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| 1 | Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients显示文摘AIM To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease(IBD).METHODS IBD patients were recruited from nine hospitals in the southeastern and western regions of Norway to participate in a multicenter cross-sectional study lasting from March 2013 to April 2014. Data were collected by interviews, from medical records and laboratory tests. The Fatigue Questionnaire(FQ) was used to measure fatigue. Linear and logistic regression models were applied to explore the possible association between vitamin D deficiency and total fatigue scores and chronic fatigue, respectively. The analyses were adjusted for age, gender, disease activity, depressive symptoms and sleep disturbance.RESULTS In total, 405 patients were included in the analyses, of which 227(56%) had Crohn's disease(CD) and 178(44%) had ulcerative colitis(UC). Vitamin D deficiency(< 50 nmol/L) was present in half(203/405) of the patients. Chronic fatigue was reported by 116(29%) of all included patients with substantial fatigue reported by 194(48%). Vitamin D levels were neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores in patients with UC and CD, but not with increased CRP or fecal calprotectin. In UC patients, female gender was associated with fatigue in the univariate analysis, but no such difference was found when adjusted for elevated disease activity scores. Sleep disturbance and more depressive symptoms were associated with total fatigue scores in both UC and CD patients, but with chronic fatigue only in CD patients.CONCLUSION In this study, no significant association between fatigue and vitamin D deficiency in IBD patients was revealed. | Svein Oskar Frigstad Marte Lie Hoivik Jorgen Jahnsen Milada Cvancarova Tore Grimstad Ingrid Prytz Berset Gert Huppertz-Hauss Oistein Hovde Tomm Bernklev Bjorn Moum Lars-Petter Jelsness-Jorgensen | 2018 | World Journal of Gastroenterology2018，24，29： | 2 |
| 2 | Improved contrast to tissue ratio at higher harmonics显示文摘 | Bouakaz A Frigstad S Cate FJT | 2002 | Ultrasonics2002，40，18： | 1 |
| 3 | Accurate and reproducible measurement of left ventricular volume and ejection fraction by contrast echocardiography:a comparison with magnetic resonance imaging显示文摘 | Malm S Frigstad S Sagberg E | 2004 | J Am Coll Cardiol2004，44，5： | 1 |
| 4 | Accurate and reproducible measurement of leftventricular volume and ejection fraction by contrast echocardiography:a comparisonwith magnetic resonance imaging显示文摘 | Malm S Frigstad S Sagberg E | 2004 | J Am Coll Cardiol2004，44，5： | 1 |
| 5 | Accurate and reproducible measurement of left ventricular volume and ejection fraction by contrast echocardiography: a comparison with magnetic resonance imaging显示文摘 | Mahn S Frigstad S Sagberg E | 2004 | J Am Coll Cardiol2004，44，5： | 1 |
| 6 | Quantitative adenosine real-time myocardial contrast echocardiography for detection of angiographically significant coronary artery disease显示文摘 | Malm S Frigstad S Torp H | 2006 | J AM Soc Echocardiogr2006，19，4： | 1 |
| 7 | Quantification of resting my- ocardial blood flow velocity in normal humans using real-time con- trast echoeardiography:A feasibility study显示文摘 | Maim S Frigstad S Helland F | 2005 | Cardiovasc ultrasound2005，16，3： | 1 |
| 8 | Accurate and reproducible measurement of left ventricular volume and ejection fraction by contrast echocardiography:a comparison with magnetic resonance irrtaging显示文摘 | Maim S Frigstad S Sagberg E et aI | 2004 | J Am Coil Cardiol2004，44，5： | 1 |
| 9 | An in Vitro Assessment of the Fflow Characteristics of Spiral-ridged and Smooth-walled JJ Ureteric Stents显示文摘 | Stoller M L Schwartz B F Frigstad J R | 2000 | BJU lnt2000，，85： | 1 |
| 10 | Accurate and reproduci- ble n'Leasurcment of left ventricular volume and ejection fraction by contrast echocardiography: a comparison with magnetic reso- nance imaging显示文摘 | Maim S Frigstad S Sagberg E | 2004 | J Am Coil Cardiol2004，44，： | 1 |
| 11 | Super harmonic imaging: a new imaging technique for improved contrast detection 显示文摘 | Bouzkaz A Frigstad S Ten Cate F J | 2002 | Uhrasoundin Med Biol2002，28，1： | 1 |
| 12 | Super harmonic imaging: a new imaging technique for improved contrast detection显示文摘 | BOUZKAZ A FRIGSTAD S TEN CATE F J | 2002 | Ultrasound in Med & Biol2002，28，1： | 1 |
| 13 | Accurate and reproducible t of left ventricular volume and ejection fraction by con- trast echocardiography:a comparison with magnetic resonance ima- ging显示文摘 | Maim S Frigstad S Sagberg E | 2004 | J Am Coil Cardio12004，44，5： | 1 |
| 14 | Accurate and reproducible measurement of left ventricular volume and ejection fraction by contrast echocardiography: a comparison with magnetic resonance imaging 显示文摘 | Malta S Frigstad S Sagberg E | 2004 | J Am Coll Cardiol2004，44，5： | 1 |
| 15 | Super harmonic imaging:a new imaging technique for improved contrast detection显示文摘 | Bouakaz A Frigstad S Ten CFJ | 2002 | Ultrasound in Med & Biol2002，28，1： | 1 |
| 16 | Accurate and reproduciblemeasurement of left ventricular volume and ejection fraction by contrastechocardiography: a comparison with magnetic resonance imaging 显示文摘 | Malm S Frigstad S Sagberg E | 2004 | J AmColl Cardiol2004，44，5： | 1 |
| 17 | Accurate and reproducible measurement of left ventricular volume and ejection fraction by contrast echocardiography:a comparison with magnetic resonance imaging显示文摘 | Maim S Frigstad S Sagberg E | | 0，，05： | 1 |
| 18 | Accurate and reproducible measurement of left ventricular volume and ejection fraction by contrast echocardiography: a comparison with magnetic resonance imaging显示文摘 | Maim S Frigstad S Sagberg E | 2004 | J Am Coil Cardiol2004，44，5： | 1 |
| 19 | Accurate and reproduciblemeasurement of left ventricular volume and ejection fraction bycontrast echocardiography : a comparison with magnetic resonanceimaging显示文摘 | Malm S Frigstad S Sagberg E | 2004 | J Am Coll Cardiol2004，44，： | 1 |
| 20 | Accurate and reproducible measurement of left ventricular volume and ejection fraction by contrast echocardiography显示文摘 | Siri Malm Sigmund Frigstad Einar Sagberg Henrik Larsson Terje Skjaerpe | 2004 | Journal of the American College of Cardiology2004，，5： | 1 |
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