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| 1 | Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C显示文摘AIM:To investigate the efficacy of Viusid,a nutritional supplement,as an antioxidant and an immunomodulator in patients with chronic hepatitis C.METHODS:Sixty patients with chronic hepatitis C who were non-responders to standard antiviral treatment were randomly assigned to receive Viusid(3 sachets daily,n=30) or placebo(n=30) for 24 wk.The primary outcome was the change in serum malondialdehyde and 4-hydroxyalkenals(lipid peroxidation products).Secondary outcomes were changes in serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ) and interleukin-10(IL-10).RESULTS:Statistically significant reductions in serum 4-hydroxyalkenals and malondialdehyde levels were observed in both groups in comparison with pretreatment values,but the patients who received Viusid showed a more marked reduction as compared with the control group(P=0.001).TNF-α levels significantly increased from 6.9 to 16.2 pg/mL(P< 0.01) in the patients who received placebo in comparison with almost unchanged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the patients treated with Viusid(P=0.001).In addition,IL-10 levels were markedly increased in the patients treated with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contrast to the patients assigned to placebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the administration of Viusid markedly increased mean IFN-γ levels from 1.92 to 2.89 pg/mL(P< 0.001) in comparison with a reduction in mean levels from 1.80 to 1.68 pg/mL(P=0.70) in the placebo group(P< 0.0001).Viusid administration was well tolerated.CONCLUSION:Our results indicate that treatment with Viusid leads to a notable improvement of oxidative stress and immunological parameters in patients with chronic hepatitis C. | Eduardo Vilar Gomez Yadina Martinez Perez Hector Vega Sanchez Gretel Riveron Forment Enrique Arus Soler Luis Calzadilla Bertot Ali Yasells Garcia Maria del Rosario Abreu Vazquez Licet Gonzalez Fabian | 2010 | World Journal of Gastroenterology2010，16，21： | 2 |
| 2 | Chromothripsis and cancer: causes and consequences of chromosome shattering 显示文摘 | Forment J V Kaidi A Jackson S P | 2012 | Nat Rev Cancer2012，12，10： | 1 |
| 3 | Diffusion and resction in a fractal catalyst p ore, I Geometrical aspects显示文摘 | FORMENT G F | 1995 | Chem Eng Sci1995，50，： | 1 |
| 4 | Diffusion and reaction in a fractal catalyst p ore, Ⅱ Diffusion and first-order reaction显示文摘 | FORMENT G F | 1995 | Chem Eng Sci1995，50，： | 1 |
| 5 | Thermal cracking of isobutane显示文摘 | Alfons G Buekens Gilbert F Forment | 1971 | In Eng Chem Process Des Develop1971，10，3： | 1 |
| 6 | Hereditary breast cancer:clinical features and risk reduction strategies显示文摘 | Paradiso A Forment S | 2011 | Ann Oncol2011，22，： | 1 |
| 7 | Nickel electrocrystallization from nucleation to textures显示文摘 | Amblard J Forment M Maurin G | 1983 | Electrochem Acta1983，28，7： | 1 |
| 8 | Gene expression analysis in citrus reveals the role of gibberellins on photosynthesis and stress显示文摘 | HUERTA L FORMENT J GADEA J | 2008 | Plant Cell Environ2008，31，11： | 1 |
| 9 | Consecutive gene deletions in Aspergillus nidulans:application of the Cre/loxP system显示文摘 | FORMENT J V RAMON D MACCABE A P | 2006 | Curr Genet2006，50，3： | 1 |
| 10 | Development of ChillPeach genomic tools and identification of cold-responsive genes in peach fruit显示文摘 | OGUNDIWIN E A MARTI C FORMENT J PONS C GRANELL A GRADZIEL T M PEACE C P CRISOSTO C H | 2008 | Plant Molecular Biology2008，68，45： | 1 |
| 11 | Catalytic conversion of methanol into light alkenes on mordenite-like zeolites 显示文摘 | Marchi A J Forment G F | 1993 | Appl Catal A:General1993，94，1： | 1 |
| 12 | Transcriptomic pro-filing of citrus fruit peel tissues reveals fundamental effects of phenylpropanoids and ethylene on induced resistance显示文摘 | Ballester AR Lafuente MT Forment J | | 0，，09： | 1 |
| 13 | Investigations on the effect of additives during C102 prebleaching显示文摘 | Joncourt M J Forment P Lachenal D | 1997 | Preprints International Symposia Wood Pulping Chem PAPTAC1997，1997，： | 1 |
| 14 | Fallopian tube disease on magnetic resonance imaging 显示文摘 | La Parra Casado C Molina Fttbrega R Forment Navarro M | 2013 | Ra- diologra ( English Edition)2013，55，： | 1 |
| 15 | Expression of Arabidopsis SR like splicing proteins confers salt tolerance to yeast and transgenic plants显示文摘 | Forment J Naranjo M A Roldan M | 2002 | Plant J2002，30，5： | 1 |
| 16 | Application of a single-event kinetic model in the simulation of an industrial riser reactor for the catalytic cracking of vacuum gas oil显示文摘 | Dewachtere N V Santaella F Forment G F | 1999 | Chem Eng Sci1999，54，1516： | 1 |
| 17 | Fal- lopin tube diseases on magnetic resonance imaging 显示文摘 | La Parra Casado Molina FNarega R Forment Navarro M | 2013 | Radiologia2013，55，9： | 1 |
| 18 | Site and mechanism of enhanced gastrointenal absorption of aluminium by eitrate显示文摘 | Forment DP | 1989 | Kid Int1989，36，： | 1 |
| 19 | Development of a Citrus genome-wide EST collection and cDNA microarray as resources for genomic studies显示文摘 | Forment J Gadea J Huerta L | 2005 | Plant Mol Biol2005，57，3： | 1 |
| 20 | Overexpression of Arabidopsis thaliana LTL1,a salt-induced gene encoding a GDSL-motif lipase,increases salt tolerance in yeast and transgenic plants显示文摘 | Naranjo M A Forment J Roldán M | 2006 | Plant Cell Environ2006，29，10： | 1 |
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