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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Aerial application methods for increasing spray deposition on wheat heads 显示文摘 | Fritz B K Hoffmann W C Martin D E | 2007 | Applied Engineering in Agriculture2007，23，6： | 1 |
| 3 | miR - 142~ interferes with ERK5 signaling, and abrogates prostate cancer progression in mice 显示文摘 | Clap6 C Fritz V Henriquet C | 2009 | PLoS One2009，4，10： | 1 |
| 4 | Avermectiu Bla irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance显示文摘 | Fritz L C Wang C C Corio A | 1979 | Proc Natl and Acad Science USA1979，76，： | 1 |
| 5 | Coronary anatomy and left ventricular function in the first 12 hours of acute myocardial infarction显示文摘 | STADIUS ML MAUNARD C FRITZ JR | 1985 | Circulation1985，72，2： | 1 |
| 6 | Cytogenetic analysis of culture failures by comparative genomic hybridization (CGH)-re-evaluation of chromosome aberration rates in early spontaneous abortions 显示文摘 | Fritz B Hallermann C Olert J | 2001 | Eur J Hum Genet2001，9，7： | 1 |
| 7 | HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells显示文摘 | Wild CA Bergmann C Fritz G | 2012 | Int Immunol2012，24，8： | 1 |
| 8 | Anaerobic oxidization ofmethane in a minerotrophic peatland : enrichment of nitrite-dependent methane-oxidizing bacteria 显示文摘 | ZHU Baoli VAN DIJK G FRITZ C | 2012 | Applied andEnvironmental Microbiology2012，78，24： | 1 |
| 9 | Avermectin B1a irre-versibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resis-tance,Proc,Natl,and Acad显示文摘 | Fritz L C Wang C C Gorio A | 1979 | Sci U S A1979，76，： | 1 |
| 10 | Soluble interleukin-2 receptors are released from activated human lymphoid cells in vitro显示文摘 | Rubin L A Kurman C C Fritz M E | 1985 | J Immunol1985，135，5： | 1 |
| 11 | On fast decoupled continuation power flows 显示文摘 | Mohn Fritz Walter de Souza A C Z | 2002 | Electric Power Systems Research2002，63，： | 1 |
| 12 | Inheritance and Mechanisms of Resistance to Anilinopyrimidine Fungicides in Botrytis Cinerea显示文摘 | CHAPELAND F FRITZ R LANEN C | 1999 | Pestic Biochem Physiol1999，64，： | 1 |
| 13 | Genome - 'side reprogramming of primary and secondary metabollsm, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen 显示文摘 | Scheibl W R Morcuende R Czechowshi T Fritz C Osuna D | 2004 | Plant Physiology2004，136，： | 1 |
| 14 | S - 100 proteins:structure, functions and pathology 显示文摘 | Heizmann C W Fritz G Schafer B W | 2002 | Front Biosci2002，7，： | 1 |
| 15 | Critical transitions in the biofabrication of abalone shells and flat pearls 显示文摘 | Zaremba C M Belcher A M Fritz M | 1996 | Chem Mater1996，8，： | 1 |
| 16 | Separation and quantitative determination of the yttrium group lanthanides by gas- liquid chromatography 显示文摘 | Burgett C A Fritz J S | 1972 | Analytical Chemistry1972，44，11： | 1 |
| 17 | Evaluation of a proposed drift reduction technology high-speed wind tunnel testing protocol 显示文摘 | Hoffmann W C Fritz B K Lan Y | 2009 | Journal of ASTM International2009，6，4： | 1 |
| 18 | A wet/wet differential pressure sensor for measuring vertical hydraulic gradient 显示文摘 | FRITZ B C MACKLEY R D | 2010 | Ground Water2010，48，1： | 1 |
| 19 | Reha-bilitation of a heavilymodified river section of the Danube in Vienna (Austria):biological assessment of landscape linkages on different scales显示文摘 | Andreas C Fritz S Herwig W | | 0，，： | 1 |
| 20 | Active pedestrian safety by automatic braking and evasive steering 显示文摘 | Keller C Dang T Fritz H | 2011 | Intelligent Transpor- tation Systems2011，12，4： | 1 |
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