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| 1 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 2 | Expression and clinical significance of Wnt players and survivin in pituitary tumours 显示文摘 | Formosa R Gruppetta M Falzon S | 2012 | Endoer Pathol2012，23，2： | 1 |
| 3 | Reduced UCP-1 content in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity显示文摘 | Carey A L Vorlander C Reddy-Luthmoodoo M Natoli A K Formosa M F Bertovic D A | 2014 | PLoS One2014，9，91： | 1 |
| 4 | Gender differences in large artery stiffness pre- and post puberty显示文摘 | Ahimastos AA Formosa M Dart AM | 2003 | J Clin Endocrinol Metab2003，88，11： | 1 |
| 5 | Thermal Study of Low-grade Magnesium Hydroxide Used as Fire Re- tardant and in Passive Fire Protection显示文摘 | Formosa J Chimenos J M Lacasta A M | 2011 | Therrnochimica Ac- ta2011，515，12： | 1 |
| 6 | Mycoplasma pneumonia-anunusual cause of acute myocarditis in childhood显示文摘 | Formosa GM Bailey M Barbara C | | 0，，04： | 1 |
| 7 | Aggregate material formulated with MSWI bottom ash and APC fly ash for use as secondary building material显示文摘 | De1 Valle-Zermefio R Formosa J Chimenos J M | 2013 | Waste Manage2013，33，3： | 1 |
| 8 | Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjects 显示文摘 | Kingwell B A Formosa M Muhlmann M | 2002 | Diabetes2002，51，8： | 1 |
| 9 | European Union policy on older adult learning:a critical commentary显示文摘 | Formosa M | 2012 | J Aging Soc Policy2012，4，24： | 1 |
| 10 | Aggregate material formulated with MSWl bottom ash and APC fly ash for useas secondary building material 显示文摘 | DEL VALLE-ZERMENO R FORMOSA J CHIMENOS J M | 2013 | Waste Management2013，33，3： | 1 |
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