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| 1 | Conjugated Polymer Nanomaterials for Phototherapy of Cancer显示文摘Due to the excellent properties including high specificity,low side-effect and good biocompatibility,conjugated polymer nanomaterials have been served as efficient anticancer reagents in die past decades.According to the developed anticancer systems based on conjugated polymer nanomaterials,it could be summarized into three main cancer therapy strategies:photodynamic therapy(PDT),photothermal therapy(PTT)and combination therapy.In this mini review,we provide a brief introduction to three different cancer therapy modes,their mechanisms and potential biological applications.Furthermore,some perspectives on the further development of conjugated polymer nanomaterials are proposed in the territory of anticancer precision medicine. | FU Xuancheng BAI Haotian LYU Fengting LIU Libing WANG Shu | 2020 | Chemical Research in Chinese Universities2020，36，2： | 2 |
| 2 | Downregulation of hsa_circ_0002198 inhibits keloid fibroblast activities in vitro by reducing NLRP3 inflammasome activity显示文摘The levels of hsa circular RNA_0002198(hsa_circ_0002198)have been found to be significantly upregulated in keloid dermal fibroblasts.However,the functional role of hsa_circ_0002198 in keloid fibroblasts and the underlying molecular mechanism for its effects have not been reported.In this study,the levels of hsa_circ_0002198 and nucleotide-binding and oligomerization domain,leucine rich repeat and pyrin domain containing 3(NLRP3)expression in keloid scar tissues and adjacent normal skin tissues were determined by quantitative real-time PCR and western blotting,respectively.In vitro models of keloid tissue were created by culturing primary keloid fibroblasts obtained from patients.A series of functional experiments,including CCK-8 assays,Transwell assays,and ELISA assays were performed to analyze the functional role of hsa_circ_0002198/NLRP3.Our data showed that hsa_circ_0002198 and NLRP3 were upregulated in keloid scar tissues when compared with adjacent normal tissues.Knockdown of hsa_circ_0002198 expression significantly suppressed cell proliferation,migration,and invasion,and those effects could be partially reversed by forced NLRP3 overexpression in keloid fibroblasts.At the molecular level,knockdown of hsa_circ_0002198 downregulated the levels of Col I,α-SMA,and NLRP3 proteins,as well as the levels of TGF-β,IL-1ß,and IL-33,but upregulated caspase 3 expression in keloid fibroblasts.All those effects were partially reversed after NLRP3 overexpression.In conclusion,our results suggest hsa_circ_0002198 as a potential target for treating keloid lesions. | LEI FU JINGWEN JIANG XUEWU CHEN FENGTING ZHU HUI ZHANG | 2022 | BIOCELL2022，46，5： | 1 |
| 3 | Effects of poly (vinyl alcohol) (PVA) content on preparation of novel thioi-functionalized meso- porous PVA/SiO2 composite nanofiber membranes and their application for adsorption of heavy metal ions from aqueous solution显示文摘 | Shengju Wu Fengting Li Hongtao Wang Lin Fu I3ingru Zhang Guangtao Li | 2010 | Polymer2010，51，： | 1 |
| 4 | Consequence of shape elongation on emission asymmetry for colloidal CdSe/CdS nanoplatelets显示文摘在这份报纸,我们证明为胶体的 CdSe/CdS nanoplatelets,矩形的形状导致排放不对称现象,以极化和排放模式。测极化和排放模式分析被联合在涉及 nanoplatelet 排放的转变偶极子的取向上提供信息。为矩形的 nanoplatelets,排放被极化,排放模式是各向异性的,这被显示出,而他们仍然保持为方形的 nanoplatelets 非极化、各向同性。这能被矩形的血小板的伸长的形状导致的绝缘的天线效果适当地描述。 | Fu Fengt Loan Thu Nguyen Michel Nasilowski Brice Nadal Benoit Dubertret Laurent Coolent Agnes Maitre | 2018 | Nano Research2018，11，7： | 0 |
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