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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 3 | Interferon - alpha enhances TRAIL - mediated apoptosis by up - regulating caspase - 8 transcription in human hepatoma cells 显示文摘 | Liedtke C Groger N Manns MP | 2006 | J Hepatol2006，44，2： | 1 |
| 4 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 5 | Steady - state levels of aquaporinl mRNA expression are increased in idiopathic polyhydramnios 显示文摘 | Mann SE Dvorak N Gilbert H | 2006 | Am J Obstet Gynecol2006，194，： | 1 |
| 6 | On the performance and resonant frequency of electromagnetic induction energy harvesters显示文摘 | MANN B P SIMS N D | 2010 | Journal of Sound and Vibration2010，329，9： | 1 |
| 7 | Assessing the effectiveness and opti-malstructure of trauma systems: a consensus amongexperts显示文摘 | Mann N | 1999 | J Trauma1999，47，3： | 1 |
| 8 | Aniotension Ⅱ induces tumor necrosis factor biosythesis in the adult mammalian heartthrough a proteinkinase C - dependent pathway显示文摘 | Kalra D Sivasubramannicm N Mann DL | 2002 | Circulation2002，105，： | 1 |
| 9 | Fenofibrate attenuates tubulointerstitial fibrosis and inflammation through suppression of nuclear factor-kappaB and transforming growth factor-beta1/Smad3 in diabetic nephropathy显示文摘 | Li L Emmett N Mann D | | 0，，： | 1 |
| 10 | Vapor-liq- uid equilibrium data for propylene-propane system 显示文摘 | MANN A N PARDEE W A SMYTH R W | 1963 | J Chem Eng Data1963，8，4： | 1 |
| 11 | Bioinorganic clays: synthesis and characterization of amino and polyamino acid intercalated layered double hydroxides 显示文摘 | WHILTON N T VICKERS P J MANN S | 1997 | J Mater Chem1997，7，8： | 1 |
| 12 | Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during α-interferon treatment显示文摘 | Georgios N Dalekos Heiner Wedemeyer Petra Obermayer-Straub Anne Kayser Ayse Barut Hannah Frank Michael P Manns | 1999 | Journal of Hepatology1999，，3： | 1 |
| 13 | The VISTA science archive 显示文摘 | Cross N J G Collins R S Mann R G | 2012 | Astronomy & Astrophysics2012，，： | 1 |
| 14 | Cesium sorption from concentrated acidic tank wastes using ammonium mo- lybdophosphate-polyacrylonitrile composite sorbents显示文摘 | Todd T A Mann N R Traner T J | 2002 | J Radioanal Nucl Chem2002，254，1： | 1 |
| 15 | Structure ,function andtissue forms of the globular domain of the C- terminal globulardomain of collagen X Ⅷ containing the angiogenesis inhibitorendostatin显示文摘 | Fukai N Mann K | 1998 | Embo J1998，17，15： | 1 |
| 16 | Energy harvesting from the nonlinear oscillations of magnetic levitation显示文摘 | MANN B P SIMS N D | 2009 | Journal of Sound and Vibration2009，319，12： | 1 |
| 17 | Structure and significance of C30 4-methyl stranes in lacustrine shales and oils显示文摘 | Goodwin N S Mann A L Patience R L | 1988 | Organic Geochemistry1988，12，5： | 1 |
| 18 | Malignant hepatic tumours in children:incidence,clinical features and aetiology显示文摘 | Mann JR Kasthuri N Raafat F | 1990 | Paediatr Perinat Epidemiol1990，4，3： | 1 |
| 19 | Diet, nutrition and the prevention of type 2 diabetes显示文摘 | STEYN N P MANN J BENNETT P H | 2004 | Public Health Nutr2004，7，： | 1 |
| 20 | Nucleus isthmi,pars semilunaris as a key component of the tectofugal visual system in pigeons显示文摘 | Hellmann B Manns M Güntürkün O | 2001 | J Comp Neurol2001，436，： | 1 |
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