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| 1 | Challenging aspects of treatment strategies in heart failure with preserved ejection fraction: “Why did recent clinical trials fail?”显示文摘Heart failure(HF) is the leading cause of hospitalization among older adults and the prevalence is growing with the aging populations in the Western countries. Epidemiologic reports suggest that approximately 50% of patients who have signs or symptoms of HF have preserved left ventricular ejection fraction. This HF type predominantly affects women and the elderly with other co-morbidities, such as diabetes, hypertension, and overt volume status. Most of the current treatment strategies are based on morbidity benefits such as quality of life and reduction of clinical HF symptoms. Treatment of patients with HF with preserved ejection fraction displayed disappointing results from several large randomized controlled trials. The heterogeneity of HF with preserved ejection fraction, understood as complex syndrome, seems to be one of the primary reasons. Here, we present an overview of the current management strategies with available evidence and new therapeutic approach from drugs currently in clinical trials, which target diastolic dysfunction, chronotropic incompetence, and risk factor management. We provide an outline and interpretation of recent clinical trials that failed to improve outcome and survival in patients with HF with preserved ejection fraction. | Peter Moritz Becher Nina Fluschnik Stefan Blankenberg Dirk Westermann | 2015 | World Journal of Cardiology2015，7，9： | 3 |
| 2 | Inhibition ofelevated Ca2+/calmodulin dependent protein kinase Ⅱ improvescontractility in human failing myocardium显示文摘 | SOSSALLA S FLUSCHNIK N SCHOTOLA H | 2010 | Circ Res2010，107，9： | 1 |
| 3 | City density and C02 efficiency显示文摘 | GUDIPUDI R FLUSCHNIK T R0S A G C | 2016 | Energy Policy2016，91，： | 1 |
| 4 | Ca MKⅡ-dependent diastolic SR Ca2+leak and elevated diastolic Ca2+levels in right atrial myocardium of patients with atrial fibrillation显示文摘 | Neef S Dybkova N Sossalla S Ort KR Fluschnik N Neumann K | 2010 | Circ Res2010，106，6： | 1 |
| 5 | Inhibition of elevated Ca2 +/ealmedu- lin-dependent protein kinase II improves contractility in human failing myoear- dium显示文摘 | Sossalla S Fluschnik N Schotola H | 2010 | Circ Res2010，107，9： | 1 |
| 6 | Inhi- bition o{ elevated Ca2+/calmodulin-dependent protein kinase l improves contractility in human {ailing myocardium显示文摘 | SOSSALLA S FLUSCHNIK N SCHOTOLA H | 2010 | Circ Res2010，107，9： | 1 |
| 7 | Diagnosing heart failure with preserved ejection fraction显示文摘 | Peter Moritz Becher Diana Lindner Nina Fluschnik Stefan Blankenberg Dirk Westermann | 2013 | Expert Opinion on Medical Diagnostics2013，，5： | 1 |
| 8 | Fulminant isolated cardiac sarcoidosis with pericardial effusion and acute heart failure: Challenging aspects of diagnosis and treatment显示文摘This case report illustrates challenging aspects of diagnosis and treatment of isolated sarcoid heart disease(SHD) and the role of cardiovascular magnetic resonance(CMR) imaging. Here, we present a previously healthy 45-year-old man, who was admitted with pericardial effusion and symptoms of acute heart failure. CMR followed by targeted left ventricular endomyocardial biopsy(EMB) revealed the diagnosis of isolated SHD. The combined use of CMR and EMB was crucial in diagnosing SHD. Furthermore, this case report demonstrates the value of CMR for monitoring response to therapy and lesion healing. | Nina Fluschnik Gunnar Lund Peter Moritz Becher Stefan Blankenberg Kai Muellerleile | 2016 | World Journal of Clinical Cases2016，4，3： | 0 |
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