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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Kinetic characterisation and thermal inactivation study of polyphenoloxidase and peroxidase from table grape 显示文摘 | FORTEA M I LOPEZ-MIRANDA S SERRANO-MARTNEZ A | 2009 | Food Chemistry2009，113，： | 1 |
| 3 | Effect of time and cerebrovascular symptoms on the prevalence of microembdic signals in patients with cervical carotid stenosis显示文摘 | Fortea A M Babikian VL Hyde C | 1996 | Stroke1996，27，： | 1 |
| 4 | Product formation in the Prato reaction on Sc3N@D5h-C80:Preference for-bonds,and not pyracylenic bonds显示文摘 | Osuna S Rodriguez Fortea A Poblet J M | 2012 | Chemical Communications2012，48，： | 1 |
| 5 | Laser cutting of high-vitrified ceramic materials:development of a method using a Nd∶YAG laser to avoid catastrophic breakdown显示文摘 | COSP J P RAMíREZ DEL VALLE A J FORTEA J G | 2002 | Materials Letters2002，55，4： | 1 |
| 6 | Kinetic characterisation and thermal inactivation study of polyphenol oxidase and peroxidase from table grape显示文摘 | Fortea M I Lopez-Miranda S Serrano-Martnez A | 2009 | Food Chemistry2009，113，： | 1 |
| 7 | Follicular mucinosis secondary to captopril-induced photoallergy显示文摘 | P6rez-Ferriols A Martinez-Mench6n T Fortea JM | 2005 | ActasDermosifiliogr2005，96，3： | 1 |
| 8 | Complexation of resveratrol by native and modified cyclodextrins:Determination of complexation constant by enzymatic,solubility and fluorimetric assays显示文摘 | Lucas-Abellán C Fortea M I Gabaldón J A | | 0，，： | 1 |
| 9 | A general multiplex-PCR assay for the general detection of genetically modified soya!and maize显示文摘 | Fortea V T Di Pinto A Martino C | 2005 | Food Control2005，16，6： | 1 |
| 10 | Lung resection: predictive value of respiratory function显示文摘 | ForteA Lo Storto G Urso A | 2002 | Chit Ital2002，54，1： | 1 |
| 11 | The effect of plant-associative bacteria(Azospirillum and Pantoea) on the fruit quality of sweet pepper under limited nitrogen supply显示文摘 | Delamor FM Serrano-martinez A Fortea MI | 2008 | Scientia Horticulturae2008，117，3： | 1 |
| 12 | Stenosis progression after surgical injury in Milan hypertensive rat carotid arteries 显示文摘 | Fortea A Esposito S De Feoc M | 2003 | Cardiovasc Res2003，60，： | 1 |
| 13 | Complexation of resveratrol by native and modified cyclodextrins : Determination of complexation constant by enzymatic, solubility and fluorimetric assays显示文摘 | Lucas-Abellan C Fortea M I Gabaldon J A | 2008 | Food Chem2008，111，： | 1 |
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