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| 1 | Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transit显示文摘在附睾运输期间,精子获得新蛋白质。一些这些最新获得的蛋白质作为不可分的膜蛋白质表现,包括 glycosylphosphatidylinositol (GPI ) 抛锚的蛋白质。这建议分泌附睾蛋白质被不平常的机制转移到精子。在附睾腔以内,精子与小膜的泡交往命名 epididymosomes。许多蛋白质与 epididymosomes 被联系,这些泡的蛋白质作文沿着流出的管变化并且不同于 solubleintraluminal 蛋白质。一些联系 epididymosome 的蛋白质被识别了,他们在精子成熟的功能假设了。这些包括 P25b,带像素明星绑定蛋白质,巨噬细胞迁居抑制因子, polyol 小径的酶, HE5/CD52,类型 5 glutathioneperoxidase,和 SPAM1 或 PH-20。蛋白质的电泳模式联系了 toepididymosomes 是复杂的,一些这些蛋白质被转移到定义表面领域 ofepididymal 精子。从不同附睾片断收集的 Epididymosomes 与精子不同地交往。从 epididymosomes 的这蛋白质转移到精子 istime 依赖,温度依赖者并且 pH 依赖,并且面对锌是更有效的。一些蛋白质被分离到 epididymosomes 的类脂化合物木排领域并且有选择地被转移到精子血浆膜的木排领域。一些证据被介绍证明 thatepididymosomes 被附睾上皮细胞以一种泌离的方式分泌。在结论, epididymosomes 是在附睾的 intraluminalcompartment 以一种泌离的方式分泌的小膜的泡并且由成熟精子在新蛋白质的获得起一个主要作用。 | Robert Sullivan Gilles Frenette Julie Girouard | 2007 | Asian Journal of Andrology2007，9，4： | 26 |
| 2 | Targeted systemic therapies for hepatocellular carcinoma:Clinical perspectives,challenges and implications显示文摘Hepatocellular carcinoma(HCC) is a lethal disease in most patients,due to its aggressive course and a lack of effective systemic therapies for advanced disease.Surgical resection and liver transplantation remain the only curative options for a small subset of patients.Few patients with HCC are diagnosed early enough to be eligible for curative treatment.Angiogenesis inhibition is a natural therapeutic target for all solid tumors,but particularly for the highly vascularized HCC tumors.With the approval of the targeted agent sorafenib,there are now additional options for patients with HCC.Although sorafenib does produce some improvement in survival in HCC patients,the responses are not durable.In addition,there are significant dermatologic,gastrointestinal,and metabolic toxicities,and,as importantly,there is still limited knowledge of its usefulness in special subpopulations with HCC.Other angiogenesis inhibitors are in development to treat HCC both in the first-line setting and for use following sorafenib failure;the furthest in development is brivanib,a dual fibroblast growth factor pathway and vascular endothelial growth factor receptor inhibitor.Additional agents with antiangiogenic properties also in phase Ⅱ and Ⅲ development for the treatment of patients with HCC include bevacizumab,ramucirumab,ABT-869,everolimus and ARQ 197. | Catherine Frenette Robert Gish | 2012 | World Journal of Gastroenterology2012，18，6： | 10 |
| 3 | Comparison of esophageal capsule endoscopy and esophagogastroduodenoscopy for diagnosis of esophageal varices显示文摘AIM: To investigate the utility of esophageal capsule endoscopy in the diagnosis and grading of esophageal varices. METHODS: Cirrhotic patients who were undergo-ing esophagogastroduodenoscopy (EGD) for variceal screening or surveillance underwent capsule endos-copy. Two separate blinded investigators read each capsule endoscopy for the following results: variceal grade, need for treatment with variceal banding or prophylaxis with beta-blocker therapy, degree of portal hypertensive gastropathy, and gastric varices. RESULTS: Fifty patients underwent both capsule and EGD. Forty-eight patients had both procedures on the same day, and 2 patients had capsule endoscopy within 72 h of EGD. The accuracy of capsule endos- copy to decide on the need for prophylaxis was 74%, with sensitivity of 63% and specificity of 82%. Inter-rater agreement was moderate (kappa = 0.56). Agree-ment between EGD and capsule endoscopy on grade of varices was 0.53 (moderate). Inter-rater reliability was good (kappa = 0.77). In diagnosis of portal hyper-tensive gastropathy, accuracy was 57%, with sensitiv-ity of 96% and specificity of 17%. Two patients had gastric varices seen on EGD, one of which was seen on capsule endoscopy. There were no complications from capsule endoscopy.CONCLUSION: We conclude that capsule endoscopy has a limited role in deciding which patients would benefit from EGD with banding or beta-blocker thera-py. More data is needed to assess accuracy for staging esophageal varices, PHG, and the detection of gastric varices. | Catherine T Frenette John G Kuldau Donald J Hillebrand Jill Lane Paul J Pockros | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 4 | Pulmonary complications of transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘Transcatheter arterial chemoembolization(TACE) is an effective palliative intervention that is widely accepted for the management of hepatocellular carcinoma(HCC). Post-TACE pulmonary complications resulting in acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) are rare events. Pulmonary complications after TACE are thought to be related to chemical injury subsequent to the migration of the infused ethiodized oil or chemotherapeutic agent to the lung vasculature, facilitated by arteriovenous(AV) shunts