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| 1 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 2 | Effects of infusing milk precursors into the artery on rumen fermentation in lactating cows显示文摘This experiment was conducted to investigate the effects of infusing milk precursors into the external pudic artery on rumen fermentation in lactating dairy cows. Eight multiparous Holstein cows were randomly assigned to Group A(experimental group) and Group B(control group) with 4 cows each. A2×4 complex factor crossover design was used. Cows in Group A were fed corn straw as the only roughage, and cows in Group B were fed mixed roughage. The experiment was divided into two periods.In the first period, cows in Group A, received treatments: 1) a basal infusate as a control(CSC); 2) a milk fat precursor infusion including C16:0, C18:0, C18:1 c9, C18:2 c6, C18:3 n3, acetic acid(CSF); 3) a milk protein precursor infusion including 16 amino acids(CSA); 4) the mixed infusion of milk fat and protein precursors(CSFA). And meanwhile, cows in Group B were infused the basal infusate as a control group. In the second period, the cows in both Groups A and B were crossed over, which cows in Group A were named as Group B and the cows originally in Group B were in Group A. The experimental results showed that cows in experimental group had higher ruminal pH compared with the control, and ruminal pH in CSC, CSF, CSA were significantly higher than those in their respective control group(P < 0.05). The concentration of ammonia nitrogen(NH_3-N) was significantly higher in CSA and CSFA compared with Group B(P < 0.05). We also observed that the infusion of mixed amino acids significantly increased the bacterial protein(BCP) content in rumen(P < 0.05) and influenced the rumen acetic acid concentration as well as the acetic to propionic ratio(P < 0.05). Milk fat precursors infusion significantly affected butyric acid concentration(P < 0.05). In addition, the content of lipopolysaccharide(LPS) in CSA was significantly higher than that in the control group(P < 0.05). It is concluded that the milk precursors infused into external pudic artery caused feedback effects on ruminal fermentation under the corn straw roughage conditions. The milk protein precursor increased the ruminal pH, the contents of BCP and acetic acid, which adjust rumen fermentation and improve milk performance. | Xianjue Wang Changjin Ao Khas-Erdene Shuaiwang Liu Chen Bai Fuquan Zhang Ying Zhang Peng Gao | 2016 | Animal Nutrition2016，，2： | 3 |
| 3 | RUVBL2, a novel AS160-binding protein, regulates insulinstimulated GLUT4 translocation显示文摘在脂肪和肌肉房间,刺激胰岛素的葡萄糖举起被葡萄糖 transporter 主要调停 4 (GLUT4 ) ,哪个到响应胰岛素刺激的房间表面的从细胞内部的分隔空间的 translocates。AS160 是 Akt 的底层之一并且在调整胰岛素的 GLUT4 translocation 起重要作用。在这研究,(RUVBL2 ) 象 RuvB 一样蛋白质 2 用与集体 spectrometry 相结合的哺乳动物的双人脚踏车亲密关系纯化(龙头) 作为新 AS160 有约束力的蛋白质被识别。在 3T3-L1 adipocytes, RUVBL2 高度被表示并且在 cytosol 主要是分布式的。在 adipocytes 的 RUVBL2 的弄空通过减少刺激胰岛素的 AS160 phosphorylation 禁止刺激胰岛素的 GLUT4 translocation 和葡萄糖举起。然而,人的 RUVBL2 的介绍能颠倒这禁止的效果。这些数据建议 RUVBL2 通过它和 AS160 的相互作用在刺激胰岛素的 GLUT4 translocation 起一个重要作用。 | Xiangyang Xie Yu Chen Peng Xue Yong Fan Yongqiang Deng Gong Peng Fuquan Yang Tao Xu | 2009 | Cell Research2009，19，9： | 3 |
| 4 | Proteomic analysis of the mitochondria from Caenorhabditis Elegans显示文摘Mitochondria are one of the most important organelles in a cell, playing essential roles in cell physiological processes including energy production, metabolism, ion homeostasis, aging | Jing Li, Tanxi Cai, Peng Wu, Ziyou Cui, Xiulan Chen, Junjie Hou, Zhensheng Xie, Peng Xue, Pingsheng Liu, Fuquan Yang Proteomic Platform & National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 100101 | 2009 | 生物物理学报2009，25，S1： | 1 |
| 5 | A new dimethyl labeling-based SID-MRM-MS method and its application to three proteases involved in insulin maturation显示文摘 | Dongwan Cheng Li Zheng Junjie Hou Jifeng Wang Peng Xue Fuquan Yang Tao Xu | 2015 | Biophysics Reports2015，1，2： | 1 |
