|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 精子DNA损伤的机制和临床应用显示文摘在男性配子各种不同的DNA异常中,DNA断裂最为常见,尤其是在不育症患者中。目前越来越多的研究表明,DNA断裂并不显著影响精子细胞的存活率、活动率、形态以及与卵细胞的结合能力。研究还证明,卵母细胞在一定程度上可以修复受损的DNA,其修复程度依赖于精子细胞DNA的损伤类型和卵母细胞的质量。因此,研究精子DNA断裂(SDF)在自然分娩或辅助生殖技术助孕中对胚胎发育、胚胎着床、妊娠结果、子代健康的影响变得非常重要。至今,针对SDF对生殖的影响的研究极少,且研究报道的结论很不一致。导致这种不一致的原因可能与检测SDF的手段不同、实验设计不同和精液标本选择标准不同有关。因此,目前还不能确定是否将SDF检测拽术砬用于受精评估和ART技术中。这表明,制定SDF检测技术的标准化方法势在必行,另外关于SDF对ART的影响有必要进行进一步的临床研究。 | Lara Tamburrino Sara Marchiani Margarita Montoya Francesco Elia Marino Ilaria Natali Marta Cambi Gianni Forti Elisabetta Baldi Monica Muratori | 2012 | Asian Journal of Andrology2012,14,1: | 16 |
| 2 | 【原创论文】不育夫妇中男方的代谢综合征与前列腺异常的情况显示文摘目前尚无年轻男性不育症患者代谢综合征与前列腺相关的症状和体征之间关系的系统研究。我们研究了171对不育夫妇中的男性(36.5±8.3岁),代谢综合征是根据国家胆固醇教育计划成人治疗专题小组第三次报告确定。所有人接受了激素(包括总睾酮和胰岛素)、精液f包括白细胞介素8,精浆中白细胞介素8(SIL-8))、阴囊及经直肠超声评估。因为我们此前已有大样本队列研究了不育男性代谢综合征和阴囊检测指标之间的相关性,这里我们重点研究代谢综合征与经直肠前列腺B超资料的相关性。前列腺相关症状采用美国国立卫生研究院评估慢性前列腺炎症状指数(NIH-CPSI)和国际前列腺症状评分(iPSS)。22位受试者符合代谢综合征的诊断标准。经年龄调整后的有序多项Logistic回归模型分析显示:胰岛素水平增加是代谢综合征的一个组分(Wald=29.5,P〈0.0001)并与TT负相关(调整后的r=0.359,P〈O.0001)。未观察到代谢综合征和NIH.CPSI或IPSS评分之间有相关性。经年龄、睾酮、胰岛素校正后有序多项Logistic回归模型显示:代谢综合征组分数目的增加与正常精子形态负相关(Wald=5.59,P〈0.02)、与前列腺炎症的分子标志物血清sIL-8水平正相关(Wald=4.32,P〈0.05),与前列腺总体积和移行带体积(Wald=17.6和12.5,P〈0.0001)、动脉收缩期峰值流速(Wald=9.57,P=0.002)、质地不均匀性(HR=8711.05—3.33],P〈0.05)、钙化灶大小(Wald=3.11,P〈0.05)正相关,但不与精囊体积或功能指标正相关。总之,不育夫妇中的男性代谢综合征与前列腺增大、生化指标(sIL8)和前列腺炎症的超声指标呈正相关,而与前列腺相关症状无正相关,表明代谢综合征可能是良性前列腺增生症的早期亚临床表现的触发点。 | Francesco Lotti Giovanni Corona Linda Vignozzi Matteo Rossi Elisa Maseroli Sarah Cipriani Mauro Gacci Gianni Forti Mario Maggi | 2014 | Asian Journal of Andrology2014,16,2: | 6 |
| 3 | Superlubricity of epitaxial monolayer WS2 on graphene显示文摘We report the superlubric sliding of monolayer tungsten disulfide (WS2) onepitaxial graphene (EG) grown on silicon carbide (SIC). Single-crystalline WS2flakes with lateral size of hundreds of nanometers are obtained via chemicalvapor deposition (CVD) on EG. Microscopic and diffraction analyses indicatethat the WS2/EG stack is predominantly aligned with zero azimuthal rotation.The present experiments show that, when perturbed by a scanning probemicroscopy (SPM) tip, the WS2 flakes are prone to slide over the graphenesurfaces at room temperature. Atomistic force field-based molecular dynamicssimulations indicate that, through local physical deformation of the WS2 flake,the scanning tip releases enough energy to the flake to overcome the motionactivation barrier and trigger an ultralow-friction rototranslational displacement,that is superlubric. Experimental observations show that, after sliding, the WS2flakes come to rest with a rotation of nn/3 with respect to graphene. Moreover,atomically resolved measurements show that the interface is atomically sharpand the WS2 lattice is strain-free. These results help to shed light on nano-tribological phenomena in van der Waals (vdW) heterostacks, and suggest thatthe applicative potential of the WS2/graphene heterostructure can be extendedby novel mechanical prospects. | Holger Buch Antonio Rossi Stiven Forti Domenica Convertino Valentina Tozzini Camilla Coletti | 2018 | Nano Research2018,11,11: | 3 |
