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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Clinical trial design fortarget-based therapy 显示文摘 | Fox E Curt GA Bails FM | 2002 | Oncologist2002，7，5： | 1 |
| 3 | Heart rate:a risk factor for cardiac diseases and outcomes Pathophysiology of cardiac diseases and the potential role of heart slowing显示文摘 | Lanza GA Fox K Crea F | 2006 | Adv Cardiol2006，43，： | 1 |
| 4 | Surgical exposure of the fundus of the internal auditory canal:anatomic limits of the middle fossa versus the retrosigmoid transcanal approach显示文摘 | Haberkamp TJ Meyer GA Fox M | 1998 | Laryngoscope1998，108，81： | 1 |
| 5 | Heart rate : A risk factor for cardiac diseases and outcomes? Pathophysiology of cardiac diseases and the potential role of heart rate slowing显示文摘 | LANZA GA FOX K CREA F | 2006 | Adv Cardiol2006，43，： | 1 |
| 6 | Studies on the treatment of tuberculosis undertaken by the British Medical Research Council Tuberculosis Units 1946-1986,with relevant subsequent publications显示文摘 | Fox W Ellard GA Mitchison DA | 1999 | Int J Tuberc Lung Dis1999，，3： | 1 |
| 7 | Studies on the treatment of tuberculosis undertaken by the British Medical Research Council Tuberculosis Units 1946-1986, with relevant subsequent publications显示文摘 | Fox W Ellard GA Mitchison DA | 1999 | Int J Tuberc Lung Dis1999，3，： | 1 |
| 8 | Induced minisatellite germline mutations in herring gulls (Larus argentatus) living near steel mills显示文摘 | Yauk CL Fox GA McCarry BE | 2000 | Mutat Res2000，452，： | 1 |
| 9 | Monitoring the elimination of persistent toxic substances from the Great Lakes; Chemical and physiological evidence from adult herring gulls 显示文摘 | Fox GA Trudeau S Won H | 1998 | Environ Monitoring and Assessment1998，53，1： | 1 |
| 10 | Production of surfactant from Bacillus subtilis ATCC 21332 using potato substrates显示文摘 | Fox SL Bala GA | 2000 | Bioresour Technol2000，75，3： | 1 |
| 11 | Heart rate : a risk factor for cardiac diseases and outcomes? Pathophysiology of cardiac diseases and the potential role of heart slowing显示文摘 | Lanza GA Fox K Crea F | 2006 | Adv Cardiol2006，43，： | 1 |
| 12 | Localising maxillary canines using dental panoramic tomography显示文摘 | Fox NA Fletcher GA Homer K | 1995 | Br Dent J1995，179，1112： | 1 |
| 13 | Experimental investigation of direct connectivity between macropores and subsurface drains during infiltration显示文摘 | Akay O Fox GA | 2007 | Soil Science Society of American Journal2007，71，： | 1 |
| 14 | Studies on the treatment of tuberculosis undertaken by the British Medical Research Council Tuberculosis Units,1946-1986,with relevant subsequent publications显示文摘 | Fox W Ellard GA Mitchison DA | 1999 | Int J Tuberc Lung Dis1999，3，： | 1 |
| 15 | High numbers of tumor-infil-trating Foxp3-regulatory T cells are associated with improved o-verall survival in follicular lymphoma显示文摘 | Carreras J Lopez GA Fox BC | 2006 | Blood2006，108，61： | 1 |
| 16 | Heart rate:a risk factor for cardiac diseases and outcomes?Pathophysiology of cardiac diseases and the potential role of heart slowing显示文摘 | Lanza GA Fox K Crea F | 2006 | Adv Cardiol2006，43，： | 1 |
| 17 | Comparison of eight diagnostic blood tests for heartworm infection in dogs 显示文摘 | HOOVER J P CAMPBELL GA FOX J C | 1996 | Canine Pract1996，21，1： | 1 |
| 18 | Localising maxillary canines using dental panoramic tomography 显示文摘 | Fox NA Fletcher GA Homer K | 1995 | Br Dent J1995，179，1112： | 1 |
| 19 | Surgical exposure of the fundus of the internal auditory canal:anatomical limits of the middle fossa versus the retrosigmoid transcanal approach显示文摘 | Haberkamp TJ Meyer GA Fox M | 1998 | Laryngoscope1998，108，： | 1 |
| 20 | Estimation of soil organic matter from red and nearinfrared remotely sensed data using a soil line Euclidean distance technique显示文摘 | FOX GA SABBAGH GJ | 2002 | Soil Science Society of America Journal2002，，66： | 1 |
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