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| 1 | Hepatitis B virus infection of transplanted human hepatocytes causes a biochemical and histological hepatitis in immunocompetent rats显示文摘AIM: To characterize the host response to hepatitis B virus (HBV) infection in human hepatocytes transplanted into immunocompetent rodent rats tolerized by, and transplanted with primary human hepatocytes.METHODS: One week after the transplantation, rats were inoculated with HBV, and viral gene expression, replication,and host response was monitored.RESULTS: HBV DNA was detectable in serum for at least 60 days. HBsAg levels rose steadily for 3 weeks postinoculation and then plateaued at a level of about 0.6 pg/mi. HBV RNA was also found in liver at levels that remained constant through the time course. Immunofluorescence revealed clusters of hepatocytes that stained positive for HBcAg. The presence of HBV covalently closed circular DNA (cccDNA) in liver was demonstrated using nuclease digestion of single-stranded DNA followed by PCR. Serum ALT levels rose and reached a peak level of 180 IU/L on day 18, but remained elevated for 60 days. Histology revealed a progressive predominantly mononuclear lobular hepatitis.CONCLUSION: These data indicate that human hepatocytestransplanted into rats rendered tolerant to these cells, when infected by HBV, results in biochemical as well as histological evidence of hepatitis that accompanies viral gene expression,and DNA replication. | Catherine H.Wu Edwin C.Ouyang Cherie Walton Kittichai Promrat Faripour Forouhar George Y. Wu | 2003 | World Journal of Gastroenterology2003，9，5： | 19 |
| 2 | A review of methotrexate‐associated hepatotoxicity显示文摘 | Roopjeet K. Bath Navkiran K. Brar Faripour A. Forouhar George Y. Wu | 2014 | Journal of Digestive Diseases2014，，10： | 2 |
| 3 | Structures of bacteri- al biosynthetic arginine decarboxylases显示文摘 | FOROUHAR F LEW S SEETHARAMAN J | 2010 | Acta Crystallogr F2010，66，12： | 1 |
| 4 | The embryonic vertebrate heart tube is a dynamic suction pump显示文摘 | Forouhar AS Liebling M Hickerson A | 2006 | Science2006，312，5774： | 1 |
| 5 | Eosinophilic digestive diseases : eosinophilic esophagitis, gastroenteritis, and colitis 显示文摘 | Shifflet A Forouhar F Wu G | 2009 | J Formos Med Assoc2009，108，： | 1 |
| 6 | Broad immunocytochemical localization of the formyl peptide receptor in human organs, tissues and cells显示文摘 | Becket EL Forouhar FA Grunnet ML | 1998 | Cell Tissue Res1998，292，： | 1 |
| 7 | Structural basis of membrane-induced cardiotoxin A3 oligomerization显示文摘 | Forouhar F Huang W N Liu J H | 2003 | J Biol Chem2003，278，21： | 1 |
| 8 | Hepatic toxicity of nickel chloride in rata显示文摘 | DONSKOY E DONSKOY M FOROUHAR F | 1986 | Ann Clin Lab Sei1986，16，2： | 1 |
| 9 | Structural basis of membrane-induced cardiotoxin A3 oligomerization 显示文摘 | FOROUHAR F HUANG WN LIU JH | 2003 | Biochem J2003，278，21： | 1 |
| 10 | Transmission electron microscopy: evaluation of damage in human oviduct caused by different surgical instruments 显示文摘 | Olivar AC Forouhar FA Gillies Ms | 1999 | Ann Clin Lab Sci1999，29，4： | 1 |
| 11 | Eosinophilic digestive diseases : Eosinophilic esophagitis, gastroenteritis, and colitis 显示文摘 | Shifflet A Forouhar F Wu GY | 2009 | J Formos Med Assoc2009，108，11： | 1 |
| 12 | Case report and review of esophageal lichen planus treated with fluticasone显示文摘Lichen planus is a fairly common chronic idiopathic disorder of the skin,nails and mucosal surfaces.Esophageal involvement of this disease on the other hand is rare and only about 50 cases have been reported in literature.Given its rarity,it can be difficult to diagnose and may be easily misdiagnosed as reflux esophagitis.Currently,there are no clear recommendations on the optimal management of this disease and little is known about the best treatment approach.Systemic steroids are usually the first line treatment and offer a favorable response.In this report,we would like to present a novel approach in the management of esophageal lichen planus in a middle-aged woman treated successfully with swallowed fluticasone propionate 220 mcg twice a day for 6 wk,as evidenced by objective clinical findings.Based on our review of related literature and experience in this patient,we feel that a trial of swallowed fluticasone may be a prudent approach in the management of these patients since it has a more favorable side effect profile than systemic treatment. | Marie Lourdes Ynson Faripour Forouhar Haleh Vaziri | 2013 | World Journal of Gastroenterology2013，19，10： | 1 |
| 13 | Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis 显示文摘 | Hove JR Koster RW Forouhar AS | 2003 | Nature2003，421，6919： | 1 |
| 14 | Etanercept-Induced Lupus Erythematosus Presenting as a Unilateral Pleural Effusion显示文摘 | Jafar Abunasser Faripour A. Forouhar Mark L. Metersky | 2008 | Chest2008，，4： | 1 |
| 15 | Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity显示文摘 | Forouhar F Yang Y Kumar D | | 0，，： | 1 |
| 16 | Structural basis of membrane-induced zardiotoxin A3oligomerization显示文摘 | FOROUHAR F HUANGW N LIU JH | 2003 | J Biol Chem2003，278，21： | 1 |
| 17 | Eosinophilic digestive diseases: eosinophilic esophagitis, gastroenteritis, and colitis 显示文摘 | Shifflet A Forouhar F Wu GY | 2009 | J Formos Med Assoc2009，108，11： | 1 |
| 18 | Intraeardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis显示文摘 | Koster RW Forouhar AS | 2003 | Nature2003，421，6919： | 1 |
| 19 | Intracardiac flu- id forces are an essential epigenetic factor for embryonic cardiogenesis 显示文摘 | Hove JR Koster RW Forouhar AS | 2003 | Nature2003，421，6919： | 1 |
| 20 | Broad immunocytochemical localization of the formylpeptide receptor in human organs, tissues and cells显示文摘 | Beeker E L Forouhar F A Grunnet M L | 1998 | Cell Tissue Res1998，292，： | 1 |
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