|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition显示文摘The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis,homeostasis and function.Vascular endothelial growth factor-a(VEGFA)has been commonly recognized as a pro-angiogenic factor in vertebrate developmental,physiological and pathological conditions for decades.Here we report a novel finding that genetic ablation of CDP-diacylglycerol synthetase-2(CDS2),a metabolic enzyme that controls phosphoinositide recycling,switches the output of VEGFA signaling from promoting angiogenesis to unexpectedly inducing vessel regression.Live imaging analysis uncovered the presence of reverse migration of the angiogenic endothelium in cds2 mutant zebrafish upon VEGFA stimulation,and endothelium regression also occurred in postnatal retina and implanted tumor models in mice.In tumor models,CDS2 deficiency enhanced the level of tumorsecreted VEGFA,which in-turn trapped tumors into a VEGFA-induced vessel regression situation,leading to suppression of tumor growth.Mechanistically,VEGFA stimulation reduced phosphatidylinositol(4,5)-bisphosphate(PIP2)availability in the absence of CDS2-controlled-phosphoinositide metabolism,subsequently causing phosphatidylinositol(3,4,5)-triphosphate(PIP3)deficiency and F0X01 activation to trigger regression of CDS2-null endothelium.Thus,our data indicate that the effect of VEGFA on vasculature is context-dependent and can be converted from angiogenesis to vascular regression. | Wencao Zhao Le Cao Hanru Ying Wenjuan Zhang Dantong Li Xiaolong Ziiu Wenzhi Xue Shuang Wu Mengye Cao Cong Fu Haonan Qi Yimei Hao Yun-Chi Tang Jun Qin Tao PZhong Xiaoxi Lin Luyang Yu Xuri Li Lin Li Dianqing Wu Weijun Pan | 2019 | Cell Research2019，29，11： | 9 |
| 2 | A mild solvothermal route to nanocrystalline titanium diboride显示文摘 | Yunle Gu Yitai Qian Luyang Chen Fu Zhou | 2002 | Journal of Alloys and Compounds2002，，1： | 1 |
| 3 | Far-infraredassisted extraction followed by MEKC for the simultaneous determination of flavones and phenolic acids in the leaves of Rhododendron mucronulatum Turcz显示文摘 | FU Yuejiao ZHANG Luyang CHEN Gang | 2012 | Journal of separation science2012，35，3： | 1 |
| 4 | General iteration algorithms for classification ratemaking 显示文摘 | Fu Luyang Cheng-Sheng Peter Wu | 2007 | Variance2007，1，2： | 1 |
| 5 | Research on Route Optimization of Battlefield Collection Equipment Based on Improved Ant Algorithm显示文摘Accurate battlefield collection plays a crucial role in the end of thewar. How to effectively improve the ability of accurate battlefield collection hasbecome a hot issue of research. However, the existing support force is limited. Tosolve the problem, an improved ant algorithm is applied to the path optimizationproblem of battlefield collection equipment. A model for solving the collectionpath optimization problem of battlefield collection vehicles was designed, andan example was used to simulate calculations. The final results show that thealgorithm is effective and practical,which improves the army’s ability to accuratelycollect equipment in the modern battlefield. | Haigen Yang Wang Sun Xiao Fu Gang Li Luyang Li | 2021 | 国际计算机前沿大会会议论文集2021，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员