within the hyper-vascular HCC. We review herein the literature on pulmonary complications related to TACE for HCC. Post-TACE pulmonary complications have included pulmonary oil embolism, interstitial pneumonitis, chemical pneumonitis, ALI, ARDS, lipoid pneumonia, acute eosinophilic and neutrophilic pneumonia, bilious pleuritis, pulmonary abscess, pulmonary tumor embolism, and possibly pulmonary metastasis with HCC. The risk factors associated with post-TACE pulmonary complications identified in the literature include large hyper-vascular HCC with AV shunts, large-volume Lipiodol infusion, and embolization via the right inferior phrenic artery. However, the absence of known risk factors is not a guarantee against serious complications. An astute awareness of the potential post-TACE pulmonary complications should expedite appropriate therapeutic interventions and increase potential for early recovery. | Quan M Nhu Harry Knowles Paul J Pockros Catherine T Frenette | 2016 | World Journal of Respirology2016，6，3： | 4 |
| 5 | Hepatocellular Carcinoma:Downstaging to Liver Transplantation as Curative Therapy显示文摘Hepatocellular carcinoma(HCC)ranks among the leading cancer-related causes of morbidity and mortality worldwide.Downstaging of HCC has prevailed as a key method to curative therapy for patients who present with unresectable HCC outside of the listing criteria for liver transplantation(LT).Even though LT paves the way to lifesaving curative therapy for HCC,perpetually severe organ shortage limits its broader application.Debate over the optimal protocol and assessment of response to downstaging treatment has fueled immense research activity and is pushing the boundaries of LT candidate selection criteria.The implicit obligation of refining downstaging protocol is to ensure the maximization of the transplant survival benefit by taking into account the waitlist life expectancy.In the following review,we critically discuss strategies to best optimize downstaging HCC to LT on the basis of existing literature. | Leana Frankul Catherine Frenette | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 2 |
| 6 | Insulin decreases the serum potassium concentration during the anhepatic stage of liver transplantation 显示文摘 | De Wlof A Frenette Kang Y | 1993 | Anesthesiology1993，78，4： | 1 |
| 7 | Thiopental- induced neutropenia in two patients with severe head trauma显示文摘 | Frenette A Perreault MM Lan S | 2007 | Pharmacotherapy2007，27，3： | 1 |
| 8 | Preterm prelabour rup- ture of membranes: effect of latency on neonatal and maternal outcomes 显示文摘 | Frenette P Dodds L Armson BA | 2013 | J Obstet Gynaecol Can2013，35，8： | 1 |
| 9 | Measurement of the Alkali Content of Concrete Using Hot-Water Extraction显示文摘 | Berube M A Frenette J Rivest M | 2002 | Cement Concrete and Aggregate2002，24，1： | 1 |
| 10 | Sleep disturbances in prepubertal children with attention deficit hyperactivity disorder: a home polysomnography study显示文摘 | Gruber R Xi T Frenette S | 2009 | Sleep2009，32，3： | 1 |
| 11 | Prostatic Kallikrein hk2, but not prostate-specific antigen (hk3), activates singlechain urokinase-type plasminogen activator 显示文摘 | Frenette G Tremblay R R Lazure C | 1997 | Int J Cancer1997，71，5： | 1 |
| 12 | Hematopoietic stem cell trafficking: regulated adhesion and attraction to bone marrow microenvironment 显示文摘 | Mendez-Ferrer S Frenette P S | 2007 | Ann N Y Acad Sci2007，1116，： | 1 |
| 13 | Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow显示文摘 | Frenette PS Subbarao S Mazo IB | 1998 | Proc Natl Acad Sci USA1998，95，14： | 1 |
| 14 | Hepatocellular carcinoma: molecular and genomie guideline for the clinician显示文摘 | Frenette C Gish RG | 2011 | Clin Liver Dis2011，15，2： | 1 |
| 15 | Economic & commercial viability of hydrogen fuel cell vehicles from an auto-motive manufacturer perspective显示文摘 | Frenette G Forthoffer D | | 0，，09： | 1 |
| 16 | The meaning, the sense and the significance: translating the science of mesen- chymal stem cells into medicine显示文摘 | Bianco P Cao X Frenette P S | 2013 | Nature Medi2013，19，1： | 1 |
| 17 | The meaning, the senseand the significance: translating the science of mesenchymal stemcells into medicine 显示文摘 | Bianco P Cao X Frenette PS | 2013 | Nat Med2013，19，1： | 1 |
| 18 | Coaggregation of Streptococcus salivarius with periodontopathogens: evidence for involvement of fimbriae in the interaction with Prevotella intermedia显示文摘 | Lévesque C Lamothe J Frenette M | 2003 | Oral Microbiol Immunol2003，18，5： | 1 |
| 19 | Preterm prelabour rupture of membranes :Effect of latency on neonatal and maternal outcomes显示文摘 | Frenette P Dodds L Armson BA | 2013 | Obstet Gynaecol Can2013，35，8： | 1 |
| 20 | Insulin decreases the serum potassium concentration during the anhe- patic stage of liver transplantation显示文摘 | De Wlof A Frenette L Kang Y | 1993 | Anesthesiology1993，78，： | 1 |
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