
| 3 | Clonal propagation of Dendrobium Madame Pompdour through apical meriste mculture 显示文摘 | Mujib A Fushimi H Komatsu K | 1994 | Adv Plant Sci1994，7，： | 3 |
| 4 | Enhancement of tumor‐associated antigen‐specific T cell responses by radiofrequency ablation of hepatocellular carcinoma显示文摘 | Eishiro Mizukoshi Tatsuya Yamashita Kuniaki Arai Hajime Sunagozaka Teruyuki Ueda Fumitaka Arihara Takashi Kagaya Taro Yamashita Kazumi Fushimi Shuichi Kaneko | 2013 | Hepatology2013，，4： | 2 |
| 5 | Functional mapping of hospitals by diagnosis - dominant case - mix analysis 显示文摘 | FUSHIMI K HASHIMOTO H IMANAKA Y | 2007 | BMC Health Serv Res2007，7，： | 1 |
| 6 | Macrophage inflammatory protein 3 alpha transgene attracts dendritic cells to established murine tumors and suppresses tumor growth 显示文摘 | Kojima A Moore MA | 2000 | J Clin Invest2000，105，10： | 1 |
| 7 | Use of Hot pressed Refractories for Tundish Slide Gate plates显示文摘 | Kazuo Itoh Toshio Kawamura Tetsurd Fushimi etc | 1996 | Taikabutsu Overseas1996，17，2： | 1 |
| 8 | Macrophage inflammatory protein 3 alpha transgene attracts dendritic cells to established murine tumors and suppresses tumor growth显示文摘 | Fushimi T Kojima A Moore MA | 2000 | J Clin Invest2000，105，： | 1 |
| 9 | Demonstration of muscarinic and nicotinic receptor binding activities of distigmine to treat detrusor underactivity 显示文摘 | Harada T Fushimi K Kato A | 2010 | Biol Pharm Bull2010，33，4： | 1 |
| 10 | Up-regulation of theproapoptotic caspase 2 splicing isoform by a can-didate tumor suppressor,RBM5显示文摘 | Fushimi K Ray P Kar A | 2008 | Proc Natl Acad SciUSA2008，105，15： | 1 |
| 11 | Application of PCR-RFLP and MASA analysis on 18s ribosomal RNA gene sequence for identification of three Ginseng drugs显示文摘 | Fushimi H Komatsu K Isobe M | 1997 | Biol Pharm Bull1997，20，7： | 1 |
| 12 | Acetic acid upregulates the expression of genes for fatty acid oxidation enzymes in liver to suppress body fat accumulation 显示文摘 | KONDO T KISHI M FUSHIMI T | 2009 | J Agricult Food Chem2009，57，13： | 1 |
| 13 | 18S Ribosomal RNA genesequences of three Panax species and the cooresponding ginseng drugs显示文摘 | Fushimi H Komatsu K Isobe M | 1996 | Biol Pharom Bull1996，19，： | 1 |
| 14 | Abnormal hyperintensity in cerebellar efferent pathways on diffusion-weighted imaging in a patient with heat stroke 显示文摘 | Fushimi Y TaM H Kawai H | 2012 | Clin Radiol2012，67，4： | 1 |
| 15 | Inversion of train-dependent nonlinear characterististics of soils using weak and strong motions observed by borehole sites in Japan显示文摘 | Saoh T Fushimi M Tatsumi Y | 2001 | BSSA2001，91，2： | 1 |
| 16 | Molecular analysis of Rheum species used as Rhei Rhizoma based on the chloroplast matK gene and its application for identification显示文摘 | Yang Dong-Ye Fushimi Hirotoshi Cai Shao-qing | 2004 | Biol Pharm Bull2004，27，3： | 1 |
| 17 | Application of PCR- RFLP and MA A analyses on18S Ribosomal RNA gene sequence for the identification of three ginseng drugs显示文摘 | Fushimi H Komatsu K Isobe M | 1997 | Biol Pharm Bull1997，20，： | 1 |
| 18 | Communitybased evaluation of laparoscopic versus open simple closure of perforated peptic ulcers显示文摘 | Kuwabara K Matsuda S Fushimi K | 2011 | World J Surg2011，35，11： | 1 |
| 19 | Do all carbonised charcols have the same chemical structure A model of the chemical structrue of carbonized charcoal显示文摘 | Bourke J Manley-Harris M Fushimi C | 2007 | Industrial and En- gineering Chemistry Research2007，46，18： | 1 |
| 20 | Molecular analysis of medicinally-used Chinese and Japanese Curcuma based on 1 8S RNA gene and trnK gene sequences显示文摘 | Cao Hui Sasaki Yohei Fushimi Hirotoshi | 2001 | Biol Pharm Bull2001，24，12： | 1 |
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