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| 1 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 2 | miR-143 regulates hexokinase 2 expression in cancer cells显示文摘 | Peschiaroli A Giacobbe A Formosa A | 2013 | Oncogene2013，32，6： | 1 |
| 3 | miR-143 regulates hexokinase 2 expression in cancer cells 显示文摘 | Peschiaroli A Giacobbe A Formosa A | 2013 | Oncogene2013，32，6： | 1 |
| 4 | cAMP signalling in the normal and tu- morigenic pituitary gland显示文摘 | Formosa R Vassallo J | 2014 | Mol Cell Endocrinol2014，392，12： | 1 |
| 5 | Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors 显示文摘 | Camps P Formosa X Munoz-Torrero D | 2005 | J Med Chem2005，48，6： | 1 |
| 6 | Spatial variability of ammonium and nitrate in soils near a poultry farm 显示文摘 | Formosa L Singh B | 2002 | Environmental Pollution2002，120，： | 1 |
| 7 | High-density lipoprotein modu lates glucose metabolism in patients with type 2 diabetes mellitus显示文摘 | Drew BG Duffy SJ Formosa MF | 2009 | Cir- culation2009，119，15： | 1 |
| 8 | miR-143 regulates hexokinase 2 expression in cancer cells显示文摘 | Peschiaroli A Giacobbe A Formosa A | 2013 | Oncogene2013，32，6： | 1 |
| 9 | Novel donepezil- based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation显示文摘 | Camps P Formosa X Galdeano C | 2008 | J Med Chem2008，51，12： | 1 |
| 10 | Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase-and beta-amyloid-directed anti-Alzheimer compounds显示文摘 | Camps P Formosa X Galdeano C | | 0，，： | 1 |
| 11 | Expression and clinical significance of Wnt players and survivin in pituitary tumours 显示文摘 | Formosa R Gruppetta M Falzon S | 2012 | Endoer Pathol2012，23，2： | 1 |
| 12 | The chemical properties of light-and chemical-curing composites with mineral trioxide aggregate filler显示文摘 | Formosa LM Mallia B Camilleri J | 2013 | Dent Mater2013，29，2： | 1 |
| 13 | Corrosion Be- haviour of Carbon S - phase Created on Ni - free Bio- medical Stainless Steel显示文摘 | Dennis Formosa Ralph Hunger | 2012 | Surface & Coatings Tech- nology2012，，： | 1 |
| 14 | DNA methylation silences miR-132 in prostate cancer 显示文摘 | Formosa A Lena AM Markert EK | 2013 | Oneogene2013，32，1： | 1 |
| 15 | Reduced UCP-1 content in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity显示文摘 | Carey A L Vorlander C Reddy-Luthmoodoo M Natoli A K Formosa M F Bertovic D A | 2014 | PLoS One2014，9，91： | 1 |
| 16 | Functional polymorphisms within the TNFRSF11B(osteoprotegerin)gene increase the risk for low bone mineral density显示文摘 | Vidal C Formosa R Xuereb-Anastasi A | 2011 | Journal of Molecular Endocrinology2011，47，3： | 1 |
| 17 | High-density lipoprotein modulates glucose metabolism in patients with type2 diabetes mellitus 显示文摘 | DREW BG DUFFY S J FORMOSA MF | 2009 | Circulation2009，119，： | 1 |
| 18 | Characterization of poly (ethylene-co-vinyl acetate) (EVA) titled with low grade magnesium hydroxide显示文摘 | FERNANDEZ A I HAURIE L FORMOSA J | 2009 | Polym Degrad Stab2009，94，： | 1 |
| 19 | cAMP signalling in the normal and tumorigenic pituitary gland显示文摘 | R. Formosa J. Vassallo | 2014 | 2014 (1-2)2014，，1： | 1 |
| 20 | Coupled thermodynamic - dynamic semi - analytical model of free piston Stiding engines 显示文摘 | Formosa F | 2011 | Energy Con- version and Management2011，，52： | 1 |
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