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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Colorectal cancer screening:20 years of development and recent progress显示文摘Colorectal cancer(CRC)is the second most common cancer in Europe and its incidence is steadily increasing.This trend could be reversed through timely secondary prevention(screening).In the last twenty years,CRC screening programs across Europe have experienced considerable improvements(fecal occult blood testing;transition from opportunistic to population based program settings).The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality rates.Each year,approximately 8000 people are diagnosed with CRC and some 4000 die from this malignancy.Twenty years ago,the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in 2000.Originally,this program was based on the guaiac fecal occult blood test(FOBT)offered by general practitioners,followed by colonoscopy in cases of FOBT positivity.The program has continuously evolved,namely with the implementation of immunochemical FOBTs and screening colonoscopy,as well as the involvement of gynecologists.Since the establishment of the Czech CRC Screening Registry in 2006,2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening program.The overall program expanded to cover 25.0%of the target population by 2011.However,stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation,which is currently being prepared. | Miroslav Zavoral Stepan Suchanek Ondrej Majek Premysl Fric Petra Minarikova Marek Minarik Bohumil Seifert Ladislav Dusek | 2014 | World Journal of Gastroenterology2014，20，14： | 16 |
| 3 | Colorectal cancer screening in Europe显示文摘Colorectal cancer(CRC)is the second most frequent malignant disease in Europe.Every year,412 000people are diagnosed with this condition,and 207 000patients die of it.In 2003,recommendations forscreening programs were issued by the Council of the European Union(EU),and these currently serve as thebasis for the preparation of European guidelines forCRC screening.The manner in which CRC screening iscarried out varies significantly from country to countrywithin the EU,both in terms of organization and thescreening test chosen.A screening program of onesort or another has been implemented in 19 of 27 EUcountries.The most frequently applied method is testing stool for occult bleeding(fecal occult blood test,FOBT).In recent years,a screening colonoscopy hasbeen introduced,either as the only method(Poland)orthe method of choice(Germany,Czech Republic). | Miroslav Zavoral Stepan Suchanek Filip Zavada Ladislav Dusek Jan Muzik Bohumil Seifert Premysl Fric | 2009 | World Journal of Gastroenterology2009，15，47： | 8 |
| 4 | Maintaining remission of ulcerative colitis with the prohiotic escherichia coil nissle 1917 is as effective as with standard mesalazine 显示文摘 | Kruis W Fric P Pokrotnieks J | 2004 | Gut2004，53，11： | 1 |
| 5 | Fractures of thescapular neck: diagnosis, classifications and treatment显示文摘 | Bartonlcek J Tucek M Fric V | 2014 | Int Orthop2014，38，10： | 1 |
| 6 | Scapular body fractures : results of operative treatment显示文摘 | Bartonicek J Fric V | 2011 | Int Orthop2011，35，5： | 1 |
| 7 | Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine显示文摘 | Kruis W Fric P Pokrotnieks J | 2004 | Gut2004，53，11： | 1 |
| 8 | NF A T control of innate immunity 显示文摘 | Fric J Zelante T Wong A Y | 2012 | Blood2012，120，7： | 1 |
| 9 | Double-blind comparison of an oral Escherichia coliprepration and mesalazine in maintaining remission of ulcerative colitis显示文摘 | Kruis W Schtz E Fric P | 1997 | Aliment Pharmacol Ther1997，11，： | 1 |
| 10 | Effects of fuel-air unmixedness on NOx emissions显示文摘 | Fric T F | 1993 | Journal of Propulsion Power1993，9，5： | 1 |
| 11 | Maintaining remission of ulcerative colitis with the probiotic Eschefichia call Nissle 1917 is as effective as with standard mesalazine显示文摘 | Kruis W Fric P Pokrotnieks J | 2004 | Gut2004，53，11： | 1 |
| 12 | Ultrasound estimation of volume of pleural fluid in mechanically ventilated patients显示文摘 | M Balik P Plasil P Waldauf J Pazout M Fric M Otahal J Pachl | 2006 | Intensive Care Medicine2006，，： | 1 |
| 13 | Effects of fuel-air unmixed ness on NOx emissions显示文摘 | FRIC F | 1993 | Journal of Propulsion and Power1993，9，5： | 1 |
| 14 | Vortical Structure in the Wake of a Transverse Jet 显示文摘 | Fric T F Roshko A | 1994 | Journal of Fluid Mechanics1994，279，： | 1 |
| 15 | An Evaluation of USBL and SBL Acoustic Systems and the Optimisation of Methods of Calibration-Part 1显示文摘 | D R C Philip DipHS FRICS Philip & Associates Ltd | 2003 | The Hydrographic Journal2003，108，： | 1 |
| 16 | Chikungunya virus neutraliza tion antigens and direct cell to-cell transmission are revealed by human antibody-escape mutants显示文摘 | Lee CY Kam YW Fric J | 2011 | PLoS Pathog2011，7，10： | 1 |
| 17 | An Evaluation of USBL and SBL Acoustic Systems and the Optimisation of Methods of Calibration-Part 3显示文摘 | D R C Philip DipHS FRICS Philip & Associates Ltd | 2003 | The Hydrographic Journal2003，110，： | 1 |
| 18 | An Evaluation of USBL and SBL Acoustic Systems and the Optimisation of Methods of Calibration-Part 2显示文摘 | D R C Philip DipHS FRICS Philip & Associates Ltd | 2003 | The Hydrographic Journal2003，109，： | 1 |
| 19 | Maintaining remission of ulcerative colitis with the probiotic Escherichia cali Nissle 1917 is as effective as with standard mesalazine 显示文摘 | Kruis W Fric P Pokrotnieks J | 2004 | Gut2004，53，11： | 1 |
| 20 | Avascular necrosis of the femoral head in pertrochanterie fractures : a report of 8 eases and a review of the literature 显示文摘 | Bartonfcek J Fric V Sk61a-Rosenbaum J | 2007 | J Orthop Trauma2007，21，4： | 1 |
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