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| 1 | MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration显示文摘 | Arora S Ranade AR Tran NL Nasser S Sridhar S Korn RL Ross JT Dhruv H Foss KM Sibenaller Z Ryken T Gotway MB Kim S Weiss GJ | 2011 | 中国神经肿瘤杂志2011，9，1： | 30 |
| 2 | Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis显示文摘AIM: To evaluate the effect of orally administeredplecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.METHODS: The cyclic guanosine monophosphate(cG MP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma T84 cellbased assay. For animal studies all test agents were formulated in phosphate buffered saline. Sulfasalazine or 5-amino salicylic acid(5-ASA) served as positive controls. Effect of oral treatment with test agents on amelioration of acute colitis induced either by dextran sulfate sodium(DSS) in drinking water or by rectal instillation of trinitrobenzene sulfonic(TNBS) acid, was examined in BALB/c and/or BDF1 mice. Additionally, the effect of orally administered plecanatide on the spontaneous colitis in T-cell receptor alpha knockout(TCRα-/-) mice was also examined. Amelioration of colitis was assessed by monitoring severity of colitis, disease activity index and by histopathology. Frozen colon tissues were used to measure myeloperoxidase activity.RESULTS: Plecanatide and dolcanatide are structurally related analogs of uroguanylin, which is an endogenous ligand of guanylate cyclase-C(GC-C). As expected from the agonists of GC-C, both plecanatide and dolcanatide exhibited potent cG MP-stimulatory activity in T84 cells. Once-daily treatment by oral gavage with either of these analogs(0.05-0.5 mg/kg) ameliorated colitis in both DSS and TNBS-induced models of acute colitis, as assessed by body weight, reduction in colitis severity(P < 0.05) and disease activity index(P < 0.05). Amelioration of colitis by either of the drug candidates was comparable to that achieved by orally administered sulfasalazine or 5-ASA. Plecanatide also effectively ameliorated colitis in TCRα-/- mice, a model of spontaneous colitis. As dolcanatide exhibited higher resistance to proteolysis in simulated gastric and intestinal juices, it was selected for further studies. CONCLUSION: This is the first-ever study reporting the therapeutic utility of GC-C agonists as a new class of orally delivered and mucosally active drug candidates for the treatment of inflammatory bowel diseases. | Kunwar Shailubhai Vaseem Palejwala Krishna Priya Arjunan Sayali Saykhedkar Bradley Nefsky John A Foss Stephen Comiskey Gary S Jacob Scott E Plevy | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 5 |
| 3 | Origin of pit chains in the floor of lunar Copernican craters显示文摘There are small pit chains in the floor of lunar Copernican craters. They are usually so small in scale that there are few lunar spacecrafts to detect their detailed morphology. Combining camera data from Lunar Orbiter, Lunar Reconnaissance Orbiter (LRO), Kaguya and Chang’e-1 missions, 5 representative large Copernican craters on various terrains of the lunar surface are chosen to study the origin of the pit chains in the crater floor. The morphology and distribution characteristic of the pit chains are referred by the high resolution images in this research. It is suggested that it is the magma activities from the subsurface magma layer combining with the existence of fractures and faults under the crater floor that leaded the formation of the pit chains. The model is further verified and discussed using the regolith thickness data in the crater floor. Our model suggests that the pit chains are still developing in the floor of the Copernican craters and the Moon may not be totally cold. Finally, the model limitation and potential future work are discussed based on available data. | XIAO ZhiYong 1* , ZENG ZuoXun 1,2 , XIAO Long 1,2 , FA WenZhe 3 & HUANG Qian 3,4 1 Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 2 Research Center for Space Science and Technology, China University of Geosciences, Wuhan 430074, China 3 Institut de Physique du Globe de Paris, 4 Avenue de Neptune, Saint Maur des Fosse’s, 94100, France 4 Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 4 |
| 4 | Dynamic thermal line rating,part Ⅱ-conductor temperature sensor and laboratory field test evaluation显示文摘 | Hall S Foss S Lin S H | | 0，，： | 1 |
| 5 | Natural occurrence of enantiomeric and meso astaxanthin in crustaceans including zooplankton显示文摘 | FOSS P LIAAEN-JENSEN S | | 0，，： | 1 |
| 6 | Dynamic line rating in the operating environment显示文摘 | Foss S D Maraio R A | | 0，，： | 1 |
| 7 | On a Voronoi aggregative process related to a bivariate Poisson process 显示文摘 | Foss S G Zuyev S A | 1996 | Advances in Applied Probability1996，28，4： | 1 |
| 8 | Compensatory growth and fillet crude composition in juvenile Atlantic halibut : Effects of short term starvation periods and subsequent feeding显示文摘 | HEIDE A FOSS A STEFANSSON S O | 2006 | Aquaculture2006，261，1： | 1 |
| 9 | Ellipsometric study of the influence of chemical etching on thin porous sili- con structures显示文摘 | Selj J ThqSgersen A Foss S E | 2011 | Thin Solid Films2011，519，9： | 1 |
| 10 | The interaction of temperature and salinity on growth and food conversion in juvenile turbot (Scophthalmus maximus)显示文摘 | IMSLAND A K FOSS A GUNNARSSON S | 2001 | Aquaculture2001，198，3： | 1 |
| 11 | Origin of primary gastric T-cell lymphomas from intraepithelial T-lymphocytes: report of two cases显示文摘 | Foss HD Schmitt-Graff A Daum S | 1999 | Histopathology1999，34，1： | 1 |
| 12 | Governing knowledge sharing in organizations: Levels of analysis, governance mechanisms, and research directions 显示文摘 | Foss N F Husted K Michailova S | 2010 | Journal of Management Studies2010，47，3： | 1 |
| 13 | Governing knowledge sharing in organizations:Levels of analysis,governance mechanisms and research directionsjoms显示文摘 | Foss N J Husted K Michailova S | 2010 | Journal of Management Studies2010，47，3： | 1 |
| 14 | Techniques for characterizing bituminous materials using a versatile triaxial testing system 显示文摘 | Terrel R L Awad I S Foss L R | 1974 | ASTM Special Technical Publication1974，，561： | 1 |
| 15 | The interaction of tem-perature and salinity on growth and food conversion in juvenile tur-bot(Scophthalmus maximus)显示文摘 | Imsland A K Foss A Gunnarsson S | 2001 | Aquaculture2001，198，： | 1 |
| 16 | The interaction of temperature and salinity on growth and food conversion in juvenile turbot ( Scophthalmus maximus ) 显示文摘 | IMSLAND A K FOSS A GUNNARSSON S et at | 2001 | Aquaculture2001，198，： | 1 |
| 17 | Liver transplantation for cholangiocarcinoma: selection is essential for acceptable results 显示文摘 | Friman S Foss A Isoniemi H | 2011 | Scand J Gastroentero12011，46，3： | 1 |
| 18 | The MILS architecture for high-assurance embedded systems显示文摘 | FOSS J A HARRISON W S OMAN P | | 0，，03： | 1 |
| 19 | Safety and tolerance of methylnaltrexone in healthy humans: a randomized, placebo controlled,intravenous,ascending dose, pharmacokinetic study显示文摘 | M F O'CONNOR C S YUAN | 1997 | J Clin Pharmacol1997，37，： | 1 |
| 20 | Asymptotics for sums of random variables with local subexponential behavior显示文摘 | Asmussen S Foss S Korshunov D | 2003 | Theor Probab2003，16，： | 1 |
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