| 4 | DNA fragmentation in two cytometric sperm populations: relationship with clinical and ultrasound characteristics of the male genital tract显示文摘我们调查了是否在二张 cytometric 精子人口的 DNA 破碎(PI 更暗淡的 和 PI 有不同生物特征和临床的关联的更明亮的 ) 与有关临床并且男生殖道的 color-Doppler 超声(CDUS ) 参数。没有基因畸形的不肥沃的夫妇的 160 男性被评估为临床,阴囊,并且 transrectal CDUS 特征,像前列腺炎的症状的存在(与公民一起,健康长期的前列腺炎症状的研究所索引)并且在 PI 更暗淡的和 PI 更明亮的人口(用 TUNEL/PI ,方法结合了流动 cytometry )。数据好久被调整(模型 1 ) 与腰围,睾丸激素层次,吸烟习惯,和性节制(模型 2 ) 一起。根据统计模型 2, PI 更暗淡的 sDF 与阴囊的畸形被联系,包括降低临床并且超声体积(r = 0.21 并且 r = 0.20 分别地;P < 0.05 ) ,更高的 FSH 层次(r = 0.34, P < 0.0001 ) 并且阴囊的不同类的出现(P < 0.05 ) 并且 hypoechogenicity (P < 0.05 ) 。 PI 更明亮的 sDF 与前列腺相关的症状和反常符号被联系包括全部的更高的 NIH-CPSI 和子域分数,像前列腺炎的症状并且象宏石灰化那样的 CDUS 改变的更高的流行,严重回响质地不同类, hyperemia (所有 P < 0.05 ),并且更高动脉的山峰收缩速度( r = 0.25 , P < 0.05 )。我们的结果在 PI 更暗淡的 精子,与差的精液质量有关,主要在睾丸发源,由于 apoptosis 可能。相反地,在 PI 更明亮的 精子看起来主要通过前列腺发源在期间或在运输以后,与机关的煽动性的地位的存在增加。这些结果能导致新观点让治疗学的目标的鉴定减少 sDF。 | Francesco Lotti Lara Tamburrino Sara Marchiani Elisa Maseroli Pasquale Vitale Gianni Forti Monica Muratori Mario Maggi Elisabetta Baldi | 2017 | Asian Journal of Andrology2017,19,3: | 2 |
| 5 | Experimental investigation of the tension band in fractures of the patella显示文摘 | A.P Fortis Z Milis V Kostopoulos S Tsantzalis P Kormas N Tzinieris Th Boudouris | 2002 | Injury2002,,6: | 2 |
| 6 | Clinical efficacy of dexmedetomidine alone is less than propofol for conscious sedation during ERCP显示文摘 | MULLER S BOROWICS SM FORTIS EA | 2008 | Gastrointest Endosc2008,67,4: | 1 |
| 7 | New conditions for global stability of neural networks with application to linear and quadratic programming problems显示文摘 | Forti M Tesi A | 1995 | IEEE Transactions on Circuits Systems - I1995,42,7: | 1 |
| 8 | Clinical efficacy of dexmedetomidine alone is less than propofol for conscious sedation during ERCP显示文摘 | MULLER S BOROWICS SM FORTIS EA | 2008 | Gastrointest Endosc2008,67,4: | 1 |
| 9 | HER2 as a prognostic factor in breast cancer显示文摘 | Menard S Fortis S Castiglioni F | 2001 | Oncology2001,61,: | 1 |
| 10 | HER2 as a prognostic factor in breast cancer显示文摘 | Menard S Fortis S Castiglioni F | 2001 | Oncology2001,61,2: | 1 |
| 11 | Clinical efficacy ofdexmedetomidine alone is less than propofol for conscioussedation during ERCP显示文摘 | Muller S Borrowies SM Fortis EA | 2008 | Gastrointest Endosc2008,67,4: | 1 |
| 12 | Global exponential stability and global convergence in finite time of delayed neural networks with infinite gain显示文摘 | Forti M Nistri P Papini D | | 0,,06: | 1 |
| 13 | Mycobacterium tuberculosis FurA autoregulates its own expression 显示文摘 | Sala C Forti F Di Florio E | 2003 | J Bacteriol2003,185,18: | 1 |
| 14 | New insighls into the role of extracellular matrix during tumor onset and progression 显示文摘 | Pupa SM Menard S Forti S | 2002 | J Cell Physiol2002,192,3: | 1 |
| 15 | Schizophrenia as a GSK-3 dysregulation disorder 显示文摘 | Lovestone S Killick R Di Forti M | 2007 | Trends Neurosci2007,30,4: | 1 |
| 16 | Necessary and sufficient condition for absolute stability of neural networks 显示文摘 | Forti M Ma~etti S Marini M | 1994 | IEEE Trans Circuits Syst I1994,41,7: | 1 |
| 17 | Transcriptional regulation of furA and katG upon oxidative stress in Mycobacterium smegmatis 显示文摘 | Milano A Forti F Sala C | 2001 | J Bacteriol2001,183,23: | 1 |
| 18 | Effect of micronutrient status on natural killer cell immune function in healthy freeliving subjects aged 2>/= 90 y 显示文摘 | Ravaglia G Forti P Maioli F | 2000 | Am J Clin Nutr2000,71,2: | 1 |
| 19 | Determination of Ten Sulphonamides in Egg by Liquid Chromatography - tandem Mass Spectrometry 显示文摘 | Forti A F Scortichini G | 2009 | Anal Chim Acta2009,637,12: | 1 |
| 20 | New conditions for global stability of neural networks with application to linear and quadratic programming problems显示文摘 | Forti M Tesi A | 1995 | IEEE Trans Circuits Systems1995,42,7: | 1 |