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| 1 | Cathepsin D: Autoantibody profiling as a diagnostic marker for cancers显示文摘Current diagnostic assays for many cancers are antigen-based and rely on the detection of circulating proteins that are associated with a particular cancer.These assays depend on the expression,synthesis,and release of specific proteins by cells(e.g.,tumor cells)through either active secretion or shedding,or as a consequence of cell death(either necrosis or apoptosis).As such,these antigenic proteins must“escape”the primary site of disease,saturate the antigen-processing capacity of the individual’s immune components,gain access to the circulation,and reach a sufficient steady-state concentration to be detected by enzyme-or radiolabel-based immunoassays.These events usually occur after the initial establishment of disease.Thus,and despite the fact that certain specific antigenic epitopes exhibit common recognition among patients with the same tumor types,the use of these antigen-based cancer assays has not been widely accepted in clinical practice,and many individual countries differ in the use of these potential diagnostic factors.Lately,an increasing number of studies demonstrated that procathepsin D secreted from cancer cells,acts as a mitogen on cancer cells and stimulates their pro-invasive and pro-metastatic properties.In this report,we focused on the possibility to use antiprocathepsin D autoantibodies as a diagnostic and/or predictive marker for cancers. | Vaclav Vetvicka Martin Fusek | 2013 | World Journal of Clinical Oncology2013，4，1： | 2 |
| 2 | Extracellular aspartic proteinases from Candida albicans, Candida tropicalis, and Candida parapsilosis yeasts differ substantially in their specificities显示文摘 | Fusek M Smith E A Monod M | 1994 | Biochemistry1994，33，： | 1 |
| 3 | Cathepsin D- many functions of one aspartic protease显示文摘 | Benes P Vetvieka V Fusek M | 2008 | Crit Rev Oncol Hematol2008，68，1： | 1 |
| 4 | Extracellular aspartic pro- teinases from Candida albicans , Candida tropicalis , and Candida parapsilosis yeasts differ substantially in their specifici- ties 显示文摘 | Fusek M Smith EA Monod M | 1994 | Biochemistry1994，33，32： | 1 |
| 5 | Cathepsin D many functions of one aspartic protease显示文摘 | Benes P Vetvicka V Fusek Met et aI | 2008 | Crit Rev Oncol Hematol2008，68，1： | 1 |
| 6 | Dual role of cathepsin D:ligand and protease显示文摘 | Fusek M Vetvicka V | 2005 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repu2005，149，1： | 1 |
| 7 | The positive influence of a cholinergic-anticholinergic pretreatment and antidotal treatment on rats poisoned with supralethal doses of soman显示文摘 | Kassa J Fusek J | 1998 | Toxicology1998，128，1： | 1 |
| 8 | Cathepsin D--many functions of one aspartic protease显示文摘 | Benes P Vetvicka V Fusek M | | 0，，01： | 1 |
| 9 | Treatment of organophosphate in- toxication using cholinesterase reactivators, facts and fiction 显示文摘 | Bajgar J Fusek J Kuca K | 2007 | Mini Rev Med Chem2007，7，5： | 1 |
| 10 | Cathepsin D-many functions of one aspartic protease显示文摘 | Benes P Vetvicka V Fusek M | 2008 | Crit Rev Oncol Hemato12008，68，1： | 1 |
| 11 | Cathepsin D many functions of one aspartic protease 显示文摘 | Benes P Vetvicka V Fusek Met | 2008 | Crit Rev Oncol Hematol2008，68，1： | 1 |
| 12 | Protective rote for interferon-beta in Coxsackievirus B3 infection显示文摘 | Deonarain R Cerullo D Fusek | 2004 | Circulation2004，110，23： | 1 |
| 13 | Effect of procathepsin D and its activation peptide on prostate cancer cells Cancer Lett显示文摘 | Vetvicka V Vetvickova J Fusek M | 1998 | Cancer Lett1998，129，1： | 1 |
| 14 | Procathepsin D in breast cancer:what do we know? Effects of ribozymes and other inhibitors显示文摘 | Vetvicka V Benes P Fusek M | 2002 | Cancer Gene Ther2002，9，10： | 1 |
| 15 | Chemical aspects of pharma-cological prophylaxis against nerve agent poisoning显示文摘 | Bajgar J Fusek J Kassa J | 2009 | Curt Med Chem2009，16，23： | 1 |
| 16 | Chemical aspects of pharmaco-logical prophylaxis against nerve agent poisoning显示文摘 | Bajgar J Fusek J Kassa J | | 0，，23： | 1 |
| 17 | Effects of panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in somanpoisoned rats 显示文摘 | Kassa J Fusek J | 1997 | Hum Exp Toxicol1997，16，10： | 1 |
| 18 | Mitogenic function of human procathepsin D:the role of the propeptide显示文摘 | Fusek M Vetvicka V | | 0，，3： | 1 |
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