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| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | Carcinogenic potential of duodenal reflux juice from patients with long-standing postgastrectomy显示文摘AIM To determine, whether study on thecarcinogenic potential of reflux juice frompatients with remote gastrectomy could clarifythe inherent relationship between duodenalreflux and gastric stump cancer.METHODS A total of 37 reflux juice samples(13 Billroth T, 24 Billroth Ⅱ ) were employed inthe present study. A two- stage transformationassay using BALB/c 3T3 cells was carried out totest the initiating or promoting activity of thesesamples.RESULTS Two of 18 (11.1%) reflux samplesexerted initiating activities, whereas 9/19(47.4%) samples enhanced the MNNG-initiafingcell transformation, suggesting the duodenalreflux juice might more frequently possess thetumor-promoter activity (P = 0. 029). In addition,there was no difference in initiating activities ofthe samples irrespective of surgical procedures(P=0.488), while Billroth Ⅱ samples exhibitedstronger tumor-promoter activity than Billroth Ⅰsamples (P = 0.027). Furthermore, the promoteractivities were well correlated with thehistological changes of the stomas (rs = 0.625,P = 0.004), but neither their cytotoxicities norinitiating activities had this correlation( Probabilities were 0.523 and 0.085,respectively).CONCLUSION The duodenal reflux juice frompatients with remote postgastrectomy did havecarcinogenic potential, and suggested thattumor-promoting activity should principallyaccount for the high incidence of gastric cancerin gastrectomy patients. In contrast, it isdifficult to explain the high stump-cancerincidence with the 'N-nitroso compounds'theory-a popular theory for the intact stomachcarcinogenesis, and it seemed to be justified tofocus chemoprevention of this cancer on thetumor-promoting potential of reflux juice. | Zhe Fu Ma~1 Zhong Yu Wang~1 Jun Ran Zhang~2 Peng Gong~1 Hai Long Chen~1 ~1Departrnent of General Surgery,First Hospital,Dalian Medical University,Dalian 116011,China ~2Department of Radiation Oncology,Massachusetts General Hospital and Harvard Medical School,Charlestown,MA 02129,USADr.Zhe Fu Ma graduated from Shanxi Medical College in 1993,nowPh.D.,M.D.in Department of Surgery,Dalian Medical University,majoring gastroenteric cancer,having 4 papers published.Correspondence to:Dr.Zhe Fu Ma.Department of General Surgery,First Hospital,Dalian Medical University,Dalian 116011,China Tel.0086-411-4720334 | 2001 | World Journal of Gastroenterology2001，7，3： | 9 |
| 3 | 1993年SNA修订问题综述——1993年SNA修订问题研究系列之一显示文摘为了积极参与1993年SNA的修订工作,使新的国民经济核算国际标准反映中国经济发展的实际情况,国家统计局国民经济核算司成立了1993年SNA修订问题研究小组。该研究小组的任务是,跟踪联合国1993年SNA修订工作情况,研究修订问题,提出修订建议,向国内同行介绍有关1993年SNA修订的进展情况和修订内容。从本期起,《统计研究》将连载该研究小组的系列文章。本期刊出该研究系列的第一篇。 | 国民经济核算司1993年SNA修订问题研究小组 许宪春 赵红 | 2006 | 统计研究2006，23，3： | 7 |
| 4 | Studies on the solid state reactions of coordination conpounds——XLⅤⅢ.The effect of KSCN on the thermal decomposition of cobalt(Ⅲ)-ammine complexes显示文摘The evolved gaseous analysis (EGA),infrared spectra,and XRD have been appliedto the study of solid state reactions of KSCN with five cobalt(Ⅲ)-ammine complexes:[Co-(NH3)5N3]Cl2,[Co(NH3)5(NO2)]Cl2,[Co(NH3)5(H2O)]Cl3,[Co(NH3)5Cl]Cl2,and [Co(NH3)6]Cl3in a hydrogen atmosphere.It is found that the existence of KSCN shifts the thermal decom-position of these complexes to a lower temperature.The corresponding peak temperatures arenear 140℃.The effect of KSCN is discussed and kinetic parameters of deammine reactionsare calculated. | ZHENG,Li-Min XIN,Xin-Quan Coordination Chemistry Institute,Nanjing University,Nanjing 210008 Part XLVⅡ of this series:Chin.J.Chem.,11,21(1993) | 1993 | Chinese Journal of Chemistry1993，11，3： | 7 |
| 5 | 有关土地及土地改良的处理方法——1993 SNA修订问题研究系列之五显示文摘This paper discusses the issue of different asset classification of land and land improvement and provides various recommendations. | 国民经济核算司1993年SNA修订问题研究小组 许宪春 王益烜 | 2006 | 统计研究2006，23，7： | 5 |
