|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma显示文摘Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via na?ve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid)(PEG-PLGA) nanoparticles. Neutrophil membranecoated nanoparticles(NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models,celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma. | Xi Cao Ying Hu Shi Luo Yuejing Wang Tao Gong Xun Sun Yao Fun Zhirong Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 9 |
| 2 | 间苯二甲酸连接的氢键导致的二维锌配位聚合物的合成及晶体结构显示文摘A H-bond induced two-dimensional in finite coordination polymer[Zn(1,3-BDC)(Im)2]n·2nCH3 OH(1,3-BDC =1,3-benzenedicarboxylate,Im =imidazole)was synthesized and crystallo-graphically determined by X-ray dif fraction.The crystal structure belongs to monoclinic system with space group C2/c.a=23.1836(2),b=10.1905(1),c=17.0118(2)?,β=115.099°,V=3639.58(6)?3,D=1.499g·cm-3,Z =8,F000=1688,μ=1.384mm-1,R1=0.0715,wR2=0.1645.Each Zn?ion is four-coordinated with a geome try of distorted tetrahedron.Each 1,3-BDC acts as a bridge to bond two neighboring zinc ions,leading to an infinite o ne-dimensional chainlike coordination polymer.Each chain wa s linked by hydrogen bonds with its neighbors to form a two-dimensional net. | 李彬 孙跃飞 苟少华 姚景才 Suchada Chantrapromma Hoong-Kun Fun | 2001 | 无机化学学报2001，17，6： | 6 |
| 3 | Avian influenza virus directly infects human natural killer cells and inhibits cell activity显示文摘Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity. | Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung Lau Wenwei Tu | 2017 | Virologica Sinica2017，32，2： | 4 |
| 4 | 两种新型吡啶盐的合成,表征及双光子性质研究显示文摘本文报道了两种新的吡啶盐的合成,用元素分析、红外光谱、单晶X-射线衍射进行了表征。研究了它们的紫外光谱、荧光光谱和光限幅特性,发现它们的DMF溶液对1064nm皮秒脉冲激光表现出明显的光限幅特性。 | 周虹屏 郝扶影 张居舟 赵祖志 李东梅 吴杰颖 田玉鹏 Hoong-Kun Fun | 2004 | 无机化学学报2004，20，10： | 4 |
| 5 | 一种具有双光子活性的新型吡啶盐的合成、表征及性质显示文摘合成了1种新的DπA结构的吡啶盐,通过红外、元素分析、热重分析、单晶X射线衍射对化合物的结构进行了表征。研究了它的荧光光谱,用1064nm皮秒脉冲激光研究了它的三阶非线性光学特性。结果表明,该吡啶盐的双光子吸收系数β=0.1047cm/GW,双光子吸收截面σ=3.2473×10-46cm4·s·photon-1,当泵浦能量达到1.677mJ时,上转换效率达到1.9%。 | 周虹屏 郝扶影 张居舟 赵祖志 李东梅 吴杰颖 田玉鹏 Hoong-Kun Fun | 2005 | 应用化学2005，22，6： | 4 |
| 6 | Surgical outcomes for unilateral superior oblique palsy in Chinese population: a retrospective study显示文摘AIM: To evaluate the outcome after surgery for unilateral superior oblique(SO) palsy in Chinese.METHODS: The medical records of 39 patients that underwent surgery for unilateral SO palsy between January 2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively reviewed. All surgeries were performed by a single surgeon. Pre-operative assessments for vertical deviation, cyclo-deviation, and Knapp's classification were obtained to determine the nature and degree of surgical correction.Vertical deviation was measured at 1wk; 1, 6mo and on last follow-up day post-operatively. Cyclo-deviation was measured on last follow-up day post-operatively.RESULTS: During the 10 y period, 39 subjects were recruited. The most common etiology was congenital(94.9%). Knapp's Type III(66.7%) and Type I(12.8%)classifications were the most common subtypes. To treat SO palsy, the most common surgical procedures were:isolated inferior oblique(IO) anteriorization(41.0%),isolated IO myectomy(10.3%), and isolated IO recession(10.3%). At 3.5 ±2.1y post-operatively, the vertical deviation was significantly reduced(15.1 ±6.2 PD versus0.5±1.4 PD, P <0.0001) without significant improvement in cyclo-deviation(P =0.5). Initial vertical deviation was correlated with cyclo-torsion(r =0.4, P =0.007). Those with over-correction had greater initial vertical deviation(19.4±7.2 PD versus 13.2±4.3 PD, P =0.003). After a single operation, 84.6% of subjects achieved a vertical deviation within ±3 PD.