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| 1 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 2 | Isolation and characterisation of human gingival margin-derived STRO-1/MACS^+ and MACS^-cell populations显示文摘Recently,gingival margin-derived stem/progenitor cells isolated via STRO-1/magnetic activated cell sorting(MACS) showed remarkable periodontal regenerative potential in vivo.As a second-stage investigation,the present study's aim was to perform in vitro characterisation and comparison of the stem/progenitor cell characteristics of sorted STRO-1-positive(MACS^+) and STRO-1-negative(MACS^-) cell populations from the human free gingival margin.Cells were isolated from the free gingiva using a minimally invasive technique and were magnetically sorted using anti-STRO-1 antibodies.Subsequently,the MACS^+ and MACS^- cell fractions were characterized by flow cytometry for expression of CD14,CD34,CD45,CD73,CD90,CD105,CD146/MUC18 and STRO-1.Colony-forming unit(CFU) and multilineage differentiation potential were assayed for both cell fractions.Mineralisation marker expression was examined using real-time polymerase chain reaction(PCR).MACS^+ and MACS- cell fractions showed plastic adherence.MACS^+ cells,in contrast to MACS- cells,showed all of the predefined mesenchymal stem/progenitor cell characteristics and a significantly higher number of CFUs(P<0.01).More than 95%of MACS^+ cells expressed CD105,CD90 and CD73;lacked the haematopoietic markers CD45,CD34 and CD14,and expressed STRO-1 and CD146/MUC18.MACS- cells showed a different surface marker expression profile,with almost no expression of CD14 or STRO-1,and more than 95%of these cells expressed CD73,CD90 and CD146/MUC18,as well as the haematopoietic markers CD34 and CD45 and CD105.MACS^+ cells could be differentiated along osteoblastic,adipocytic and chondroblastic lineages.In contrast,MACS- cells demonstrated slight osteogenic potential.Unstimulated MACS^+ cells showed significantly higher expression of collagen I(P<0.05) and collagen III(P<0.01),whereas MACS^- cells demonstrated higher expression of osteonectin(P<0.05;MannWhitney).The present study is the first to compare gingival MACS^+ and MACS- cell populations demonstrating that MACS^+ cells,in contrast to MACS- cells,harbour stem/progenitor cell characteristics.This study also validates the effectiveness of the STRO-l/MACS^+technique for the isolation of gingival stem/progenitor cells.Human free gingival margin-derived STRO-1/MACS^+ cells are a unique renewable source of multipotent stem/progenitor cells. | Karim M Fawzy El-Sayed Sebastian Paris Christian Graetz Neemat Kassem Mohamed Mekhemar Hendrick Ungefroren Fred Fndrich Christof Drfer | 2015 | International Journal of Oral Science2015，7，2： | 6 |
| 3 | Time scale for wave/current scour below pipeline 显示文摘 | FREDSφE J SUMER B M ARNSKOV M | 1992 | International Journal of Offshore and Polar Engineering1992，2，2： | 1 |
| 4 | Hot-cor- rosion Resistance of Ni-Cr-A1-Y and Ni-18 % Si SI- loys in Sulfate Eutectic and Sulfate Plus Vanadate Melts at 973 K 显示文摘 | BRUCE M W FRED S P GERALD H M | 2002 | Oxidation of Metals2002，58，56： | 1 |
| 5 | Edward modeling of two-dimensional spiral inductors显示文摘 | M Dishman John T Dickens Fred W Whelan | 1980 | IEEE Transactions on Components Hybrids and Manufacturing Technology1980，3，4： | 1 |
| 6 | Investigation of boiling front during vacuum drying of wood 显示文摘 | Chen Zhangjing Fred M Lamb | 2001 | Wood and Fiber Science2001，35，4： | 1 |
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| 8 | Balanced scorecard, activity-based costing and company performance: An empirical analysis 显示文摘 | ADAM S M FRED A J | 2003 | Journal of Managerial Issues2003，15，3： | 1 |
| 9 | Synthesis of ring-fused pyrroles显示文摘 | Fred M Hershenson | 1975 | J Org Chem1975，40，6： | 1 |
| 10 | Flow injection analysis using pH/pF ISFET combinations for determination of very low fluoride concentrations 显示文摘 | Werner M Fred L Van Der Sehoot B H | 1993 | Sensors and Actuators B1993，1516，： | 1 |
| 11 | High speed label-free detection by spinning disk micro-interferometry 显示文摘 | Manoj M Varma Halina D Inerowicz Fred E Regnier | 2004 | Biosensors and Bioelectronics2004，19，11： | 1 |
| 12 | Protection against infection and abortion induced by virulent Challenge exposure after oral vaccination of Cattle with Brucella abortus strain RB51显示文摘 | Philip H E Fred M E Colby L | 1998 | AJNR1998，59，12： | 1 |
| 13 | Antioxidant content of whole grain breakfast cereals, fruits and vegetables显示文摘 | Harold E M Fred R Leonard M | 2000 | Journal of the American College of Nutrition2000，19，3： | 1 |
| 14 | Meta-Analysis of the Impact of Positive Psychological Capital on Employee Atti- tudes, Behaviors, and Performance显示文摘 | James B A Rebecca J R Fred L Ketan H M | 2011 | Human Resource Develop- ment Quarterly2011，，2： | 1 |
| 15 | Immunolodulation of autoimmune and inflammatory disease with intravenous slobulin显示文摘 | IAN R M FRED S R | 2001 | N Engl J Med2001，345，10： | 1 |
| 16 | Isolation, identification, and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile 显示文摘 | Vanda Richard N B Fred A M | 2004 | Phytochemisty2004，65，： | 1 |
| 17 | Word-of-Mouth Com-munication in the Service Marketplace显示文摘 | MANGOLD W G FRED M | 1999 | Journal ofServices Marketing1999，13，1： | 1 |
| 18 | Robust monolithic ultraviolet interferometer for the SHIMMER instrument on STPSat-I 显示文摘 | John M Harlander Fred L Roesler Christoph R Engiert | 2003 | Optical Society of America2003，42，15： | 1 |
| 19 | Safer sex communication and unsafe sexual behavior among young men who have sex with men in Calirofnial显示文摘 | Fred M Matthew F Juan DR | 1999 | Archives of Sexual Behavior1999，28，4： | 1 |
| 20 | The predictive value of D-dimer measurement for cancer in patients with deep vein thrombosis显示文摘 | ROGER E G S MARIELLE M J B FRED J L M | 2005 | Haematologica2005，90，： | 1 |
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