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| 1 | Liver fat content determined by magnetic resonance imaging and spectroscopy显示文摘Hepatic steatosis as the most prevalent liver disorder can either be related to alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD). In both conditions, hepatocytes excessively accumulate fatcontaining vacuoles within their cytoplasm, which is the key histological feature. In contrast to ALD, NAFLD is commonly associated with metabolic syndrome, obesity and insulin resistance. To determine increased liver fat content, liver biopsy is currently considered the gold standard. Besides the invasive technique, various other non-invasive techniques have been developed, such as ultrasound, computed tomography (CT), magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) based methods. Among these techniques, ultrasound and CT provide only qualitative information about hepatic steatosis, whereas MRS-or MRI-based methods are able to determine even small amounts of fat accurately. These non-invasive magnetic resonance techniques have already proven their great potential, especially in longitudinal and cross-sectional studies regarding various metabolic conditions and medical treatment regimens. In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations. | Fabian Springer Jürgen Machann Claus D Claussen Fritz Schick Nina F Schwenzer | 2010 | World Journal of Gastroenterology2010，16，13： | 19 |
| 2 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Fractionation of sulfur and oxygen isotopes in sulfate by soil sorption 显示文摘 | van Stempvoort D R Reardon E J Fritz P | 1990 | Geochim Cosmochim Acta1990，54，10： | 1 |
| 5 | Conservation of Bmp2 post-transcriptional regulatory mechanisms 显示文摘 | Fritz D T Liu D Xu J | 2004 | J Biol Chem2004，279，48： | 1 |
| 6 | Phenetic Diversity of Alkaliphilic Bacillus Strains:Proposal for Nine New Species显示文摘 | Nielsen P Fritze D Priest F G | 1995 | Microbiology1995，141，： | 1 |
| 7 | Aerial application methods for increasing spray deposition on wheat heads 显示文摘 | Fritz B K Hoffmann W C Martin D E | 2007 | Applied Engineering in Agriculture2007，23，6： | 1 |
| 8 | Phenetic diversity of alkaliphilic Bacillus strains: proposal for nine new species显示文摘 | NieLsen P Fritze D Priest FG | 1995 | Microbiology1995，141，7： | 1 |
| 9 | The isotopic composition of secondary dolomites显示文摘 | Fritz P smith D G W | 1970 | Geochimica et Cosmochimica Acta1970，34，： | 1 |
| 10 | ERCP is s',ffe and ef- fective in patients 80 years of age and older compared with youn- ger patients显示文摘 | Fritz E0 Kirchgatterer A Hubner D | 2006 | Gastrointest Endosc2006，64，6： | 1 |
| 11 | Experimental and observational studiesof patch choice at different scales by the crab spider Misumenavatia显示文摘 | Morse D H Fritz R S | 1982 | Ecology1982，63，1： | 1 |
| 12 | Genome - 'side reprogramming of primary and secondary metabollsm, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen 显示文摘 | Scheibl W R Morcuende R Czechowshi T Fritz C Osuna D | 2004 | Plant Physiology2004，136，： | 1 |
| 13 | Accuracy of the clinical examina- tion to predict radiographic instability of the lumbar spine显示文摘 | Fritz J M Piva S R Childs J D | 2005 | Eur Spine J2005，14，8： | 1 |
| 14 | A web-based multi-perspective decision support system for information security planning显示文摘 | E1-Gayar O F Fritz B D | 2010 | Decision Support Systems2010，50，1： | 1 |
| 15 | A wet/wet differential pressure sensor for measuring vertical hydraulic gradient 显示文摘 | FRITZ B C MACKLEY R D | 2010 | Ground Water2010，48，1： | 1 |
| 16 | Endoscopic retrograde cholangio-pancreatograph (ERCP)in patients 80 years of age and older:safe and effective显示文摘 | Fritz E Kirchgatterer A Hubner D | 2004 | Gastrointest Endosc2004，59，： | 1 |
| 17 | Sensitization and Stabiliza- tion of Type 409 Ferritie Stainless Steel 显示文摘 | Fritz James D Franson Ivan A | 1997 | Materials Selec- tion and Design MP1997，36，： | 1 |
| 18 | ERCP is safe and effective in patients 80 years of age and older compared with younger patients显示文摘 | Fritz E Kirchqatterer A Hubner D | 2006 | Gastrointest Endosc2006，64，6： | 1 |
| 19 | Distribution of the product confidence limits for the indirect effect: Program prodclin 显示文摘 | MACKINNON D P FRITZ M S WILLIAMS J | 2007 | Behavior Research Methods2007，39，3： | 1 |
| 20 | Chloride stress corrosion cracking resistance of 6% Mo stainless steel alloy (UNS N08367)显示文摘 | Fritz J D Gerlock R J | 2001 | Desalination2001，135，13： | 1 |
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