· CONCLUSION: The majority of subjects achieved corrected vertical deviation after a single surgery although there was no improvement in cyclo-deviation.Those with over-correction of primary position deviation had greater preoperative vertical deviation and it may be related to simultaneous multiple muscle surgery. | Gordon Shing Kin Yau Victor Tak Yau Tam Jacky Wai Yip Lee Theo Tak Kwong Chan Can Yin Fun Yuen | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 4 |
| 7 | Diabetic muscle infarction in end-stage renal disease: A scoping review on epidemiology, diagnosis and treatment显示文摘Diabetic muscle infarction(DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to arterial occlusion. People with DMI may have coexisting end-stage renal disease(ESRD) but little is known about its epidemiology and clinical outcomes in this setting. This scoping review seeks to investigate the characteristics, clinical features, diagnostic evaluation, management and outcomes of DMI among people with ESRD. Electronic database (Pub Med/MEDLINE, CINAHL, SCOPUS and and EMBASE) searches were conducted for ('diabetic muscle infarction' or 'diabetic myonecrosis') and('chronic kidney disease' or 'renal impairment' or 'dialysis' or 'renal replacement therapy' or 'kidney transplant ') from January 1980 to June 2017. Relevant cases from reviewed bibliographies in reports retrieved were also included. Data were extracted in a standardized form. A total of 24 publications with 41 patients who have ESRD were included. The mean age at the time of presentation with DMI was 44.2 years. Type 2 diabetes was present in 53.7% of patients while type 1 in 41.5%. In this cohort, 60.1% were receiving hemodialysis, 21% on peritoneal dialysis and 12.2% had kidney transplantation. The proximal lower limb musculature was the most commonly affected site. Muscle pain and swelling were the most frequent manifestation on presentation. Magnetic resonance imaging (MRI) provided the most specific findings for DMI. Laboratory investigation findings are usually non-specific. Non-surgical therapy is usually used in the management of DMI. Short-term prognosis of DMI is good but recurrence occurred in 43.9%. DMI is an uncommon complication in patients with diabetes mellitus, including those affected by ESRD. In comparison with unselected patients with DMI, the characteristics and outcomes of those with ESRD are generally similar. DMI may also occur inkidney transplant recipients, including pancreas-kidney transplantation. MRI is the most useful diagnostic investigation. Non-surgical treatment involving analgesia, optimization of glycemic control and initial bed rest can help to improve recovery rate. However, recurrence of DMI is relatively frequent. | Tuck Yean Yong Kareeann Sok Fun Khow | 2018 | World Journal of Nephrology2018，7，2： | 4 |
| 8 | 丙二腈类化合物的室温固相合成、结构及单双光子荧光性质显示文摘固相反应合成了新型丙二腈类化合物。反应 0 5h完成 ,产率高达 93%以上。采用IR、UV、1HNMR及元素分析对产物进行了表征 ,并通过单晶X射线衍射确定了其中 1种化合物的结构。研究表明 ,产物具有单光子和双光子吸收荧光效应 ,并表现出类似的溶剂效应。 | 马文 张胜义 吴杰颖 田玉鹏 FUN Hoong-Kun | 2003 | 应用化学2003，20，9： | 2 |
