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| 1 | Effect of dietary fat content on the inci- dence of obesity among ad libitum fed mice 显示文摘 | Salmon D M J P Flatt | 1985 | Int J Obes1985，9，6： | 1 |
| 2 | Compa-rison between ADCP and transmissometer measurements of suspended sedment concentration显示文摘 | HOLDAWAY G P THORNE P D FLATT D | | 0，，19： | 1 |
| 3 | Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes 显示文摘 | Green B D Flatt P R Bailey C J | 2006 | Diabetes Vasc Dis Res2006，3，3： | 1 |
| 4 | Dipeptidyl peptidase IV (DPP IV) inhibitors:a newly emerging drug class for the treatment of type 2 diabetes显示文摘 | GREEN B D FLATT P R BAILEY C J | 2006 | Diab Vasc Dis Res2006，3，3： | 1 |
| 5 | Comparison between ADCP and transmissometer measurements of suspended sedi ment concentration显示文摘 | HOLDAWAY G P THOME P D FLATT D | 1999 | Continental Shelf Research1999，19，3： | 1 |
| 6 | Comparison between ADCP and transmissometer measurements of suspended sediment concentration显示文摘 | HOLDAWAY G P THORNE P D FLATT D | 1999 | Continental Shelf Research1999，19，： | 1 |
| 7 | Dipeptidyl peptidase Ⅳ(DPPⅣ)and related molecules in type 2 diabetes显示文摘 | Flatt P R Bailey C J Green B D | 2008 | Front Biosci2008，13，5： | 1 |
| 8 | Dipeptidy-peptidase Ⅳ (DPP Ⅳ) and related molecules in type 2 diabetes显示文摘 | Flatt P R Bailey C J Green B D | 2008 | Front Biosci2008，13，5： | 1 |
| 9 | Comparison between ADCP and transmissometer measurements of suspended sediment concentration显示文摘 | HOLDAWAY G P THORNE P D FLATT D | 1999 | Continental Shelf Res1999，19，： | 1 |
| 10 | Comparison between ADCP and transmissometer measurements of suspended sediment coneentration显示文摘 | Glenn P H Thorne P D Flatt D | 1999 | Continental Shelf Research1999，19，： | 1 |
| 11 | Comparison between ADCP and transmissometer measurements of suspended sediment concentration显示文摘 | Glenn P H Thome P D Flatt D | 1999 | Continental Shelf Research1999，19，： | 1 |
| 12 | Comparison between ADCP and transmissometer measurements of suspended sediment concentration显示文摘 | Holdaway G P Thorne P D Flatt D | 1999 | Continental Shelf Research1999，19，： | 1 |
| 13 | Reduced selenium in asthmatic subjects in New Zealand显示文摘 | FLATT A PEARCE N THOMSON C D | 1990 | Thorax1990，45，： | 1 |
| 14 | Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes显示文摘 | BAILEY C J GREEN B D | 2008 | Front Biosci2008，3，： | 1 |
| 15 | Life history evolution显示文摘 | Fabian D Flatt T | 2012 | Nat Educ Knowl2012，3，10： | 1 |
| 16 | Dipeptidyl peptidase IV(DPP IV)inhibitors:A newly emerging drug class for the treatment of type 2 diabetes显示文摘 | Green B D Flatt P R Bailey C J | 2006 | Diab Vasc Dis Res2006，3，3： | 1 |
| 17 | Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice显示文摘AIM To investigate the potential of implanting pseudoislets formed from human insulin-releasing β-cell lines as an alternative to islet transplantation. METHODS In this study, the anti-diabetic potential of novel human insulin releasing 1.1B4 β-cells was evaluated by implanting the cells, either as free cell suspensions, or as three-dimensional pseudoislets, into the subscapular region of severe combined immune deficient mice rendered diabetic by single high-dose administration of streptozotocin. Metabolic parameters including food and fluid intake, bodyweight and blood glucose were monitored throughout the study. At the end of the study animals were given an intraperitoneal glucosetolerance test. Animals were then culled and blood and tissues were collected for analysis. Insulin and glucagon contents of plasma and tissues were measured by insulin radioimmunoassay and chemiluminescent enzyme-linked immunosorbance assay respectively. Histological analyses of pancreatic islets were carried out by quantitative fluorescence immunohistochemistry staining. RESULTS Both pseudoislet and cell suspension implants yielded well vascularised β-cell masses of similar insulin content. This was associated with progressive amelioration of hyperphagia(P < 0.05), polydipsia(P < 0.05), body weight loss(P < 0.05), hypoinsulinaemia(P < 0.05), hyperglycaemia(P < 0.05- P < 0.001) and glucose tolerance(P < 0.01). Islet morphology was also significantly improved in both groups of transplanted mice, with increased β-cell(P < 0.05- P < 0.001) and decreased alpha cell(P < 0.05- P < 0.001) areas. Whereas mice receiving 1.1B4 cell suspensions eventually exhibited hypoglycaemic complications, pseudoislet recipients displayed a more gradual amelioration of diabetes, and achieved stable blood glucose control similar to non-diabetic mice at the end of the study. CONCLUSION Although further work is needed to address safety issues, these results provide proof of concept for possible therapeutic applicability of human β-cell line pseudoislets in diabetes. | Alastair D Green Srividya Vasu Neville H McClenaghan Peter R Flatt | 2016 | World Journal of Diabetes2016，7，19： | 1 |
| 18 | Comparison between ADCP and transmissometer measurements of suspended sediment concentration显示文摘 | Glenn P Holdaway Peter D Thome David Flatt | 1999 | Continental Shelf Research1999，19，3： | 1 |
| 19 | Comparison between ADCP and transmissometer measurements of suspended sediment concentration 显示文摘 | HOLDAWAY G P THORNE P D FLATT D | 1999 | Continental Shelf Research1999，19，： | 1 |
| 20 | Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and-IB and brevinins-lE and-2EC with novel insulin re/easing activity显示文摘 | Marenah L Flatt P R Orr D F | 2006 | JEndocrino2006，188，1： | 1 |
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