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| 1 | Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure显示文摘BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical settings.AIM To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of CRS-1.METHODS We performed a retrospective cohort,multi-centre study.From January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary syndrome.We monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU admission.RESULTS Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required dialysis.Neither the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak value.Finally,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly correlated.CONCLUSION In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart disease.So,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage. | Fiorenza Ferrari Elisa Scalzotto Pasquale Esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte Matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco | 2020 | World Journal of Clinical Cases2020，8，9： | 3 |
| 2 | Nerve-sparing radical hysterectomy: a surgical technique for preserving the autonomic hypogastric nerve显示文摘 | Francesco Raspagliesi Antonino Ditto Rosanna Fontanelli Eugenio Solima Francesco Hanozet Flavia Zanaboni Shigeki Kusamura | 2004 | Gynecologic Oncology2004，，2： | 2 |
| 3 | Effects of epidural and system- ie maternal analgesia in term infants: the NoPiL study 显示文摘 | Dani C Perugi S Fontanelli G | 2010 | Front Biosci (Elite Ed)2010，2，： | 1 |
| 4 | Surgical staging for epithelial ovarian tumors of low malignant potential显示文摘 | Di Re F Paladini D Fontanelli R | 1994 | Int J Gynecol Cancer1994，4，5： | 1 |
| 5 | Systematic pelvie and paraaortie lymphadeneetomy for advanced ovarian eaneer: prognostic significance of node metastases 显示文摘 | di Re F Baioeehi G Fontanelli R | 1996 | Gyneeol Oncol1996，62，3： | 1 |
| 6 | Nerve-sparing radical hysterectomy:a surgical technique for preserving the autonomic hypogastric nerve 显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2004 | Gynecol Oncol2004，93，2： | 1 |
| 7 | Conservative surgery in high-risk epithelial ovarian carcinoma显示文摘 | Raspagliesi F Fontanelli R Paladini D | 1997 | J Am Coll Surg1997，185，5： | 1 |
| 8 | Nerve - sparing radical hysterectomy: a surgical technique for preserving the autonomic hypogas- tric nerve 显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2004 | Gynecol Oncol2004，93，5： | 1 |
| 9 | Type versus Type Ⅱ nerve - sparing radical hysterectomy: comparison of lower urinary tract dysfunctions 显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2006 | Gynecol Oncol2006，102，2： | 1 |
| 10 | Type Ⅱ versus Type Ⅲ nerve-sparing radical hysterectomy: comparison of lower urinary tract dysfunctions 显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2006 | Gynecol Oncol2006，102，2： | 1 |
| 11 | Mechanical properties of jute fibers and interface strength with an epoxy resin显示文摘 | TRIPATHY S S LANDRO L D FONTANELLI D | 2000 | Journal of Applied Polymer Science2000，75，13： | 1 |
| 12 | Type Ⅱ versus Type Ⅲ nerve-sparing radical hysterectomy:comparison of lower urinary tract dysfunctions显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2006 | Gynecol Oncol2006，102，2： | 1 |
| 13 | Nerve sparing radical hysterectomy: a surgical technique for p reserving theautonomic hypogastfic nerve 显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2004 | Gynecol Oncol2004，93，2： | 1 |
| 14 | Perfluoropolyethers:their physical properties and behavior at high and low temperature显示文摘 | Sianesi D Zamboni V Fontanelli R | | 0，，： | 1 |
| 15 | Nerve-sparing radical hysterectomy: a surgical technique for preserving the autonomic hypogastric nerve 显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2004 | Gynecol Oncol2004，93，： | 1 |
| 16 | Nerve-sparing radical hysterectomy: a surgical technique for preserving the autonomic hypogastric nerve 显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2004 | Gynecol Oncol2004，93，2： | 1 |
| 17 | Sorafenib as monotherapy or in association with cytarabine and clofarabine for the treatment of relapsed / refractory FLT3 ITD-positive advanced acute myeloid leukemia 显示文摘 | Fontanelli G Rocco M Caraccciolo F | 2014 | Clin Lymphoma Myeloma Leuk2014，14，1： | 1 |
| 18 | Conservative surgery in high-risk epithelial ovarian carcinoma显示文摘 | Raspagliesi F Fontanelli R Paladini D | 1997 | J Am Coll Surg1997，185，： | 1 |
| 19 | Ovarian cancer management, Practice guidelines for nuclear physicians 显示文摘 | Classe J M Fontanelli R Bischof-Delaloye A | 2004 | Nucl Med Mol Imaging2004，48，2： | 1 |
| 20 | Nerve-sparing radi- cal hysterectomy: a surgical technique for preserving the auto- nomic hypogastric nerve显示文摘 | Raspagliesi F Ditto A Fontanelli R | 2004 | Gynecol Oncol2004，93，： | 1 |
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