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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | 细粒棘球蚴重组抗原B的表达提取及其血清学检测初探显示文摘用基因工程技术制备出的细粒棘球绦虫重组抗原 B( r Ag B)表达载体 ,经诱导表达、亲和层析纯化获得具生物活性的重组蛋白质 r Ag B,用 Western- Blot法检测病人血清。结果显示 r Ag B敏感性为 91.6% ( 4 4/48) ,特异性为 93 .8% ( 3 0 /3 2 ) ,其中 10例泡球蚴 ( AE)病人及 10例肿瘤病人血清均无交叉反应。说明 r Ag B具有较高的敏感性及特异性 ,可用于包虫病的常规血清学诊断 ,r Ag B在宿主菌 JM10 9内稳定表达 ,因此可在实验室内大量制备用于血清学诊断的 r Ag B。 | 卢晓梅 温浩 Alison FS 付玉才 Craig PS | 2001 | 地方病通报2001，16，3： | 9 |
| 3 | Hepatic ischemic preconditioning increases portal vein flow in experimental liver ischemia reperfusion injury显示文摘BACKGROUND: Ischemic preconditioning(IPC) has been shown to decrease liver injury and to increase hepatic microvascular perfusion after liver ischemia reperfusion. This study aimed to evaluate the effects of IPC on hemodynamics of the portal venous system. METHODS: Thirty-two rats were randomized into two groups: IPC group and control group. The rats of the IPC group underwent IPC by 10 minutes of liver ischemia followed by 10 minutes of reperfusion before liver ischemia, and the rats of the control group were subjected to 60 minutes of partial liver ischemia. Non-ischemic lobes were resected immediately after reperfusion. The animals were studied at 4 hours and 12 hours after reperfusion. Mean arterial pressure, heart rate, portal vein flow and pressure were analyzed. Blood was collected for the determination of the levels of aspartate aminotransferase, alanine aminotransferase, calcium, lactate, pH, bicarbonate, and base excess. RESULTS: IPC increased the mean portal vein flow at 4 hours and 12 hours after reperfusion. IPC recovered 78% of the meanportal vein flow at 12 hours after reperfusion. IPC decreased the levels of aspartate aminotransferase, alanine aminotransferase and lactate, and increased the levels of ionized calcium, bicarbonate and base excess at 12 hours after reperfusion. CONCLUSIONS: This study demonstrated that IPC increases portal vein flow and enhances hepatoprotective effects in liver ischemia reperfusion. The better recovery of portal vein flow after IPC may be correlated with the lower levels of transaminases and with the better metabolic profile. | Estela RR Figueira Joel A Rocha-Filho Mauro Nakatani Marcelo FS Buto Eduardo R Tatebe Vitor O Andre Ivan Cecconello Luiz AC D'Albuquerque | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 6 |
| 4 | 在现实生活中,有与无人值守时血压测量的差异显示文摘关于收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的研究结果 是否具有普遍性的争论,引起了人们对无人值守诊室血压测量技术相当大的兴趣。现实世界中,与在熟悉的诊室里进行的传统血压测量方法相比,无人值守的血压测量值是否更低,尚无定论。 | 叶超毅 叶鹏 Bauer F Seibert FS Rohn B Bauer KAR Rolshoven E Babel N Westhoff TH | 2018 | 中华高血压杂志2018，26，3： | 5 |
| 5 | Survival factors after resection of small hepatocellular carcinoma显示文摘Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC. | Departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and General Surgery ( Liang TB and Zheng SS) , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 5 |
| 6 | 保护性免疫大鼠结支睾吸虫后吡喹酮化疗效果显示文摘目的 研究吡喹酮与宿主保护性对华支睾吸虫感染的协同作用。方法 用粗成虫抗原9AWAg)和排泄分泌抗的(ESAg)免疫大鼠或感染20条华支睾吸虫囊蚴获得保护性免疫,用50俱结支睾吸虫囊蚴感染大鼠,用亚致死量吡喹酮(50mg/kg)治疗,以回收虫体数观察疗效。统计学上显著性差异用PC-SAS系统的ANOVA和Nparlway Kruskal-Wallis检验法。结果 (1)在对照组,ESAg免疫接 | Quan,FS Lee,JS | 2000 | 中国寄生虫学与寄生虫病杂志2000，18，2： | 3 |