| 9 | [Mg(H-Sulf)(H_2O)_5](H-Sulf)·5H_2O的合成、晶体结构和谱学表征显示文摘柳氮磺胺吡啶(H3-Su lf)与氢氧化镁反应得到化合物[M g(H-Su lf)(H2O)5](H-Su lf).5H2O。用元素分析、U v-V is、荧光、IR光谱和单晶X-射线衍射方法对该化合物进行表征。化合物的化学式:C36H46M gN8O20S2,M r=999.24,三斜晶系,P-1空间群,晶胞参数:a=1.115 16(13)nm,b=1.544 71(19)nm,c=1.604 71(19)nm,=α115.654(2),°β=107.909(2),°γ=91.861(2),°V=2.326 4(5)nm3,Z=2,Dc=1.426 M g/m3,R 1=0.130,wR 2=0.259(I>2σ(I)),S=1.048。化合物为离子型化合物,由阳离子[M g(H-Su lf)(H2O)5]+,阴离子[H-Su lf]-和5个结晶水组成。其中心金属M g(Ⅱ)离子采取六配位变形的八面体几何构型,周围被5个H2O和1个来自柳氮磺胺吡啶的单齿配位的羧基O所包围,羟基和吡啶N均未参与配位。化合物通过复杂的分子内和分子间氢键作用形成三维的超分子结构。 | 康澍 陈振锋 梁宇宁 李冬青 梁宏 FUN Hoong-kun | 2006 | 广西师范大学学报(自然科学版)2006，24，3： | 2 |
| 10 | 硫代碳酰肼缩邻香草醛的合成、晶体结构及非线性光学性质的研究显示文摘报道合成了一种新的化合物硫代碳酰肼缩邻香草醛(1)(C19H22N5O4S,Mr=416.48),通过元素分析、红外光谱、紫外光谱和氢核磁共振谱对其结构进行了表征。用X-射线单晶衍射测定了其晶体结构。结果表明:晶体属于三斜晶系,P1-空间群,晶胞参数:a=0.9983(1)nm,b=1.0509(1)nm,c=1.0748(1)nm,α=90.089(2)°,β=110.033(2)°,γ=103.069(2)°。用开孔Z-扫描技术在523 nm脉冲激光波长下研究了该化合物的DMF溶液的三阶非线性光学性质。单晶数据注册编号:CCDC 240088。 | 周虹屏 李东梅 卜继琴 金凤 朱永敏 张居舟 吴际 吴杰颖 田玉鹏 Suchada Chantrapromma FUN Hoong-Kun | 2006 | 化学世界2006，47，2： | 2 |
| 11 | 配位聚合物[HgI_2(bpea)]_n[bpea=1,2-双(4-吡啶基)乙烷]的合成结构表征和光学折射效应(英文)显示文摘制备44连吡啶基二卤加和物MX244′bipyn仍然有较大困难。这类化合物数量不多且已报道的多为难处理的微晶材料。本文在室温下通过简单的操作合成了新的碘化汞连吡啶乙烷加和物HgI2bpean。X射线单晶衍射分析表明其中的汞原子通过与两个碘原子以及吡啶乙烷的两个氮原子配位形成扭曲的四面体构型。每个HgI2单元由bpea桥连形成锯齿状链。其非线性光学性质用8纳秒激光在532nm波长进行了研究。该化合物相对于入射光表现为一定的光学吸收和强的自聚焦效应,其三阶非线性吸收系数α2=1.1×10-11m·W-1折射系数n2=5.29×10-18m2·W-1。 | 牛云垠 宋瑛林 侯红卫 郑和根 FUN Hoong -Kun 忻新泉 | 2001 | 无机化学学报2001，17，5： | 2 |
| 12 | Synthesis and structures of two novel one-dimensional mixed-valence iron molybdophosphate matrices显示文摘 | ZHOU Y ZHANG L FUN H | 2001 | New J Chem2001，25，： | 1 |
| 13 | Relationship of the optic nerve to the posterior paranasal sinuses: a CT anatomic study 显示文摘 | Delano MC Fun FY Zinreich SJ | 1996 | Am J Neuroradiol1996，17，4： | 1 |
| 14 | The ongoing challenges of regional and general anaesthesia in obstetrics显示文摘 | Alex T.H. Sia Wendy L. Fun Terry U. Tan | 2009 | Best Practice & Research Clinical Obstetrics & Gynaecology2009，，3： | 1 |
| 15 | Creative destruction and the water town of Luzhi,China显示文摘 | C N Fun | 2008 | Tourism Management2008，29，： | 1 |
| 16 | A Quantitative Genetic Study of Verticillium Wilt Resistance Among Selected Lines of Upland Cotton 显示文摘 | VERHALEN L M BRINKERHOFF L A KWEE-CHONG FUN | 1971 | Crop Science1971，，11： | 1 |
| 17 | Proportional-integral-plus control of an intelligent excavator 显示文摘 | fun Gu James Taylor Derek Seward | 2004 | Construction-Aided Civil and Infrastructure Engineering2004，，19： | 1 |
| 18 | Microstruc ture and mechanical properties of SiC nanowires rein- forced hydroxyapatite coating on carbon/carbon compos- ites显示文摘 | Qian Gang Fun Cai Ge Gu He Jun Li | 2013 | Materials Science Engineering A2013，，13： | 1 |
| 19 | Spri- na extracts enhances chicken macrophage ction after in vitro exposure显示文摘 | Qur uli fun of Qur tia Pou eshi M A Kiold M T A:L R A | 1995 | Journal Poult eshi i of itry ry Science1995，3，4： | 1 |
| 20 | Case detection, diagnosis, and treatment of patients with primary aldosteronism : an endocrine society clinieal practice guideline显示文摘 | Fun der JW Carey RM Fardel la C | 2008 | J Clin Endoerinol Metab2008，93，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员