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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Prediction and prevention of ischemie placental disease显示文摘 | Friedman AM Cleary KL | 2014 | Semin Perinatol2014，38，3： | 1 |
| 3 | Atypical complications encountered with epicardial electrophysiological procedm'es 显示文摘 | Killu AM Friedman PA Mulpuru SK et at | 2013 | Heart Rhythm2013，10，： | 1 |
| 4 | Prediction and prevention of ischemic placental disease显示文摘 | Friedman AM Cleary KL | 2014 | Semin Perinatol2014，38，3： | 1 |
| 5 | Ocular blood flow velocity in age-related macular degeneration显示文摘 | Friedman E Krupsky S Lane AM | 1995 | Ophthalmology1995，102，4： | 1 |
| 6 | Preoperative screening of contact lens wearers before refractive surgery显示文摘 | Budak K Hamed AM Friedman NJ | 1999 | J Refract Surg1999，25，8： | 1 |
| 7 | Predictors and outcomes of 'super-response' to cardiac resynchronization therapy显示文摘 | Killu AM Grupper A Friedman PA | 2014 | J Card Fail2014，20，6： | 1 |
| 8 | Predictors and outcomes of 'super-response' to cardiac resynchronization therapy 显示文摘 | Killu AM Grupper A Friedman PA | 2014 | J Card Fail2014，20，6： | 1 |
| 9 | Global right atrial mapping of human atrial flutter:the presence of posteromedial(sinus venosa region)functional block and double potentials显示文摘 | Friedman PA Luria D Fenton AM | 2001 | Circulation2001，101，： | 1 |
| 10 | Prediction and prevention of ischemic placental disease显示文摘 | Friedman AM Cleary KL | 2014 | Semin Perinatol2014，58，3： | 1 |
| 11 | Predictors and outcomes of ' superre- sponse' to cardiac resynchronization therapy 显示文摘 | Killu AM Grupper A Friedman PA | 2014 | J Card Fail2014，20，： | 1 |
| 12 | Outcomes of cardiac resynchronization therapy in the elderly显示文摘 | Killu AM Wu JH Friedman PA | | 0，，： | 1 |
| 13 | Reasons for intracranial hypertension and hemodynamic instability during acute elevations of intra-abdominal pressure: observations in a large animal model显示文摘 | Rosenthal RJ Friedman RL Kahn AM | 1998 | J Gastrointest Surg1998，2，5： | 1 |
| 14 | Core mechanisms in ‘ theory of mind’显示文摘 | Leslie AM Friedman O German TP | 2004 | Trends Cogn Sci2004，8，12： | 1 |
| 15 | Age and experience- related improvements in gap detection in the rat显示文摘 | Friedman JT Peiffer AM Clark MG | 2004 | Brain Res Dev Brain Res2004，152，： | 1 |
| 16 | Prediction and prevention of ischemic placental disease显示文摘 | Friedman AM Cleary KL | 2014 | Semin Perinatol2014，38，3： | 1 |
| 17 | Dinueleotide repeats in the human surfaetant protein B gene and respiratory distress syndrome 显示文摘 | Floros J Veletza SV Kotikalapudi P Krizkova L Karinch AM Friedman C | 1995 | Biochem J1995，305，2： | 1 |
| 18 | Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis显示文摘 | Boutté AM Angela M Friedman David B Bogyo Matthew | 2011 | Faseb J2011，25，8： | 1 |
| 19 | Effect of amniotic fluid on cationic lipid mediated transfection and viral infection显示文摘 | Douar AM Themis M Friedman T | 1996 | Gene Therap1996，3，： | 1 |
| 20 | Prediction and prevention of ischemic placental disease显示文摘 | Friedman AM Cleary KL | | Semin Perinatol0，38，3： | 1 |
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