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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 3 | Tanshinone Ⅱ A protects cardiac myoeytes against oxidative stress-triggered damage and apoptosis显示文摘 | Fu J Huang H Du J Pi R Chen J Liu P | 2007 | Eur J Pharmacol2007，568，13： | 1 |
| 4 | Characteristics and surface energy of silicon - doped diamond - like carbon films fabricatedby plasma immersion ion implantation and deposition 显示文摘 | Wan G J Yang P Fu R K Y | 2006 | Diamond and Related Materials2006，15，： | 1 |
| 5 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 6 | Long-range scanning for scanning tunneling microscopy显示文摘 | Fu J Young R D Vorburger T V | 1992 | Review of Scientific Instruments1992，63，4： | 1 |
| 7 | Villanova,regioselective pyrazole formation显示文摘 | Fustero S Roman R Fu J etal | 2008 | J Org Chem2008，73，21： | 1 |
| 8 | 查看详情显示文摘 | Zhang Y H Fu S Y Li R K Y Wu J T Li L F Ji J H | | 0，，11： | 1 |
| 9 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 10 | Recovery of soianesol from tobacco as a value- added byproduct for alternative applications显示文摘 | MACHADO P A FU H KRATOCHVIL R J | 2010 | Bioresource technology2010，101，3： | 1 |
| 11 | Effect of seiencing of HER2/neu gene in anti-BPDE-transformed cells 显示文摘 | Jiang Y Fu J Greenlee A R Shen YoDuan H Chen X | 2009 | Toxicol In Vitro2009，23，： | 1 |
| 12 | The method of lower and upper solutions for fourth-order two- point boundary value problems 显示文摘 | Ma R Y Zhang J H Fu S M | 1997 | J Math Anal Appl1997，215，2： | 1 |
| 13 | Surface modifications of electrode materials for lithium ion batteries显示文摘 | FU L J LIU H LI C WU Y P RAHM E HOLZE R WU H Q | 2006 | Solid State Sci2006，8，2： | 1 |
| 14 | Mining N-most inter-esting itemsets 显示文摘 | FU A W C KWONG R W W TANG J | 2000 | ISMIS2000，12，4： | 1 |
| 15 | A Genetic Algorithm for Optimal Design of an Inflatable Knee Bolster 显示文摘 | Fu Y Yang R J Yeh I | 2004 | Structural and Multidisciplinary Optimization2004，26，34： | 1 |
| 16 | Expropriation through loan guarantees to related parties:evidence from China 显示文摘 | BERKMAN H COLE R FU L J | 2009 | Journal of Banking and Finance2009，33，： | 1 |
| 17 | Hollow carbon nanospheres with superior rate capability for sodium-based batteries显示文摘 | Tang K Fu L White R J | 2012 | Advanced Energy Materials2012，2，7： | 1 |
| 18 | Delamination analysis of sandwich beam : high order theory 显示文摘 | Fu M H Liu Z Q Yin J R | 2002 | AIAAJ2002，40，5： | 1 |
| 19 | Purification ofpolyphenoloxidase and the browning control of litchi fruit byglu-tathione and citric acid显示文摘 | JIANG Y M FU J R ZAUBERMAN G | 1999 | Journal of the Science of Foodand Agriculture1999，79，7： | 1 |
| 20 | Outcomes of phacoemulsification after descemet membrane endothelial keratoplasty显示文摘 | Musa FU Cabrerizo J Quilendrino R | 2013 | J Cataract Refract Surg2013，39，6： | 1 |
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