| 6 | Overlying water fluoride concentrations influence dissolved organic matter composition and migration from pore water in sediment via bacterial mechanisms显示文摘Fluoride(F^(-))is widespread in aquatic environments;however,it is not clear whether the fluctuation of F^(-)concentrations in overlying lake water affects the composition and migration of dissolved organic matter(DOM)from sediment.A case study was presented in Sand Lake,China,and an experiment was conducted to analyze the influence of different F^(-)concentrations in overlying water on DOM characteristics.Diffusion resulted in similarities in DOM components between overlying and pore waters,and bacterial activities and enzyme variation resulted in differences between them.Higher F^(-)concentrations in overlying water resulted in a higher pH of pore water,which favored the enrichment of protein-like substances.Higher F^(-)concentrations caused lower DOM concentrations and lower maximum fluorescence intensities(Fmax)of protein-like components in pore water.The F^(-)concentrations had significantly negative correlations with Shannon indexes(P<0.05).Thiobacillus influenced the migration of tyrosinelike substances by decreasing the pH of pore water.Trichococcus and Fusibacter altered the Fmax of protein-like,humic-like,and fulvic-like substances.The F^(-)concentrations affected the DOM composition and migration due to the response of functional bacterial communities,which were positively correlated with the relative abundance of Thiobacillus and negatively correlated with the relative abundances of Trichococcus and Fusibacter.The high F^(-)concentrations influenced the biosynthesis and degradation of protein-like substances by shifting the abundances of the relevant enzymes.The results of this study may provide ideas for investigating DOM cycling under the influence of F^(-),especially in lakes with fluctuations in F^(-)concentrations. | Xiang Zhu Zibo Wang Yidan Luo Yushen Ma Zhipeng Xu Longmian Wang Fuquan Peng Qingqing Pang Yiping Li Fei He Bin Xu | 2022 | Environmental Science and Ecotechnology2022，，2： | 0 |
| 7 | Protomer Roles in Chloroplast Chaperonin Assembly and Function显示文摘三叶绿体 CPN60 protomers (CPN60, CPN601,和 CPN602 ) 的单个角色并且他们是否并且怎么被装配进功能的 chaperonin 建筑群在 Chlamydomonas reinhardtii 被调查。包含所有三个潜在的子单元的蛋白质建筑群在 Chlamydomonas 被识别,并且他们在 Escherichia coli 的合作表示产出包含所有三个子单元(CPN6012 ) 的 oligomers 的一张同类的人口,与与 tetradecameric 结构一致的分子的重量。当 CPN60 的 homo-oligomers 能形成时,当 CPN60 是在场的, CPN602 的 homo-oligomers 乐意地面对 ATP 和另外的 protomers 被变成 hetero-oligomers 时,他们戏剧性地被减少。ATP 水解作用引起了 CPN60 oligomers 拆卸并且驱使净化的 protomers 重新组成 oligomers invitro,建议 CPN60 oligomers 的动态性质依赖于 ATP。在 5:6:3 比率的仅仅 hetero-oligomeric CPN6012,包含的 CPN60, CPN601,和 CPN602 子单元,与 GroES 机能上地合作了。CPN60 和 CPN60 子单元的联合,然而并非单个子单元在有子单元识别的 E.coli 的独自一个的、补充 GroEL 功能特性。在 Chlamydomonas 的 CPN60 子单元的下面规定导致了一个慢生长缺点和无能自造营养物质地成长,显示 CPN60 invivo 的必要角色。 | Cuicui Bai Peng Guo Qian Zhao Zongyang Lv Shijia Zhang Fei Gao Liyan Gao Yingchun Wang Zhixi Tian Jifeng Wang Fuquan Yang Cuimin Liu | 2015 | Molecular Plant2015，8，10： | 0 |
| 8 | Mitochondrial Proteomics显示文摘Mitochondria are one of the most important organelles in a cell, playing essential roles in cell physiological processes including energy production, metabolism, ion homeostasis, aging | Fuquan Yang, Jing Li, Tanxi Cai, Xiulan Chen, Ziyou Cui, Junjie Hou, Zhensheng Xie, Peng Xue, Peng Wu, Pingsheng Liu Institute of Biophysics, Chinese Academy of Sciences, No.15 Datun Road Chaoyang District, Beijing 100101, China | 2009 | 生物物理学报2009，25，S1： | 0 |
| 9 | Improved identification of glycerophospholipids using a linear ion trap mass spectrometer(LTQ) with Pulsed Q Collision Induced Dissociation(PQD)显示文摘Phospholipids are the major building blocks of the biological membranes. Additionally, phospholipids modulate membrane trafficking and metabolites derived from their | Tanxi Cai, Jing Li, Peng Xue, Zhengsheng Xie, Ziyou Cui, Junjie Hou, Xiulan Chen, Peng Wu, Pingsheng Liu, Fuquan Yang Proteomic Platform & National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 100101 | 2009 | 生物物理学报2009，25，S1： | 0 |
| 10 | Quantitative mitochondrial proteome of pancreatic INS-1β cells stimulated with prolonged high glucose using SILAC显示文摘Most type 2 diabetics are accompanied with deficiency of insulin secretion and hyperglycemia. It has reported that glucose-stimulated insulin secretion of β cell (GSIS) | Xiulan Chen , Ziyou Cui , Junjie Hou, Zhensheng Xie, Peng Xue, Jing Li, Tanxi Cai, Fuquan Yang Proteomic Platform & National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 100101 | 2009 | 生物物理学报2009，25，S1： | 0 |
| 11 | Shotgun Proteomics Mapping the Protein Composition and Their Phosphorylation Signaling Network of Rat INS-1 β Cell Mitochondria显示文摘Mitochondria play important roles in cellular physiological functions and various diseases. In well accepted glucose-stimulated insulin secretion (GSIS) model of pancreatic β cells, | Ziyou Cui, Junjie Hou, Xiulan Chen, Jing Li, Tanxi Cai, Zhensheng Xie, Peng Xue, Peng Wu, Fuquan Yang Proteomic Platform & National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China | 2009 | 生物物理学报2009，25，S1： | 0 |
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