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| 1 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 2 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 3 | Comparison and evaluation of retrospective intermodality brain image registration techniques显示文摘 | West J Fitzpatrick JM Wang MY | 1997 | Journal of Computer Assisted Tomography1997，21，4： | 2 |
| 4 | A computational grammar of discourse-neutral prosodic phrasing in English显示文摘 | Bachenko J Fitzpatrick E | 1990 | Computational Linguistics1990，16，3： | 2 |
| 5 | Questionnaire on the perceptions of patients about shoulder surgery显示文摘 | Fitzpatrick R Carr A | 1996 | J Bone Joint Surg(Br)1996，78，： | 1 |
| 6 | Caffeic acid phenethyl ester,an inhibitor of nuclear factor-kappaB,attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats显示文摘 | Wang J Le T | 2001 | J-Pharmacol-Exp-Ther2001，299，3： | 1 |
| 7 | 7c Gold urinary assay of neural thread protein in Alzheimer' s disease显示文摘 | Munzar M Fochi M | 2000 | Alz Reports2000，3，3： | 1 |
| 8 | On minimalist approaches to the locality of movement 显示文摘 | Fitzpatrick J | 2002 | Linguistic Inquiry2002，，33： | 1 |
| 9 | The assessment of shoulder instability:the development and validation of a questionnaire显示文摘 | Fitzpatrick R Carr A | 1999 | J Bone Joint Surg(Br)1999，81，： | 1 |
| 10 | Sludge processing by anaerobic digestion and superheated steam drying显示文摘 | | 1998 | Water Research1998，32，10： | 1 |
| 11 | Green chemistry: science and politics of change 显示文摘 | Poliakoff M Fitzpatrick J M Farren T R Anastas P T | 2002 | Science2002，297，： | 1 |
| 12 | The London Millennium Footbridge 显示文摘 | Dallard P Fitzpatrick A J Flint A | 2001 | TheStructural Engineer2001，79，22： | 1 |
| 13 | Detailed study of attached and separated compression corner flowfields in high Reynolds number supersonic flow 显示文摘 | Settles G S Fitzpatrick T J Bogdonoff S M | 1979 | A IAA Journal1979，17，6： | 1 |
| 14 | MHC class Ⅱ expression in the bovine mammary gland显示文摘 | Fitzpatrick J L P J Cripps A W Hill | 1992 | Veterinary Immunology Immunopathology1992，32，： | 1 |
| 15 | Candidate genes for behavioural ecology显示文摘 | FITZPATRICK M J BEN-SHAHAR Y SMID H M | 2005 | Trends Ecol Evol2005，20，2： | 1 |
| 16 | Genetic algorithms in noisy environments显示文摘 | Fitzpatrick J M Grenfenstette J J | 1988 | Machine Learning:Speical Issue on Genetic Algorithms1988，，3： | 1 |
| 17 | Registration of head volume images using implantable fiducial markers显示文摘 | Maurer C R Jr Fitzpatrick J M Wang M Y | 1997 | IEEE Transactions on Medical Imaging1997，16，4： | 1 |
| 18 | Comparison and evaluation of retrospective intermodality brain image registration techniques 显示文摘 | West J Fitzpatrick J M Wang M Y | 1997 | Journal of Computer Assisted Tomography1997，，4： | 1 |
| 19 | Clinical and Subclinical Mastitis in Smallholder Dairy Farms in Tanzania: Risk, Intervention and Knowledge Transfer显示文摘 | Karimuribo E D J L Fitzpatrick D M Kambarage | 2006 | Preventive Veterinary Medicine2006，74，1： | 1 |
| 20 | Model ing water release and absorption in soils using cel ular automata显示文摘 | Aitkenhead M J Foster A R FitzPatrick E A | | 0，，220： | 1 |
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