| 7 | 慢性阻塞性肺疾病急性加重住院患者的痰微生物族谱与其一年病死率相关显示文摘背景呼吸系统中的微生态失衡可促进气道炎症、损害局部免疫力,在慢性阻塞性肺疾病(慢阻肺)急性加重的发病机制中发挥重要作用。本研究分析了住院慢阻肺急性加重患者的痰微生物族谱与随访后该群患者的1年病死率的相关性。方法本研究收集慢阻肺急性加重住院患者的痰液样本,通过16S rRNA基因测序对微生物族谱进行了评价,最后根据患者1年的生存情况进行分析,应用Cox比例风险回归模型获得相关的风险比(HR)。 | Leitao Filho FS Alotaihi NM Ngan D 张明强 牟向东 | 2019 | 中华结核和呼吸杂志2019，42，4： | 3 |
| 8 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 9 | Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study显示文摘We evaluated the efficacy and safety of gamma knife stereotactic radiosurgery(GKSR)followed by bevacizumab combined withchemotherapy in 11 patients with recurrent glioblastoma multiforme who experienced tumor progression despite aggressive | Park KJ Kano H Iyer A Liu X Niranjan A Flickinger JC Lieberman FS Lunsford LD Kondziolka D | 2012 | 中国神经肿瘤杂志2012，10，4： | 3 |
| 10 | 核盘菌子囊孢子对向日葵叶部的侵染显示文摘 | Sedu.,FS 汪景宽 | 1989 | 国外农学(向日葵)1989，，3： | 2 |
| 11 | A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUM显示文摘A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUMFangShengWANG;HuiCAI;ZaiXinJING(UniversityofAgricultureandAnimalScience.P... | Wang, FS Cai, H Jing, ZX Yang, JS Zhang, YM | 1995 | Chinese Chemical Letters1995，6，12： | 2 |
| 12 | Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection显示文摘 | Arana FS Parkinson JA | | The Journal of Neuroscience0，22，： | 2 |
| 13 | 全髋关节置换术假体周围感染的处理(一)显示文摘全髋关节置换术(THA)是骨科最常见的手术之一。尽管初次THA术后深部感染率相对低,但其带来的经济负担、残疾、甚至死亡具有潜在的破坏性。由于有越来越多的老年患者需要行关节成形术,感染的预防和应该最优化治疗,以减少患者与医疗系统直接和间接的代价。 | MTS Sukeik FS Haddad 李之琛 张妹江 | 2011 | 中华关节外科杂志(电子版)2011，5，4： | 2 |
| 14 | High-resolution source imaging in mesiotemporal lobe epilepsy: a comparison between MEG and simultaneous EEG显示文摘 | Leijten FS Huiskamp GJ Hilgersom I | 2003 | J Clin Neurophysiol2003，20，4： | 2 |
| 15 | 三维肛管直肠超声在肛管直肠疾病中的应用显示文摘肛管直肠超声可用来诊断多种肛管直肠良、恶性疾病。近几年来.该技术取得了长足进步.其应用360度旋转高频(6.16MHZ)探头(焦距2.8~6.2cm),无需转动探头便可获得高清晰的肛管直肠三维结构图。位于探头远端的换能晶片向近端边旋转边移动,持续55S.可获得长约6cm的图像。这个图像是将连续的0.2mm层厚轴向切面通过容积再现技术合成的高清晰的三维数字立体图像。其拥有多个视角(同时4~6个视野).可同时观察多个解剖平面.进行低亮度、高对比度调整,可形成半透明暗腔。 | Murad Regadas SM Pinheiro Regadas FS 王颢(译) 鄂继福(译) 傅传刚(校) | 2009 | 中华胃肠外科杂志2009，12，6： | 2 |
| 16 | Physiological and radiographic assessment during the development of pulmonary radiation fibrosis 显示文摘 | Prato FS Kurdyak R Saibil EA | 1977 | Radiology1977，122，2： | 1 |
| 17 | Helical CT in the evaluation of the acute abdomen 显示文摘 | Gore RM Miller FH Pereles FS | 2000 | AJR Am J Roentgenol2000，174，4： | 1 |
| 18 | Potent mimicry of infibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin显示文摘 | Schmitmeier S Markland FS Schonthal AH | 2005 | Neurosurgery2005，57，1： | 1 |
| 19 | Clinical outcome with half-dose depot triptorelin is the same as reduced-dose daily buserelin in a long protocol of controlled ovarian stimulation for ICSI/embryo transfer:a randomized double-blind clinical trial(NCT00461916)显示文摘 | Safdarian L Mohammadi FS Alleyassin A | 2007 | Hum Reprod2007，22，9： | 1 |
| 20 | INK4a gene expression and methylation in primary breast cancer: overexpression of p161NK4a messenger RNA is a marker of poor prognosis 显示文摘 | Hui R Macmillan RD Kenny FS | 2000 | Clin cancer Res2000，6，7： | 1 |
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