| 6 | 呆坏账核算的修订及其对我国核算影响的研究——1993年SNA修订问题研究系列之七显示文摘There are some problems about the treatment of Non-performing loans(NPLs) in the current 1993 SNA. Four kinds of measurements are provided on loan valuation and four options are consequently given a by special working group on NPLs of the IMF. Through discussion,it is determined that loans are remained to be measured at nominal value in the main accounts.Meanwhile,the fair value of loans is recorded on the asset side of balance sheets.In regards to the impact on FISIM,option 1 is preferable, i.e. continue to estimate FISIM on NPLs and allocate it to the corresponding borrowers.The unpaid FISIM is recorded in the accounts in such a way as to increment principal outstanding. | 国民经济核算司1993年SNA修订问题研究小组 许宪春 王绍辉 | 2006 | 统计研究2006，23，9： | 2 |
| 7 | Studies on polyhaloalkanes Ⅱ.A facile method for mono-fluorination of α,ω-dihaloperfluoroalkanes显示文摘A faeilo monofluorination of α,ω-dihaloporfluoroalkanes was achieved by the reactionof them with antimony trifluoride and chlorine in anhydrous antimony pentachloride when mono-fluorinated products wero removed immediately after their formation from the reaction mixture byfractionation.The reaction conditions were also investigated. | HUANG,Bing-Nan PRESCHER,Dietrich Shanghai Institute of Organic Chemistry,Chinese Aeademy of Sciences,Shanghai 200032 Part Ⅰ of this series:Chin.J.Chem.,11,169(1993).On leave from Central Institute of Organic Chemistry,Berlin 0-1199,Germany. | 1993 | Chinese Journal of Chemistry1993，11，2： | 2 |
| 8 | 高通货膨胀条件下对利息的核算——1993SNA修订问题研究系列之六显示文摘Under conditions of high inflation,it is necessary to readjust the measurement and recording for interest.The 1993 SNA suggests apply the concept of real interest and a parallel treatment of interest.However,Andre Vanoli and Peter Hill,two accounting specialists,propose different recommendations on this issue.This paper conducts a comparative analysis over these recommendations. | 国民经济核算司1993年SNA修订问题研究小组 许宪春 王绍辉 | 2006 | 统计研究2006，23，8： | 2 |
| 9 | 关于矿藏勘探问题——1993SNA修订问题研究系列之二显示文摘Focusing on the problem of repeated calculation of mineral resource exploration and mineral resource reserves, the paper discusses the issues of definition and classification of mineral resource exploration, and calculation of fixed capital consumption. | 国民经济核算司1993年SNA修订问题研究小组 许宪春 王益 | 2006 | 统计研究2006，23，4： | 2 |
| 10 | The rise of costal and marine tourism显示文摘 | Miller M 1993 | 1993 | Ocean & costal Management1993，20，3： | 1 |
| 11 | Aroma glycosides from Hovenia dulsis显示文摘 | Yoshikawa K Nagai M Wakabayashi M 1993 | 1993 | Phytochemistry1993，34，5： | 1 |
| 12 | Building a Learning Organization显示文摘 | Garvin(1993) | 1971 | Harvard Business Review1971，，4： | 1 |
| 13 | Effect of water table management practices on transport of nitrate-nitrogen to shallow groundwater显示文摘 | Kalita P K Kanwar R S 1993 | 1993 | T ASAE1993，36，： | 1 |
| 14 | APIC guidelines for infection control praetiee:APIC guidelines for handwashing and hand antisepsis in healthcare settings 显示文摘 | Lason EL and the 1992 1993 and 1994 APIC Guidelines Committee | 1995 | AM J infect Control1995，23，： | 1 |
| 15 | Photochemistry on nonreactive and reactive(semiconductor) surfaces显示文摘 | Kamat P V 1993 | 1993 | Chem Rev1993，93，： | 1 |
| 16 | Hydrogen production by steam reforming glucose in supercritical water显示文摘 | Yu D Aihara M Antal Jr M J 1993 | 1993 | Energy Fuels1993，7，： | 1 |
| 17 | Does the alternative pathway ameliorate chilling injury in sensitive plant tissues显示文摘 | Purvis AC Shewfelt RL 1993 | 1993 | Physiol Plant1993，88，： | 1 |
| 18 | Degradation of chlorobenzoates in soil slurry by special organisms显示文摘 | Brunsbach F R Reineke W 1993 | 1993 | Appl Microbiol Biotechnol1993，39，： | 1 |
| 19 | Interaction of fungi with toxic metals显示文摘 | 1993 | 1993 | New Phytol1993，124，： | 1 |
| 20 | The importance of being 'only': testing the neo-Gricean versus neo-entailment paradigms显示文摘 | Atlas Jay (1993) | 1993 | Journal of Semantics1993，10，： | 1 |
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