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| 1 | 黏液瘤病毒对胃癌的治疗作用显示文摘目的观察黏液瘤病毒(MYXV)对胃癌细胞的抑制作用。方法选用低分化原发性胃癌细胞(AGS)、来自腹水的转移性胃癌(SNU-1)、来自肝转移的转移性胃癌(NCL—N87)、来自淋巴结转移的转移性胃癌(KATOIII)等4种不同胃癌细胞株,采用Alamarblue分析MYXV对不同胃癌细胞株的抑制作用,采用Westernblot法检测MYXV的病毒复制蛋白(MT-7和Serp-1)在胃癌细胞中的表达,采用NCL.N87细胞株建立裸小鼠人胃癌移植瘤腹腔种植和皮下种植模型,观察MYXV对移植瘤的抑制作用,荧光显微镜下检测荷瘤小鼠体内活病毒。结果MYXV对4种不同胃癌细胞株都有抑制作用,抑制作用的比率分别为31.30%、33.98%、53.09%和50.12%,与对照组NIH3T3比较差异有统计学意义(P〈0.05)。病毒复制蛋白MT-7和Serp-1蛋白在所有4种胃癌细胞中都有表达。MYXV可明显抑制移植瘤的生长,肿瘤抑制率达80%,与对照组比较差异有统计学意义(P〈0.05)。荷瘤小鼠处死后只在瘤内检测到活病毒,而在其他脏器中并未检出活病毒。结论MYXV对人体胃癌具有特异性的杀伤作用而不感染正常组织和细胞,可能是一个潜在的高效安全的肿瘤治疗手段。 | 龚伟 顾均 周迪 赵铭宁 全志伟 方国恩 刘颖斌 Xueqing Lun Peter Forsyth Grant McFacdden 张勇 | 2012 | 中华实验外科杂志2012，29，10： | 2 |
| 2 | The im- pacts of Australia's departure tax: Tourism versus the economy? 显示文摘 | Peter Forsyth Larry dwyer Rayspur Tiampham | 2014 | Tourism Management2014，40，2： | 1 |
| 3 | Foreign Tourism InvestmentMotivation and Impact显示文摘 | Larry Dwyer Peter Forsyth | 1994 | Annals of Tourism Research1994，，3： | 1 |
| 4 | Estimating the Economic Impacts of Tourism Growth and Special Events 显示文摘 | Larry Dwyer Peter Forsyth | 2003 | E - Review of Tourism Research2003，1，1： | 1 |
| 5 | Estimating the Impacts of Special Events on an Economy 显示文摘 | Larry Dwyer Peter Forsyth Ray Spurt | 2005 | Journal of Travel Research2005，，43： | 1 |
| 6 | A Control-volume finite- element method for local mesh refinement in thermal reservoir simulation 显示文摘 | Forsyth Peter A | 1990 | SPE Reservoir Engineering1990，5，4： | 1 |
| 7 | Estimating the Impacts of Special Events on an Economy显示文摘 | Larry Dwyer Peter Forsyth & Ray Spur | 2005 | Journal of Travel Research2005，，43： | 1 |
| 8 | Evaluating Tourism's Economic Effects: New and Old Approaches 显示文摘 | Larry Dwyer Peter Forsyth Ray Spurr | 2004 | Tourism Management2004，25，3： | 1 |
| 9 | Regulation under stress : developments in Australian airport policy 显示文摘 | Forsyth Peter 2003 | 2003 | Journal of Air Transport Management 92003，2535，： | 1 |
| 10 | Assessing the bene- fits and costs of inbound tourism 显示文摘 | Larry Dwyer Peter Forsyth | 1993 | Annals of Tourism Research1993，20，4： | 1 |
| 11 | Regulation under stress:developments in Australian airport policy 显示文摘 | Forsyth Peter 2003 | 2003 | Journal of Air Transport Management2003，，9： | 1 |
| 12 | Economic significance of cruise tourism显示文摘 | Larry Dwyer Peter Forsyth | 1998 | Annals of Tourism Research1998，，2： | 1 |
| 13 | Estimating the impacts of special events on an economy显示文摘 | Larry Dwyer Peter Forsyth Ray Spurr | 2005 | Journal of Travel Research2005，，43： | 1 |
| 14 | Serum Free Light Chains, An Alternative to the Urine Bence Jones Proteins Screening Test for Monoelonal Gammopathies显示文摘 | Peter G Hill Julia M Forsyth Baldeep Rai | 2006 | Clinical Chemistry2006，52，9： | 1 |
| 15 | Assessing the economic impacts of events: a computable general equilibrium approach 显示文摘 | Larry Dwyer Peter Forsyth Ray Spurr | 2006 | Journal of Travel Research2006，45，1： | 1 |
| 16 | Economic Significance of Cruise Tourism 显示文摘 | Larry Dwyer Peter Forsyth | 1998 | Annals of Tourism Research1998，25，2： | 1 |
| 17 | Estimating the Impacts of Special Events on an Economy显示文摘 | Larry Dwyer Peter Forsyth and Ray Spurr | 2005 | Journal of Travel Research2005，43，： | 1 |
| 18 | Estimating the Carbon Foot- print of Australian Tourism 显示文摘 | Dwyer Larry Forsyth Peter Spurr Ray | 2010 | Journal of Sustainable Tourism2010，，3： | 1 |
| 19 | Use of peri-operative anti-epileptic drugs in patients with newly diagnosed high grade malignant glioma: a single center experience显示文摘 | Shelly Lwu Mark G. Hamilton Peter A. Forsyth J. Gregory Cairncross Ian F. Parney | 2010 | Journal of Neuro - Oncology2010，，3： | 1 |
| 20 | The Price Competitiveness of Travel and Tourism : A Comparison of 19 Destinations 显示文摘 | Larry Dwyer Peter Forsyth Rao Prasada | 2000 | Tourism Management2000，21，1： | 1 |
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