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| 1 | Effect of vildagliptin as add-on therapy to a low-dose metformin显示文摘AIM:To evaluate the efficacy and safety of the addition of vildagliptin to low-dose metformin and compare it to an uptitration of metformin in type 2 diabetes mellitus(T2DM) patients who have inadequate control with metformin monotherapy.METHODS:Eligible patients were randomized to receive vildagliptin 100 mg qd or metformin(500 mg qd for 2 wk and then 500 mg bid) added to open label me tformin 500 mg bid for the 24 wk.The primary endpoi nt was baseline to endpoint hemoglobin A1c(HbA1c) change.RESULTS:The adjusted mean change from baseline in HbA1c at the 24th wk was-0.51% in the vildagliptin/metformin group(mean baseline HbA1c:7.4%) and-0.37% in the metformin monothera py group(mean baseline HbA1c:7.3%).The mean diffe rence was-0.14% with 95% Confidence Interval(-0.24%,-0.05%).As non-inf e riority(margin of 0.4%) was achieved,a test for superiority was performed.This test showed statistically significant superiority of the combination over monotherapy group(P = 0.002).Gastrointestinal(GI) adverse events were signif icantly more frequent in the metformin group than the combin ation group(21.0% vs 15.4%,P = 0.032).CONCLUSION:In patients with T2DM inadequately controlled with metformin up to 1000 mg daily,the addition of vildagliptin 100 mg daily achieved larger HbA1c reduction with fewer GI events than with increa sing the metformin dose. | Claudia Filozof Sherwyn Schwartz James E Foley | 2010 | World Journal of Diabetes2010，1，1： | 8 |
| 2 | Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year 显示文摘 | Ahr6n B Pacini G Foley J E | 2005 | Diabetes Care2005，28，8： | 1 |
| 3 | Release of lysozyme from hemolymph cell of Mercenaria mercenaria duphagocytosis 显示文摘 | Cheng T C Rodick G E Foley D A | 1975 | J Invertebrate Pathology1975，25，： | 1 |
| 4 | Knowing when to grow:signals regulating bud dormancy显示文摘 | HORVATH D P ANDERSON J V CHAO W S FOLEY M E | 2003 | Trends in Plant Science2003，8，： | 1 |
| 5 | Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones,islet function,and postprandial glycemia in subjects with impaired glucose tolerance显示文摘 | Rosenstock J Foley J E Rendell M | 2008 | Diabetes Care2008，31，1： | 1 |
| 6 | The parameter R2 in multiquadric interpolation显示文摘 | Carlson R E Foley T A | 2001 | Computers and Mathematics with Application2001，21，9： | 1 |
| 7 | Enlarged subcutaneous abdominal adipocyer size, but not obesity itself, predicts type Ⅱ independent of insulin resistance 显示文摘 | Weyer C Foley J E Bogardus C | 2000 | Diabetologia2000，43，： | 1 |
| 8 | Assessing the general safety and tolerability of vildagliptin:value of pooled analyses from a large safety database versus evaluation of individual studies显示文摘 | Schweizer A Dejager S Foley J E | 2011 | Vasc Health Risk Manag2011，7，： | 1 |
| 9 | Mindfulness--based cognitive thera- py for individuals whose lives have been affected by cancer a randomized controlled trial显示文摘 | Foley E Baillie A Huxter M | 2010 | J Consult Clin Psyehol2010，78，1： | 1 |
| 10 | Rapid,flow cytometric assay for NK alloreactivity reveals exceptions to rules governing alloreactivity显示文摘 | De Santis D Foley BA John E | 2010 | Biol Blood Marrow Transplant2010，16，2： | 1 |
| 11 | Release of lysozyme from hemolymph cell of Mercenaria mercenaria during phagocytosis显示文摘 | CHENG T C RODICK G E FOLEY D A | 1975 | Invertebr Pathol1975，25，： | 1 |
| 12 | Phenomenon of spectral switches as a new effect in singular optics with polychromatie light 显示文摘 | Foley J T Wolf E | 2002 | J Opt Soc Am A2002，19，12： | 1 |
| 13 | Vegetation and soil feedbacks on the response of the African monsoon to orbital forcing in the Early to Middle Holocene显示文摘 | BONAN G FOLEY J | 1996 | Nature1996，384，： | 1 |
| 14 | Detection of arsenic in groundwater using a surface plasmon resonance sensor显示文摘 | FORZANI E S FOLEY K WESTERHOFFL P | | 0，，： | 1 |
| 15 | Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy 显示文摘 | Ahr6n B Foley J E Ferrannini E el al | 2010 | Diabetes Care2010，33，4： | 1 |
| 16 | Recurrence of fetal macrosomia in non-diabetic pregnancies显示文摘 | Walsh C A Mahony R T Foley M E | 2012 | J Obstet Gynecol2012，27，4： | 1 |
| 17 | Effect of sampling rate on resolution in comprehensive two-dimensional liquid chro matography显示文摘 | Murphy R E Schure M R Foley J P | 1998 | Anal Chem1998，70，8： | 1 |
| 18 | Inhibition of oxide formation on aluminum nanoparticles by transition metal coating显示文摘 | Foley T J Johnson C E Higa K T | 2005 | Chem Maters2005，17，16： | 1 |
| 19 | Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-na? ve patients with type 2 diabetes显示文摘 | Foley J E Sreenan S | 2009 | Horm Metab Res2009，41，12： | 1 |
| 20 | Rapid,flow cytometric assay for NK alloreactivity reveals exception to rules goveming a12 loreactivity显示文摘 | De Santis D Foley BA John E | 2010 | Biol Blood Marrow transplant2010，16，2： | 1 |
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