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| 1 | Factors associated with health-related quality of life for adults with stroke sequelae显示文摘 | Fróes KS Valdés MT Lopes Dde P | | 0，，2： | 1 |
| 2 | Prevalence,phenotype and medication for the pediatric inflammatory bowel disease population of a state in Southeastern Brazil显示文摘BACKGROUND Inflammatory bowel disease(IBD)can lead to social and economic impacts worldwide.In Brazil,where its adult prevalence is increasing,the epidemiology of the pediatric population is not well known,although there is a documented increase in pediatric IBD incidence worldwide.Brazil has continental dimensions,and Espírito Santo is a state of southeastern Brazil,the region with the highest demographic densities and is the economically most important in the country.AIM To assess the prevalence,incidence,phenotype and medications in a Southeastern Brazilian pediatric population.METHODS Data were retrieved from the Public Medication-Dispensing System of the Department of Health in Espírito Santo state from documentation required to have access to highly expensive medication from August 1,2012 to July 31,2014.There were 1048 registered patients with IBD of all ages,and of these patients,the cases≤17 years were selected.The data were obtained through the analysis of administrative requests for these medications and included medical reports,endoscopy exams,histopathology and imaging tests,which followed the Clinical Protocols and Therapeutic Guidelines of the Brazilian Government.Only confirmed cases of IBD were included in the study.RESULTS There were 55 pediatric patients/1048 registered patients(5.34%),with Crohn's disease(CD)representing 30/55(55%),ulcerative colitis(UC)24/55(43.6%)and 1 unclassified IBD,a significant difference from adult patients(P=0.004).The prevalence of IBD in pediatric patients was 5.02 cases/100.000 inhabitants;the incidence in 2014 was 1.36 cases/100.000 inhabitants.The mean age at diagnosis was 12.2 years(±4.2).There were 7 children diagnosed up to 6 years old,7 between 7 to 10 years old and 41 between 11 and≤17 years old.There was no difference in the distribution of UC and CD between these age categories(P=0.743).There was no difference in gender distribution in relation to adults.Children and adolescents with UC had a predominance of pancolitis,unlike adults(P=0.001),and used aminosalicylates and immunomodulators for their treatment.Pediatric patients with CD did not present a difference in disease location but had a higher frequency of fistulizing behavior(P=0.03)and perianal disease phenotype(P=0.007)than adult patients.Patients with CD used more immunomodulators and biological therapy.Treatment with biological therapy was more frequently used in pediatric patients than in adults(P<0.001).CONCLUSION Although the data from this study demonstrate that incidence and prevalence rates are low in southeastern Brazil,these data demonstrate the severity of IBD in pediatric patients,with the need for early diagnosis and therapy,avoiding serious damage. | Adalberta Lima Martins Renata de SáBrito Fróes Maria da Penha Zago-Gomes | 2022 | World Journal of Clinical Pediatrics2022，11，4： | 0 |
| 3 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
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